AutismKB 2.0

Annotation Detail for NUB1


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Basic Information Top
Gene Symbol:NUB1 ( BS4,NUB1L,NYREN18 )
Gene Full Name: negative regulator of ubiquitin-like proteins 1
Band: 7q36.1
Quick LinksEntrez ID:51667; OMIM: 607981; Uniprot ID:NUB1_HUMAN; ENSEMBL ID: ENSG00000013374; HGNC ID: 17623
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult161 / 193912183
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor5 / 34366145
chondrosarcoma5 / 8282360
colorectal tumor18 / 114246157
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor16 / 26384560
glioma8 / 10688374
head and neck tumor12 / 13630288
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor7 / 9635972
lung tumor1 / 1031279
lymphoma7 / 7175597
non-neoplasia6 / 9725061
normal173 / 336030751
ovarian tumor4 / 7668252
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer10 / 10268097
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood6 / 12347848
bone4 / 7165555
bone marrow2 / 4880140
brain50 / 110098945
cervix6 / 48171124
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus2 / 2020998
eye14 / 21105466
heart2 / 8962622
intestine26 / 234472110
kidney5 / 21177723
larynx0 / 241450 
liver10 / 20774348
lung25 / 33697474
lymph2 / 4427045
lymph node4 / 9161043
mammary gland14 / 15327191
mouth5 / 6705274
muscle5 / 10771546
nerve1 / 1576863
ovary6 / 10205158
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland2 / 16585120
placenta15 / 28082553
prostate13 / 18934568
salivary gland0 / 201550 
skin7 / 21057433
spleen1 / 5395218
stomach10 / 96619103
testis22 / 33044266
thymus3 / 8113136
thyroid6 / 47473126
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus22 / 23287894
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5731_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.2 ± 0.4
Basal Forebrain6.72 ± 0.21
Basal Part of Pons6.89 ± 0.32
Cerebellar Cortex6.85 ± 0.22
Cerebellar Nuclei7.16 ± 0.34
Claustrum6.36 ± 0.6
Epithalamus6.97 ± 0.41
Frontal Lobe6.57 ± 0.4
Globus Pallidus7.24 ± 0.2
Hypothalamus7.07 ± 0.26
Insula6.48 ± 0.42
Limbic Lobe6.39 ± 0.44
Mesencephalon6.71 ± 0.38
Myelencephalon6.66 ± 0.4
Occipital Lobe6.88 ± 0.31
Parietal Lobe6.75 ± 0.4
Pontine Tegmentum6.68 ± 0.34
Striatum6.15 ± 0.37
Subthalamus6.54 ± 0.88
Temporal Lobe6.6 ± 0.36
Thalamus6.81 ± 0.29
White Matter7.75 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nub1CBCerebellum37.85
46.88
Nub1CTXCerebral cortex100
100
Nub1HIPHippocampal region64.5
100
Nub1HPFHippocampal formation87.32
100
Nub1HYHypothalamus69.58
64.32
Nub1LSXLateral septal complex68.1
56.86
Nub1MBMidbrain66.36
66.55
Nub1MYMedulla63.14
74.88
Nub1OLFOlfactory bulb93.38
87.2
Nub1PPons53.18
62.79
Nub1PALPallidum58.38
58.67
Nub1RHPRetrohippocampal region100
100
Nub1sAMYStriatum-like amygdalar nuclei94.86
82.26
Nub1STRStriatum98.52
83.2
Nub1STRdStriatum dorsal region100
89.05
Nub1STRvStriatum ventral region87.88
72.24
Nub1THThalamus67.86
62.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039305 16 399 414 ACDGNVDHAATHITNR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018