AutismKB 2.0

Annotation Detail for MPP6


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Basic Information Top
Gene Symbol:MPP6 ( PALS2,VAM-1,VAM1,p55T )
Gene Full Name: membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Band: 7p15.3
Quick LinksEntrez ID:51678; OMIM: 606959; Uniprot ID:MPP6_HUMAN; ENSEMBL ID: ENSG00000105926; HGNC ID: 18167
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain8 / 11009897
cervix1 / 4817120
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine5 / 23447221
kidney5 / 21177723
larynx0 / 241450 
liver12 / 20774357
lung4 / 33697411
lymph0 / 442700 
lymph node4 / 9161043
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205429_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.2
Adipocyte4.55
AdrenalCortex5.05
Adrenalgland3.9
Amygdala4.8
Appendix4.75
AtrioventricularNode3.75
BDCA4+_DentriticCells5
Bonemarrow4.55
BronchialEpithelialCells4.45
CD105+_Endothelial4.7
CD14+_Monocytes4.85
CD19+_BCells(neg._sel.)10.55
CD33+_Myeloid5.8
CD34+6.75
CD4+_Tcells4.85
CD56+_NKCells5.5
CD71+_EarlyErythroid4.3
CD8+_Tcells4.3
CardiacMyocytes6.3
Caudatenucleus4.1
Cerebellum3.7
CerebellumPeduncles5.25
CiliaryGanglion3.4
CingulateCortex4.7
Colorectaladenocarcinoma6.9
DorsalRootGanglion3.65
FetalThyroid4.55
Fetalbrain4.45
Fetalliver3.95
Fetallung3.7
GlobusPallidus3.45
Heart6.35
Hypothalamus4.9
Kidney3.75
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-606
Leukemialymphoblastic(MOLT-4)3.65
Liver6.2
Lung5
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.85
Lymphoma_burkitts(Raji)6.7
MedullaOblongata4.2
OccipitalLobe4.1
OlfactoryBulb3.65
Ovary3.05
Pancreas3.8
PancreaticIslet5.05
ParietalLobe4.85
Pituitary5.3
Placenta4.65
Pons4.4
PrefrontalCortex5.6
Prostate5.35
Salivarygland3.7
SkeletalMuscle5.75
Skin3.55
SmoothMuscle5.2
Spinalcord4.9
SubthalamicNucleus4.3
SuperiorCervicalGanglion6.1
TemporalLobe4.2
Testis5.7
TestisGermCell24.6
TestisIntersitial12.3
TestisLeydigCell7.85
TestisSeminiferousTubule4.6
Thalamus4.65
Thymus3.55
Thyroid5.65
Tongue4.5
Tonsil4.45
Trachea3.8
TrigeminalGanglion5.5
Uterus3.7
UterusCorpus4.2
WholeBlood5
Wholebrain3.85
colon4.6
pineal_day5.66
pineal_night5.52
retina5.55
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5724_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.89 ± 0.22
Basal Forebrain8.86 ± 0.21
Basal Part of Pons8.14 ± 0.17
Cerebellar Cortex8.21 ± 0.24
Cerebellar Nuclei8.43 ± 0.27
Claustrum8.87 ± 0.41
Epithalamus8.87 ± 0.45
Frontal Lobe8.7 ± 0.4
Globus Pallidus8.98 ± 0.17
Hypothalamus8.56 ± 0.26
Insula8.73 ± 0.25
Limbic Lobe8.94 ± 0.28
Mesencephalon8.58 ± 0.45
Myelencephalon8.59 ± 0.39
Occipital Lobe8.23 ± 0.38
Parietal Lobe8.64 ± 0.44
Pontine Tegmentum8.76 ± 0.49
Striatum9.3 ± 0.3
Subthalamus8.76 ± 0.06
Temporal Lobe8.55 ± 0.32
Thalamus8.23 ± 0.45
White Matter7.7 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mpp6CBCerebellum5.62
6.17
Mpp6CTXCerebral cortex1.28
1.09
Mpp6HIPHippocampal region1.15
1.19
Mpp6HPFHippocampal formation1.17
1.05
Mpp6HYHypothalamus0.58
0.64
Mpp6LSXLateral septal complex0.07
0.04
Mpp6MBMidbrain0.48
0.85
Mpp6MYMedulla0.65
0.76
Mpp6OLFOlfactory bulb0.2
0.15
Mpp6PPons0.36
0.38
Mpp6PALPallidum0.91
0.97
Mpp6RHPRetrohippocampal region1.28
0.91
Mpp6sAMYStriatum-like amygdalar nuclei0.18
0.2
Mpp6STRStriatum0.27
0.21
Mpp6STRdStriatum dorsal region0.33
0.25
Mpp6STRvStriatum ventral region0.18
0.19
Mpp6THThalamus0.58
0.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MPP6_HUMAN_353 13 353 365 SLKNRFIVLNPTR PRIDE
PAp00040686 11 322 332 HEIQIYEEVAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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