AutismKB 2.0

Annotation Detail for POLR3K


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Basic Information Top
Gene Symbol:POLR3K ( C11,C11-RNP3,RPC10,RPC11,RPC12.5,hRPC11 )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Band: 16p13.3
Quick LinksEntrez ID:51728; OMIM: 606007; Uniprot ID:RPC10_HUMAN; ENSEMBL ID: ENSG00000161980; HGNC ID: 14121
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus12 / 56401221
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal48 / 336030714
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow2 / 4880140
brain7 / 11009896
cervix2 / 4817141
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine6 / 23447225
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung9 / 33697426
lymph1 / 4427022
lymph node1 / 9161010
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate5 / 18934526
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218866_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts285.65
Adipocyte34.65
AdrenalCortex22.6
Adrenalgland22.8
Amygdala37.7
Appendix19.1
AtrioventricularNode8.85
BDCA4+_DentriticCells42.1
Bonemarrow32.65
BronchialEpithelialCells33.85
CD105+_Endothelial104
CD14+_Monocytes59
CD19+_BCells(neg._sel.)83.2
CD33+_Myeloid39.3
CD34+171.65
CD4+_Tcells39
CD56+_NKCells69
CD71+_EarlyErythroid80.65
CD8+_Tcells51.85
CardiacMyocytes57.8
Caudatenucleus28.05
Cerebellum32.75
CerebellumPeduncles73.7
CiliaryGanglion5.7
CingulateCortex21.85
Colorectaladenocarcinoma63.7
DorsalRootGanglion6.05
FetalThyroid12
Fetalbrain13.95
Fetalliver27.25
Fetallung11.5
GlobusPallidus25.55
Heart78.15
Hypothalamus43.05
Kidney20.8
Leukemia_chronicMyelogenousK-56289.05
Leukemia_promyelocytic-HL-60207.9
Leukemialymphoblastic(MOLT-4)128.35
Liver29.1
Lung26
Lymphnode17.3
Lymphoma_burkitts(Daudi)216.05
Lymphoma_burkitts(Raji)84.6
MedullaOblongata25.4
OccipitalLobe37
OlfactoryBulb18.2
Ovary14.65
Pancreas18.95
PancreaticIslet33.6
ParietalLobe32.4
Pituitary19.3
Placenta15.8
Pons29.75
PrefrontalCortex22.65
Prostate21.9
Salivarygland23.9
SkeletalMuscle31.1
Skin7.1
SmoothMuscle29
Spinalcord29.2
SubthalamicNucleus16.55
SuperiorCervicalGanglion32.65
TemporalLobe34.6
Testis17.7
TestisGermCell15.25
TestisIntersitial21.15
TestisLeydigCell15.95
TestisSeminiferousTubule16.35
Thalamus29.9
Thymus32.85
Thyroid20.4
Tongue8.95
Tonsil30.35
Trachea22.05
TrigeminalGanglion26.75
Uterus10.5
UterusCorpus25.15
WholeBlood32.2
Wholebrain65.8
colon29.15
pineal_day49.9
pineal_night55.58
retina47.1
small_intestine38.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10183_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.33 ± 0.38
Basal Forebrain4.82 ± 0.38
Basal Part of Pons5.27 ± 0.45
Cerebellar Cortex5.26 ± 0.5
Cerebellar Nuclei4.58 ± 0.42
Claustrum4.69 ± 0.55
Epithalamus4.5 ± 0.3
Frontal Lobe5.21 ± 0.37
Globus Pallidus4.44 ± 0.39
Hypothalamus4.96 ± 0.52
Insula5.27 ± 0.47
Limbic Lobe5.15 ± 0.43
Mesencephalon4.85 ± 0.47
Myelencephalon4.97 ± 0.54
Occipital Lobe4.52 ± 0.5
Parietal Lobe5 ± 0.4
Pontine Tegmentum4.96 ± 0.51
Striatum4.48 ± 0.38
Subthalamus4.79 ± 0.35
Temporal Lobe5.19 ± 0.48
Thalamus4.88 ± 0.45
White Matter4.47 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Polr3kCBCerebellum19.1
51.14
Polr3kCTXCerebral cortex10.34
7.56
Polr3kHIPHippocampal region10.84
10.67
Polr3kHPFHippocampal formation14.27
12.52
Polr3kHYHypothalamus6.46
6.16
Polr3kLSXLateral septal complex3.18
2.02
Polr3kMBMidbrain7.54
7.33
Polr3kMYMedulla14.69
17.79
Polr3kOLFOlfactory bulb9.91
8.3
Polr3kPPons8.53
9.61
Polr3kPALPallidum2.07
1.79
Polr3kRHPRetrohippocampal region20.2
15.3
Polr3ksAMYStriatum-like amygdalar nuclei1.13
0.98
Polr3kSTRStriatum2.1
1.71
Polr3kSTRdStriatum dorsal region2.31
2.01
Polr3kSTRvStriatum ventral region1.58
1.04
Polr3kTHThalamus4.05
3.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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