AutismKB 2.0

Annotation Detail for TPPP3


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Basic Information Top
Gene Symbol:TPPP3 ( p20,p25gamma )
Gene Full Name: tubulin polymerization-promoting protein family member 3
Band: 16q22.1
Quick LinksEntrez ID:51673; OMIM: NA; Uniprot ID:TPPP3_HUMAN; ENSEMBL ID: ENSG00000159713; HGNC ID: 24162
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult99 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor10 / 13630273
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal159 / 336030747
ovarian tumor0 / 766820 
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain121 / 1100989109
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye6 / 21105428
heart7 / 8962678
intestine7 / 23447229
kidney2 / 2117779
larynx9 / 24145372
liver0 / 2077430 
lung25 / 33697474
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle7 / 10771564
nerve6 / 15768380
ovary1 / 1020519
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta34 / 280825121
prostate2 / 18934510
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218876_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.5
Adipocyte5.25
AdrenalCortex5.65
Adrenalgland4.65
Amygdala5.7
Appendix5.4
AtrioventricularNode4.15
BDCA4+_DentriticCells5.8
Bonemarrow5.25
BronchialEpithelialCells5.25
CD105+_Endothelial5.35
CD14+_Monocytes15.4
CD19+_BCells(neg._sel.)5.75
CD33+_Myeloid7.3
CD34+6.85
CD4+_Tcells5.75
CD56+_NKCells6.3
CD71+_EarlyErythroid5
CD8+_Tcells5.1
CardiacMyocytes6.7
Caudatenucleus10.45
Cerebellum4.45
CerebellumPeduncles6.2
CiliaryGanglion6
CingulateCortex8.05
Colorectaladenocarcinoma5.35
DorsalRootGanglion13.2
FetalThyroid5.1
Fetalbrain5.2
Fetalliver4.65
Fetallung13.3
GlobusPallidus4.75
Heart6.85
Hypothalamus19.45
Kidney4.4
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.25
Liver7.05
Lung10.9
Lymphnode4.55
Lymphoma_burkitts(Daudi)7
Lymphoma_burkitts(Raji)7.5
MedullaOblongata8.65
OccipitalLobe12.75
OlfactoryBulb5.1
Ovary3.5
Pancreas4.3
PancreaticIslet30.85
ParietalLobe15.35
Pituitary6.55
Placenta269.4
Pons11.5
PrefrontalCortex12.6
Prostate6.2
Salivarygland4.3
SkeletalMuscle6.25
Skin4.35
SmoothMuscle6
Spinalcord14.35
SubthalamicNucleus5.5
SuperiorCervicalGanglion6.4
TemporalLobe8.05
Testis4.5
TestisGermCell4.45
TestisIntersitial4.5
TestisLeydigCell5.3
TestisSeminiferousTubule4.55
Thalamus18.35
Thymus4.1
Thyroid6.7
Tongue11.6
Tonsil5.2
Trachea8.65
TrigeminalGanglion5.55
Uterus4.4
UterusCorpus4.8
WholeBlood5.8
Wholebrain19.7
colon5.3
pineal_day9.02
pineal_night7.3
retina64.525
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10201_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.17 ± 0.85
Basal Forebrain9.19 ± 0.49
Basal Part of Pons8.72 ± 0.48
Cerebellar Cortex8.1 ± 0.41
Cerebellar Nuclei8.81 ± 0.89
Claustrum9.27 ± 0.52
Epithalamus10.71 ± 1
Frontal Lobe8.85 ± 0.8
Globus Pallidus10.28 ± 0.28
Hypothalamus9.5 ± 0.56
Insula8.75 ± 0.5
Limbic Lobe8.37 ± 1.05
Mesencephalon8.84 ± 0.57
Myelencephalon8.94 ± 0.78
Occipital Lobe8.35 ± 0.76
Parietal Lobe8.29 ± 0.75
Pontine Tegmentum8.81 ± 0.8
Striatum9.06 ± 1.07
Subthalamus8.17 ± 0.17
Temporal Lobe8.46 ± 0.72
Thalamus9.14 ± 0.46
White Matter11.81 ± 0.93
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
2700055K07RikCBCerebellum54.21
75.93
2700055K07RikCTXCerebral cortex41.42
35.26
2700055K07RikHIPHippocampal region42.36
46.74
2700055K07RikHPFHippocampal formation48.1
47.83
2700055K07RikHYHypothalamus87.15
96.48
2700055K07RikLSXLateral septal complex92.91
93.86
2700055K07RikMBMidbrain83.38
88.98
2700055K07RikMYMedulla96
100
2700055K07RikOLFOlfactory bulb50.37
45.18
2700055K07RikPPons98.2
100
2700055K07RikPALPallidum77.28
82.81
2700055K07RikRHPRetrohippocampal region62.29
52.56
2700055K07RiksAMYStriatum-like amygdalar nuclei85.14
89.61
2700055K07RikSTRStriatum58.47
59.99
2700055K07RikSTRdStriatum dorsal region51.4
51.69
2700055K07RikSTRvStriatum ventral region34.72
29.62
2700055K07RikTHThalamus73.86
74.05
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00077578 16 91 106 SKEEAFDAICQLVAGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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