AutismKB 2.0

Annotation Detail for IL23A


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Basic Information Top
Gene Symbol:IL23A ( IL-23,IL-23A,IL23P19,MGC79388,P19,SGRF )
Gene Full Name: interleukin 23, alpha subunit p19
Band: 12q13.3
Quick LinksEntrez ID:51561; OMIM: 605580; Uniprot ID:IL23A_HUMAN; ENSEMBL ID: ENSG00000110944; HGNC ID: 15488
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult25 / 193912112
embryoid body8 / 70761113
blastocyst1 / 6231916
fetus16 / 56401228
neonate2 / 3109764
infant0 / 236200 
juvenile21 / 55556377
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal26 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia31 / 95842323
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma25 / 71755348
non-neoplasia3 / 9725030
normal146 / 336030743
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung12 / 33697435
lymph0 / 442700 
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood44 / 123478356
bone3 / 7165541
bone marrow1 / 4880120
brain6 / 11009895
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye0 / 2110540 
heart8 / 8962689
intestine9 / 23447238
kidney7 / 21177733
larynx1 / 2414541
liver3 / 20774314
lung19 / 33697456
lymph13 / 44270293
lymph node9 / 9161098
mammary gland2 / 15327113
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx7 / 41328169
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen8 / 53952148
stomach4 / 9661941
testis0 / 3304420 
thymus125 / 811311540
thyroid4 / 4747384
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220054_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.65
Adipocyte6.15
AdrenalCortex7.3
Adrenalgland5.4
Amygdala6.25
Appendix9.8
AtrioventricularNode8.1
BDCA4+_DentriticCells6.25
Bonemarrow6.6
BronchialEpithelialCells6.1
CD105+_Endothelial5.95
CD14+_Monocytes6.45
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid7.55
CD34+7.6
CD4+_Tcells7.05
CD56+_NKCells6.8
CD71+_EarlyErythroid5.7
CD8+_Tcells6.2
CardiacMyocytes7.85
Caudatenucleus5.65
Cerebellum5.15
CerebellumPeduncles7.35
CiliaryGanglion6.15
CingulateCortex8
Colorectaladenocarcinoma6.3
DorsalRootGanglion5.95
FetalThyroid6.15
Fetalbrain6.25
Fetalliver5.5
Fetallung4.85
GlobusPallidus4.85
Heart9.35
Hypothalamus6.55
Kidney5.6
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)4.95
Liver8.7
Lung6.55
Lymphnode5.3
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)8.65
MedullaOblongata5.85
OccipitalLobe5.6
OlfactoryBulb5
Ovary4.8
Pancreas5.2
PancreaticIslet6.75
ParietalLobe6.95
Pituitary7.45
Placenta6
Pons11.35
PrefrontalCortex7.4
Prostate7
Salivarygland5.15
SkeletalMuscle11.8
Skin5.95
SmoothMuscle6.95
Spinalcord6.8
SubthalamicNucleus5.8
SuperiorCervicalGanglion9.6
TemporalLobe5.85
Testis7.7
TestisGermCell5.45
TestisIntersitial9.3
TestisLeydigCell7.6
TestisSeminiferousTubule11.9
Thalamus6.45
Thymus4.6
Thyroid7.3
Tongue6.6
Tonsil6.3
Trachea5.15
TrigeminalGanglion7.2
Uterus4.85
UterusCorpus6.05
WholeBlood6.85
Wholebrain5.2
colon6.15
pineal_day7.5
pineal_night7.34
retina7.425
small_intestine5.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13132_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.96 ± 0.99
Basal Forebrain1.39 ± 0.18
Basal Part of Pons1.26 ± 0.48
Cerebellar Cortex1.42 ± 0.73
Cerebellar Nuclei1.91 ± 0.8
Claustrum2.24 ± 0.73
Epithalamus1.22 ± 0.66
Frontal Lobe1.41 ± 0.65
Globus Pallidus1.97 ± 0.41
Hypothalamus1.53 ± 0.65
Insula1.32 ± 0.46
Limbic Lobe1.5 ± 0.68
Mesencephalon1.65 ± 0.71
Myelencephalon1.53 ± 0.67
Occipital Lobe1.45 ± 0.69
Parietal Lobe1.57 ± 0.7
Pontine Tegmentum1.56 ± 0.67
Striatum1.6 ± 0.6
Subthalamus1.63 ± 0.67
Temporal Lobe1.47 ± 0.71
Thalamus1.49 ± 0.7
White Matter1.82 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Il23aCBCerebellum1.42
1.81
Il23aCTXCerebral cortex2.49
2.17
Il23aHIPHippocampal region0.74
1
Il23aHPFHippocampal formation0.52
0.64
Il23aHYHypothalamus0.21
0.2
Il23aLSXLateral septal complex0.09
0.09
Il23aMBMidbrain0.52
0.82
Il23aMYMedulla0.88
1.04
Il23aOLFOlfactory bulb0.6
0.62
Il23aPPons0.42
0.76
Il23aPALPallidum0.17
0.21
Il23aRHPRetrohippocampal region0.17
0.13
Il23asAMYStriatum-like amygdalar nuclei0.17
0.43
Il23aSTRStriatum0.2
0.32
Il23aSTRdStriatum dorsal region0.11
0.1
Il23aSTRvStriatum ventral region0.54
0.99
Il23aTHThalamus0.89
0.98
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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