AutismKB 2.0

Annotation Detail for MED15


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Basic Information Top
Gene Symbol:MED15 ( ARC105,CAG7A,CTG7A,DKFZp686A2214,DKFZp762B1216,FLJ42282,FLJ42935,PCQAP,TIG-1,TIG1,TNRC7 )
Gene Full Name: mediator complex subunit 15
Band: 22q11.21
Quick LinksEntrez ID:51586; OMIM: 607372; Uniprot ID:MED15_HUMAN; ENSEMBL ID: ENSG00000099917; HGNC ID: 14248
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus46 / 56401281
neonate3 / 3109796
infant3 / 23620127
juvenile9 / 55556161
adult236 / 1939121121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor24 / 119369201
germ cell tumor41 / 263845155
glioma17 / 106883159
head and neck tumor30 / 136302220
kidney tumor13 / 68959188
leukemia26 / 95842271
liver tumor12 / 96359124
lung tumor16 / 103127155
lymphoma8 / 71755111
non-neoplasia12 / 97250123
normal344 / 3360307102
ovarian tumor2 / 7668226
pancreatic tumor44 / 104616420
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer10 / 10268097
retinoblastoma4 / 4635686
skin tumor12 / 12494996
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites14 / 40015349
bladder1 / 2975733
blood24 / 123478194
bone13 / 71655181
bone marrow6 / 48801122
brain134 / 1100989121
cervix0 / 481710 
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye21 / 21105499
heart7 / 8962678
intestine26 / 234472110
kidney20 / 21177794
larynx10 / 24145414
liver14 / 20774367
lung56 / 336974166
lymph2 / 4427045
lymph node10 / 91610109
mammary gland7 / 15327145
mouth13 / 67052193
muscle4 / 10771537
nerve2 / 15768126
ovary5 / 10205148
pancreas59 / 214812274
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta43 / 280825153
prostate16 / 18934584
salivary gland1 / 2015549
skin21 / 21057499
spleen9 / 53952166
stomach11 / 96619113
testis44 / 330442133
thymus21 / 81131258
thyroid8 / 47473168
tonsil4 / 16999235
trachea12 / 52413228
umbilical cord2 / 13680146
uterus23 / 23287898
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222175_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts32.5
Adipocyte26.15
AdrenalCortex26.85
Adrenalgland21.25
Amygdala28.95
Appendix26.65
AtrioventricularNode19
BDCA4+_DentriticCells52.45
Bonemarrow26.5
BronchialEpithelialCells27.4
CD105+_Endothelial25.85
CD14+_Monocytes71
CD19+_BCells(neg._sel.)28.6
CD33+_Myeloid66.75
CD34+45.85
CD4+_Tcells85.95
CD56+_NKCells127.6
CD71+_EarlyErythroid23.85
CD8+_Tcells239.2
CardiacMyocytes52.3
Caudatenucleus22.55
Cerebellum20.25
CerebellumPeduncles28.9
CiliaryGanglion17.9
CingulateCortex33.45
Colorectaladenocarcinoma33.4
DorsalRootGanglion18.75
FetalThyroid24.4
Fetalbrain23.95
Fetalliver21.5
Fetallung20.85
GlobusPallidus18.35
Heart32.65
Hypothalamus23.55
Kidney20.8
Leukemia_chronicMyelogenousK-562109.8
Leukemia_promyelocytic-HL-6022.05
Leukemialymphoblastic(MOLT-4)21.2
Liver32.45
Lung146.05
Lymphnode36.7
Lymphoma_burkitts(Daudi)32.35
Lymphoma_burkitts(Raji)48
MedullaOblongata29.8
OccipitalLobe22.9
OlfactoryBulb20.05
Ovary16.35
Pancreas15.5
PancreaticIslet26.85
ParietalLobe26.55
Pituitary29.6
Placenta61.35
Pons23.8
PrefrontalCortex79.35
Prostate40.1
Salivarygland16.45
SkeletalMuscle27.9
Skin18.9
SmoothMuscle53.15
Spinalcord28.05
SubthalamicNucleus21.2
SuperiorCervicalGanglion27.7
TemporalLobe24.4
Testis21.8
TestisGermCell28.25
TestisIntersitial21.25
TestisLeydigCell25.1
TestisSeminiferousTubule21.7
Thalamus25.7
Thymus32.8
Thyroid32.4
Tongue24.3
Tonsil24.95
Trachea21.05
TrigeminalGanglion24.8
Uterus24
UterusCorpus27.45
WholeBlood61.4
Wholebrain32.75
colon28.65
pineal_day89.02
pineal_night101.96
retina60.325
small_intestine24.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10521_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.99 ± 0.61
Basal Forebrain5.37 ± 0.36
Basal Part of Pons5.28 ± 0.54
Cerebellar Cortex4.81 ± 0.49
Cerebellar Nuclei5.08 ± 0.47
Claustrum6.38 ± 0.85
Epithalamus4.37 ± 0.47
Frontal Lobe5.08 ± 0.62
Globus Pallidus5.65 ± 0.28
Hypothalamus4.87 ± 0.54
Insula5.05 ± 0.5
Limbic Lobe5.66 ± 0.67
Mesencephalon5.35 ± 0.66
Myelencephalon5.31 ± 0.61
Occipital Lobe5.67 ± 0.6
Parietal Lobe5.38 ± 0.61
Pontine Tegmentum5.29 ± 0.69
Striatum5.7 ± 0.65
Subthalamus5 ± 0.32
Temporal Lobe5.21 ± 0.59
Thalamus5.12 ± 0.44
White Matter5.73 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PcqapCBCerebellum23.25
28.19
PcqapCTXCerebral cortex45.25
34.24
PcqapHIPHippocampal region30.08
47.77
PcqapHPFHippocampal formation23.94
33.15
PcqapHYHypothalamus2.56
2.74
PcqapLSXLateral septal complex1.5
0.87
PcqapMBMidbrain4.85
4.94
PcqapMYMedulla8.41
8.78
PcqapOLFOlfactory bulb29.35
24.32
PcqapPPons4.82
5.19
PcqapPALPallidum3.5
3.59
PcqapRHPRetrohippocampal region15.63
16.49
PcqapsAMYStriatum-like amygdalar nuclei5.37
3.98
PcqapSTRStriatum9.13
7.18
PcqapSTRdStriatum dorsal region10.6
8.61
PcqapSTRvStriatum ventral region6.04
4.22
PcqapTHThalamus25.43
20.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MED15_HUMAN_0 0 0 0 DLSKMKSLLDILTDPSK PRIDE
MED15_HUMAN_19 10 19 28 LVSQIEDAMR PRIDE
PAp00010098 21 689 709 FLVNLDPSHCSNNGTVHLICK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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