AutismKB 2.0

Annotation Detail for NLK


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Basic Information Top
Gene Symbol:NLK ( DKFZp761G1211,FLJ21033 )
Gene Full Name: nemo-like kinase
Band: 17q11.2
Quick LinksEntrez ID:51701; OMIM: 609476; Uniprot ID:NLK_HUMAN; ENSEMBL ID: ENSG00000087095; HGNC ID: 29858
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma0 / 1068830 
head and neck tumor7 / 13630251
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia11 / 97250113
normal104 / 336030730
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma11 / 46356237
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain36 / 110098932
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye31 / 211054146
heart1 / 8962611
intestine8 / 23447234
kidney11 / 21177751
larynx1 / 2414541
liver3 / 20774314
lung12 / 33697435
lymph0 / 442700 
lymph node17 / 91610185
mammary gland1 / 1532716
mouth4 / 6705259
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid7 / 20539340
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate4 / 18934521
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach2 / 9661920
testis8 / 33044224
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218318_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.9
Adipocyte6.75
AdrenalCortex8
Adrenalgland6.95
Amygdala38.4
Appendix7.65
AtrioventricularNode5.95
BDCA4+_DentriticCells8.15
Bonemarrow7.5
BronchialEpithelialCells6.7
CD105+_Endothelial7.25
CD14+_Monocytes7.4
CD19+_BCells(neg._sel.)7.15
CD33+_Myeloid8.45
CD34+10.45
CD4+_Tcells7.5
CD56+_NKCells7.9
CD71+_EarlyErythroid8.85
CD8+_Tcells6.35
CardiacMyocytes9.65
Caudatenucleus6.65
Cerebellum5.7
CerebellumPeduncles8.55
CiliaryGanglion5.9
CingulateCortex38.3
Colorectaladenocarcinoma30.95
DorsalRootGanglion5.85
FetalThyroid7.15
Fetalbrain7.4
Fetalliver6.35
Fetallung5.85
GlobusPallidus6.2
Heart9.95
Hypothalamus8.6
Kidney5.95
Leukemia_chronicMyelogenousK-5627.3
Leukemia_promyelocytic-HL-606
Leukemialymphoblastic(MOLT-4)7.6
Liver10.6
Lung7.5
Lymphnode5.95
Lymphoma_burkitts(Daudi)8.95
Lymphoma_burkitts(Raji)10.4
MedullaOblongata13.2
OccipitalLobe12.7
OlfactoryBulb5.85
Ovary4.85
Pancreas5.75
PancreaticIslet7.65
ParietalLobe16.5
Pituitary8.15
Placenta7.2
Pons7.35
PrefrontalCortex21.9
Prostate7.95
Salivarygland5.65
SkeletalMuscle8.75
Skin6.1
SmoothMuscle7.85
Spinalcord8.5
SubthalamicNucleus8.95
SuperiorCervicalGanglion8.35
TemporalLobe8.8
Testis5.95
TestisGermCell5.85
TestisIntersitial5.9
TestisLeydigCell7.3
TestisSeminiferousTubule5.85
Thalamus7.4
Thymus5.25
Thyroid9.35
Tongue7.05
Tonsil7.15
Trachea5.65
TrigeminalGanglion10
Uterus5.5
UterusCorpus6.45
WholeBlood7.85
Wholebrain43.3
colon7.15
pineal_day25.76
pineal_night52.5
retina11.65
small_intestine6.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14820_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.42 ± 0.74
Basal Forebrain7.64 ± 0.38
Basal Part of Pons7.29 ± 0.38
Cerebellar Cortex7.31 ± 0.19
Cerebellar Nuclei7.66 ± 0.29
Claustrum8.09 ± 0.53
Epithalamus7.23 ± 0.46
Frontal Lobe7.84 ± 0.43
Globus Pallidus7.2 ± 0.61
Hypothalamus7.5 ± 0.31
Insula7.74 ± 0.27
Limbic Lobe7.69 ± 0.42
Mesencephalon7.74 ± 0.47
Myelencephalon7.67 ± 0.44
Occipital Lobe7.78 ± 0.53
Parietal Lobe7.98 ± 0.49
Pontine Tegmentum7.72 ± 0.53
Striatum7.03 ± 0.75
Subthalamus7.26 ± 0.5
Temporal Lobe7.92 ± 0.35
Thalamus7.52 ± 0.36
White Matter7.53 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NlkCBCerebellum24.85
38.26
NlkCTXCerebral cortex100
100
NlkHIPHippocampal region40.63
38.01
NlkHPFHippocampal formation82.33
71.12
NlkHYHypothalamus5.56
3.04
NlkLSXLateral septal complex24.11
10.68
NlkMBMidbrain18.64
12.5
NlkMYMedulla31.52
28.3
NlkOLFOlfactory bulb100
100
NlkPPons20.36
13.1
NlkPALPallidum37.25
24.23
NlkRHPRetrohippocampal region84.42
86.3
NlksAMYStriatum-like amygdalar nuclei19.93
12.57
NlkSTRStriatum48.11
20.58
NlkSTRdStriatum dorsal region49.31
19.67
NlkSTRvStriatum ventral region65.25
30.56
NlkTHThalamus10.42
6.24
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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