AutismKB 2.0

Annotation Detail for PDGFB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDGFB ( FLJ12858,PDGF2,SIS,SSV,c-sis )
Gene Full Name: platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Band: 22q13.1
Quick LinksEntrez ID:5155; OMIM: 190040; Uniprot ID:PDGFB_HUMAN; ENSEMBL ID: ENSG00000100311; HGNC ID: 8800
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor8 / 13630258
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal60 / 336030717
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain14 / 110098912
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye0 / 2110540 
heart5 / 8962655
intestine9 / 23447238
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth7 / 67052104
muscle0 / 1077150 
nerve0 / 157680 
ovary4 / 10205139
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta17 / 28082560
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216061_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.55
Adipocyte23.8
AdrenalCortex48.2
Adrenalgland29.8
Amygdala23.45
Appendix48.15
AtrioventricularNode27.45
BDCA4+_DentriticCells19.2
Bonemarrow26.6
BronchialEpithelialCells24.75
CD105+_Endothelial23.95
CD14+_Monocytes22.3
CD19+_BCells(neg._sel.)20.65
CD33+_Myeloid23.2
CD34+20.4
CD4+_Tcells31.75
CD56+_NKCells22.75
CD71+_EarlyErythroid37.65
CD8+_Tcells28.5
CardiacMyocytes33.4
Caudatenucleus24.35
Cerebellum31.05
CerebellumPeduncles44.9
CiliaryGanglion36
CingulateCortex27.7
Colorectaladenocarcinoma53.35
DorsalRootGanglion43.05
FetalThyroid29.2
Fetalbrain27.8
Fetalliver21
Fetallung27.5
GlobusPallidus19.95
Heart33.35
Hypothalamus27.8
Kidney24
Leukemia_chronicMyelogenousK-56224.65
Leukemia_promyelocytic-HL-6023.85
Leukemialymphoblastic(MOLT-4)24.3
Liver30.9
Lung27.15
Lymphnode25.75
Lymphoma_burkitts(Daudi)35.4
Lymphoma_burkitts(Raji)31.8
MedullaOblongata27.5
OccipitalLobe24.45
OlfactoryBulb54.05
Ovary20.5
Pancreas29.35
PancreaticIslet30.6
ParietalLobe30.65
Pituitary28.55
Placenta36.55
Pons28.3
PrefrontalCortex34.35
Prostate27.3
Salivarygland27
SkeletalMuscle56.25
Skin60
SmoothMuscle24.05
Spinalcord27.8
SubthalamicNucleus29.85
SuperiorCervicalGanglion76.65
TemporalLobe41.55
Testis23.4
TestisGermCell20.2
TestisIntersitial22.6
TestisLeydigCell26.75
TestisSeminiferousTubule77.65
Thalamus30.1
Thymus20.6
Thyroid30.3
Tongue26.5
Tonsil28
Trachea29.9
TrigeminalGanglion79.2
Uterus23.05
UterusCorpus33.85
WholeBlood29.45
Wholebrain13.6
colon26.5
pineal_day36.14
pineal_night32.34
retina35.575
small_intestine22.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14345_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.41 ± 0.51
Basal Forebrain4.27 ± 0.42
Basal Part of Pons3.98 ± 0.6
Cerebellar Cortex3.91 ± 0.42
Cerebellar Nuclei4.21 ± 0.5
Claustrum4.76 ± 0.81
Epithalamus3.6 ± 0.35
Frontal Lobe4.16 ± 0.52
Globus Pallidus4.81 ± 0.41
Hypothalamus3.91 ± 0.69
Insula4.45 ± 0.55
Limbic Lobe4.5 ± 0.57
Mesencephalon4.28 ± 0.58
Myelencephalon4.36 ± 0.61
Occipital Lobe4.17 ± 0.5
Parietal Lobe4.22 ± 0.64
Pontine Tegmentum4.27 ± 0.52
Striatum4.66 ± 0.5
Subthalamus4.14 ± 0.19
Temporal Lobe4.33 ± 0.48
Thalamus4.39 ± 0.53
White Matter4.14 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PdgfbCBCerebellum9.76
11.74
PdgfbCTXCerebral cortex18.29
12.94
PdgfbHIPHippocampal region15.49
16.2
PdgfbHPFHippocampal formation15.92
15.42
PdgfbHYHypothalamus4.11
3.34
PdgfbLSXLateral septal complex5.02
3.9
PdgfbMBMidbrain3.37
3.51
PdgfbMYMedulla7.63
9.16
PdgfbOLFOlfactory bulb23.99
18.32
PdgfbPPons6.2
6.58
PdgfbPALPallidum4.34
3.78
PdgfbRHPRetrohippocampal region16.45
14.24
PdgfbsAMYStriatum-like amygdalar nuclei5.6
4.59
PdgfbSTRStriatum3.7
3.03
PdgfbSTRdStriatum dorsal region2.6
2.27
PdgfbSTRvStriatum ventral region5.42
3.82
PdgfbTHThalamus4.54
3.82
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00137837 12 67 78 SHSGGELESLAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved