AutismKB 2.0

Annotation Detail for ENPP2


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Basic Information Top
Gene Symbol:ENPP2 ( ATX,ATX-X,AUTOTAXIN,FLJ26803,LysoPLD,NPP2,PD-IALPHA,PDNP2 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Band: 8q24.12
Quick LinksEntrez ID:5168; OMIM: 601060; Uniprot ID:ENPP2_HUMAN; ENSEMBL ID: ENSG00000136960; HGNC ID: 3357
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult209 / 1939121107
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal386 / 3360307114
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow2 / 4880140
brain232 / 1100989210
cervix0 / 481710 
connective tissue6 / 14925540
ear3 / 16212185
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye25 / 211054118
heart3 / 8962633
intestine9 / 23447238
kidney11 / 21177751
larynx0 / 241450 
liver5 / 20774324
lung12 / 33697435
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve4 / 15768253
ovary1 / 1020519
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland2 / 16585120
placenta42 / 280825149
prostate2 / 18934510
salivary gland0 / 201550 
skin3 / 21057414
spleen2 / 5395237
stomach2 / 9661920
testis14 / 33044242
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210839_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.5
Adipocyte24.8
AdrenalCortex6.1
Adrenalgland16
Amygdala304.25
Appendix12.3
AtrioventricularNode4.55
BDCA4+_DentriticCells11.1
Bonemarrow5.35
BronchialEpithelialCells5.3
CD105+_Endothelial5
CD14+_Monocytes5.5
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid6.2
CD34+6.7
CD4+_Tcells5.4
CD56+_NKCells5.6
CD71+_EarlyErythroid4.5
CD8+_Tcells5
CardiacMyocytes7
Caudatenucleus460.45
Cerebellum36
CerebellumPeduncles96.55
CiliaryGanglion5.25
CingulateCortex235.45
Colorectaladenocarcinoma4.85
DorsalRootGanglion5
FetalThyroid5.55
Fetalbrain5.15
Fetalliver11.8
Fetallung88.5
GlobusPallidus72.35
Heart6.85
Hypothalamus878.7
Kidney28.6
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)3.9
Liver7.2
Lung79.45
Lymphnode64.7
Lymphoma_burkitts(Daudi)6.55
Lymphoma_burkitts(Raji)7.75
MedullaOblongata438.45
OccipitalLobe509.4
OlfactoryBulb35.4
Ovary25.05
Pancreas19.75
PancreaticIslet218.8
ParietalLobe644.2
Pituitary11.7
Placenta106.55
Pons158.5
PrefrontalCortex157.7
Prostate7.05
Salivarygland9.3
SkeletalMuscle7.65
Skin4.8
SmoothMuscle5.85
Spinalcord906.65
SubthalamicNucleus106.25
SuperiorCervicalGanglion7.3
TemporalLobe40.25
Testis7.9
TestisGermCell40.75
TestisIntersitial24.4
TestisLeydigCell10.55
TestisSeminiferousTubule13.75
Thalamus874.65
Thymus7.45
Thyroid6.8
Tongue6
Tonsil155
Trachea4.7
TrigeminalGanglion5.7
Uterus111.95
UterusCorpus192.2
WholeBlood5.7
Wholebrain263.7
colon6.4
pineal_day6.84
pineal_night163.44
retina959.95
small_intestine29.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14963_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.02 ± 1.05
Basal Forebrain9.81 ± 0.87
Basal Part of Pons9.34 ± 0.74
Cerebellar Cortex8.41 ± 0.59
Cerebellar Nuclei10.95 ± 0.86
Claustrum8.69 ± 0.85
Epithalamus8.73 ± 1.37
Frontal Lobe9.04 ± 1.25
Globus Pallidus11.57 ± 0.41
Hypothalamus8.63 ± 0.76
Insula8.11 ± 0.88
Limbic Lobe8.38 ± 1.17
Mesencephalon9.41 ± 1.11
Myelencephalon9.26 ± 0.95
Occipital Lobe9.16 ± 1.02
Parietal Lobe8.84 ± 1.31
Pontine Tegmentum9.44 ± 0.74
Striatum10.1 ± 1.03
Subthalamus9.83 ± 0.89
Temporal Lobe8.71 ± 1.05
Thalamus10 ± 0.58
White Matter13.15 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Enpp2CBCerebellum85.62
100
Enpp2CTXCerebral cortex100
100
Enpp2HIPHippocampal region59.08
80.91
Enpp2HPFHippocampal formation68.81
87.08
Enpp2HYHypothalamus95.1
96.53
Enpp2LSXLateral septal complex100
100
Enpp2MBMidbrain100
100
Enpp2MYMedulla100
100
Enpp2OLFOlfactory bulb86.25
96.05
Enpp2PPons100
100
Enpp2PALPallidum100
100
Enpp2RHPRetrohippocampal region82.8
90.38
Enpp2sAMYStriatum-like amygdalar nuclei88.28
87.27
Enpp2STRStriatum90.87
92.22
Enpp2STRdStriatum dorsal region96
100
Enpp2STRvStriatum ventral region65.87
59.07
Enpp2THThalamus94.59
96.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00092103 12 829 840 DIEHLTSLDFFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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