AutismKB 2.0

Annotation Detail for PDK4


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Basic Information Top
Gene Symbol:PDK4 ( FLJ40832 )
Gene Full Name: pyruvate dehydrogenase kinase, isozyme 4
Band: 7q21.3
Quick LinksEntrez ID:5166; OMIM: 602527; Uniprot ID:PDK4_HUMAN; ENSEMBL ID: ENSG00000004799; HGNC ID: 8812
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus20 / 56401235
neonate2 / 3109764
infant0 / 236200 
juvenile5 / 5555689
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor11 / 12794859
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor7 / 34366203
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor2 / 2638457
glioma10 / 10688393
head and neck tumor10 / 13630273
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal364 / 3360307108
ovarian tumor2 / 7668226
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland19 / 33197572
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain133 / 1100989120
cervix8 / 48171166
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus2 / 2020998
eye0 / 2110540 
heart15 / 89626167
intestine14 / 23447259
kidney26 / 211777122
larynx1 / 2414541
liver36 / 207743173
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth9 / 67052134
muscle41 / 107715380
nerve3 / 15768190
ovary3 / 10205129
pancreas49 / 214812228
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta22 / 28082578
prostate22 / 189345116
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach9 / 9661993
testis17 / 33044251
thymus20 / 81131246
thyroid6 / 47473126
tonsil0 / 169990 
trachea98 / 524131869
umbilical cord2 / 13680146
uterus27 / 232878115
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205960_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte31
AdrenalCortex61.05
Adrenalgland9.35
Amygdala5.7
Appendix9.25
AtrioventricularNode5.55
BDCA4+_DentriticCells6.05
Bonemarrow5.35
BronchialEpithelialCells5.4
CD105+_Endothelial5.5
CD14+_Monocytes6.1
CD19+_BCells(neg._sel.)5.85
CD33+_Myeloid7
CD34+7
CD4+_Tcells5.65
CD56+_NKCells6.4
CD71+_EarlyErythroid5.1
CD8+_Tcells4.8
CardiacMyocytes7.15
Caudatenucleus5
Cerebellum4.45
CerebellumPeduncles6.35
CiliaryGanglion4.45
CingulateCortex5.6
Colorectaladenocarcinoma8
DorsalRootGanglion6.4
FetalThyroid5.35
Fetalbrain5.3
Fetalliver4.75
Fetallung4.85
GlobusPallidus4.05
Heart7.25
Hypothalamus5.95
Kidney4.55
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-604.75
Leukemialymphoblastic(MOLT-4)4.3
Liver7.3
Lung6.2
Lymphnode4.8
Lymphoma_burkitts(Daudi)6.95
Lymphoma_burkitts(Raji)7.65
MedullaOblongata5.15
OccipitalLobe5.55
OlfactoryBulb5.05
Ovary250.15
Pancreas38.1
PancreaticIslet469.25
ParietalLobe5.95
Pituitary6.35
Placenta13.5
Pons5.2
PrefrontalCortex7.1
Prostate8.2
Salivarygland5.25
SkeletalMuscle8.1
Skin4.35
SmoothMuscle6.15
Spinalcord5.75
SubthalamicNucleus5
SuperiorCervicalGanglion6.7
TemporalLobe5.05
Testis4.7
TestisGermCell4.55
TestisIntersitial4.65
TestisLeydigCell6.45
TestisSeminiferousTubule4.7
Thalamus5.55
Thymus4.3
Thyroid7
Tongue6.45
Tonsil5.3
Trachea4.6
TrigeminalGanglion6.15
Uterus4.9
UterusCorpus5.55
WholeBlood6.05
Wholebrain5
colon12.65
pineal_day6.88
pineal_night6.78
retina7.075
small_intestine57.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P257087
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.82 ± 0.47
Basal Forebrain4.93 ± 0.4
Basal Part of Pons3.67 ± 0.67
Cerebellar Cortex3.57 ± 0.58
Cerebellar Nuclei3.92 ± 0.73
Claustrum4.44 ± 0.84
Epithalamus4.72 ± 0.52
Frontal Lobe4.16 ± 0.85
Globus Pallidus6.41 ± 0.48
Hypothalamus4.58 ± 0.39
Insula3.93 ± 0.69
Limbic Lobe3.98 ± 0.88
Mesencephalon4.85 ± 0.77
Myelencephalon4.37 ± 0.77
Occipital Lobe4.32 ± 0.67
Parietal Lobe4.22 ± 0.75
Pontine Tegmentum4.58 ± 0.66
Striatum5.41 ± 0.54
Subthalamus3.84 ± 0.34
Temporal Lobe4.16 ± 0.64
Thalamus4.76 ± 0.55
White Matter6.97 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pdk4CBCerebellum1.19
2.28
Pdk4CTXCerebral cortex0.33
0.39
Pdk4HIPHippocampal region0.72
0.89
Pdk4HPFHippocampal formation0.68
0.81
Pdk4HYHypothalamus0.85
1.18
Pdk4LSXLateral septal complex0.54
0.54
Pdk4MBMidbrain0.64
1.07
Pdk4MYMedulla5.74
6.93
Pdk4OLFOlfactory bulb2.1
3.17
Pdk4PPons2.19
2.9
Pdk4PALPallidum0.29
0.24
Pdk4RHPRetrohippocampal region0.34
0.34
Pdk4sAMYStriatum-like amygdalar nuclei1.07
0.9
Pdk4STRStriatum0.74
0.64
Pdk4STRdStriatum dorsal region0.66
0.61
Pdk4STRvStriatum ventral region0.97
0.73
Pdk4THThalamus0.31
0.3
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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