AutismKB 2.0

Annotation Detail for PDPK1


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Basic Information Top
Gene Symbol:PDPK1 ( MGC20087,MGC35290,PDK1,PRO0461 )
Gene Full Name: 3-phosphoinositide dependent protein kinase-1
Band: 16p13.3
Quick LinksEntrez ID:5170; OMIM: 605213; Uniprot ID:PDPK1_HUMAN; ENSEMBL ID: ENSG00000140992; HGNC ID: 8816
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus41 / 56401272
neonate2 / 3109764
infant3 / 23620127
juvenile2 / 5555635
adult163 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor20 / 114246175
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor34 / 263845128
glioma12 / 106883112
head and neck tumor12 / 13630288
kidney tumor5 / 6895972
leukemia8 / 9584283
liver tumor8 / 9635983
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal278 / 336030782
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer7 / 10268068
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood8 / 12347864
bone2 / 7165527
bone marrow2 / 4880140
brain104 / 110098994
cervix2 / 4817141
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus1 / 2020949
eye19 / 21105490
heart3 / 8962633
intestine34 / 234472145
kidney19 / 21177789
larynx0 / 241450 
liver17 / 20774381
lung27 / 33697480
lymph2 / 4427045
lymph node22 / 91610240
mammary gland6 / 15327139
mouth8 / 67052119
muscle5 / 10771546
nerve0 / 157680 
ovary2 / 10205119
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta24 / 28082585
prostate12 / 18934563
salivary gland0 / 201550 
skin13 / 21057461
spleen1 / 5395218
stomach9 / 9661993
testis38 / 330442114
thymus8 / 8113198
thyroid6 / 47473126
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 32029_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.7
Adipocyte8.15
AdrenalCortex13.1
Adrenalgland6.9
Amygdala8.5
Appendix8.35
AtrioventricularNode8.15
BDCA4+_DentriticCells16.9
Bonemarrow7.8
BronchialEpithelialCells8.4
CD105+_Endothelial14.25
CD14+_Monocytes13.65
CD19+_BCells(neg._sel.)10.3
CD33+_Myeloid37.4
CD34+30.5
CD4+_Tcells9.85
CD56+_NKCells21.95
CD71+_EarlyErythroid20.05
CD8+_Tcells8.3
CardiacMyocytes10.35
Caudatenucleus5.75
Cerebellum6.35
CerebellumPeduncles9.45
CiliaryGanglion5.9
CingulateCortex8.8
Colorectaladenocarcinoma8.35
DorsalRootGanglion6.2
FetalThyroid14.9
Fetalbrain8.4
Fetalliver7.15
Fetallung6.7
GlobusPallidus6.8
Heart11.85
Hypothalamus8.05
Kidney6.7
Leukemia_chronicMyelogenousK-5627.4
Leukemia_promyelocytic-HL-607.25
Leukemialymphoblastic(MOLT-4)6.4
Liver13.55
Lung10.55
Lymphnode5.55
Lymphoma_burkitts(Daudi)10.15
Lymphoma_burkitts(Raji)11.4
MedullaOblongata7.75
OccipitalLobe7.4
OlfactoryBulb6.65
Ovary5.5
Pancreas6.65
PancreaticIslet8.85
ParietalLobe9.7
Pituitary9.9
Placenta8.85
Pons8.3
PrefrontalCortex10.6
Prostate19.35
Salivarygland6.65
SkeletalMuscle16.25
Skin7
SmoothMuscle9.65
Spinalcord8.75
SubthalamicNucleus10.35
SuperiorCervicalGanglion9.05
TemporalLobe10.95
Testis7.4
TestisGermCell8.7
TestisIntersitial15.15
TestisLeydigCell8.65
TestisSeminiferousTubule7.5
Thalamus7.3
Thymus6.75
Thyroid10.4
Tongue16.15
Tonsil7.95
Trachea6.75
TrigeminalGanglion10.05
Uterus7.05
UterusCorpus9.75
WholeBlood9.05
Wholebrain7.5
colon8.6
pineal_day19.72
pineal_night11.72
retina10.2
small_intestine8.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P830690
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.34 ± 0.6
Basal Forebrain4.97 ± 0.47
Basal Part of Pons5.74 ± 0.31
Cerebellar Cortex5.52 ± 0.37
Cerebellar Nuclei4.88 ± 0.53
Claustrum4.67 ± 0.7
Epithalamus5 ± 0.63
Frontal Lobe5.39 ± 0.56
Globus Pallidus4.32 ± 0.66
Hypothalamus5.54 ± 0.65
Insula5.53 ± 0.31
Limbic Lobe5.29 ± 0.58
Mesencephalon5.11 ± 0.46
Myelencephalon5.18 ± 0.6
Occipital Lobe4.92 ± 0.58
Parietal Lobe5.27 ± 0.42
Pontine Tegmentum5.29 ± 0.56
Striatum5.16 ± 0.52
Subthalamus5.13 ± 0.7
Temporal Lobe5.49 ± 0.5
Thalamus5.01 ± 0.45
White Matter4.72 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pdpk1CBCerebellum17.63
20.64
Pdpk1CTXCerebral cortex86.6
76.02
Pdpk1HIPHippocampal region59.6
100
Pdpk1HPFHippocampal formation50.65
72.21
Pdpk1HYHypothalamus15.55
13.77
Pdpk1LSXLateral septal complex22.78
19.38
Pdpk1MBMidbrain24.66
25.16
Pdpk1MYMedulla28.18
35.32
Pdpk1OLFOlfactory bulb47.6
43.12
Pdpk1PPons25.7
32.63
Pdpk1PALPallidum23.19
24.12
Pdpk1RHPRetrohippocampal region36.47
33.57
Pdpk1sAMYStriatum-like amygdalar nuclei38.1
32.36
Pdpk1STRStriatum83.41
70.44
Pdpk1STRdStriatum dorsal region100
87.75
Pdpk1STRvStriatum ventral region76.35
62.05
Pdpk1THThalamus20.47
18.97
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00133396 20 211 230 AHPFFESVTWENLHQQTPPK Peptide Atlas
PDPK1_HUMAN_60 16 60 75 PGAGSLQHAQPPPQPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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