AutismKB 2.0

Annotation Detail for WWOX


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Basic Information Top
Gene Symbol:WWOX ( D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1 )
Gene Full Name: WW domain containing oxidoreductase
Band: 16q23.1-q23.2
Quick LinksEntrez ID:51741; OMIM: 605131; Uniprot ID:WWOX_HUMAN; ENSEMBL ID: ENSG00000186153; HGNC ID: 12799
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus23 / 56401240
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor17 / 26384564
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor5 / 6895972
leukemia5 / 9584252
liver tumor2 / 9635920
lung tumor6 / 10312758
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal135 / 336030740
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood6 / 12347848
bone1 / 7165513
bone marrow0 / 488010 
brain78 / 110098970
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine3 / 23447212
kidney21 / 21177799
larynx0 / 241450 
liver5 / 20774324
lung19 / 33697456
lymph1 / 4427022
lymph node0 / 916100 
mammary gland10 / 15327165
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta22 / 28082578
prostate9 / 18934547
salivary gland2 / 2015599
skin2 / 2105749
spleen4 / 5395274
stomach0 / 966190 
testis10 / 33044230
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219077_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.75
Adipocyte6.8
AdrenalCortex6.1
Adrenalgland7.4
Amygdala48.6
Appendix18.75
AtrioventricularNode7.2
BDCA4+_DentriticCells18.7
Bonemarrow6.05
BronchialEpithelialCells6.15
CD105+_Endothelial10.5
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)19.85
CD33+_Myeloid11.4
CD34+47.25
CD4+_Tcells7.7
CD56+_NKCells13.5
CD71+_EarlyErythroid4.5
CD8+_Tcells8.55
CardiacMyocytes6.85
Caudatenucleus17.8
Cerebellum32.35
CerebellumPeduncles6.9
CiliaryGanglion4.6
CingulateCortex10.55
Colorectaladenocarcinoma8.9
DorsalRootGanglion10.8
FetalThyroid29.25
Fetalbrain6.15
Fetalliver20.05
Fetallung5.4
GlobusPallidus5.05
Heart8.35
Hypothalamus63.35
Kidney17.25
Leukemia_chronicMyelogenousK-5626.25
Leukemia_promyelocytic-HL-606.55
Leukemialymphoblastic(MOLT-4)20.05
Liver19.05
Lung7.35
Lymphnode4.65
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)8.3
MedullaOblongata11.4
OccipitalLobe11.2
OlfactoryBulb10.4
Ovary5.4
Pancreas6.4
PancreaticIslet8.8
ParietalLobe7.7
Pituitary11.4
Placenta7.6
Pons7.15
PrefrontalCortex27.9
Prostate13.6
Salivarygland6.1
SkeletalMuscle7.3
Skin7.15
SmoothMuscle5.85
Spinalcord76.25
SubthalamicNucleus5.4
SuperiorCervicalGanglion22.45
TemporalLobe7.25
Testis13.05
TestisGermCell7.55
TestisIntersitial7.45
TestisLeydigCell9.1
TestisSeminiferousTubule6.9
Thalamus12.5
Thymus15.55
Thyroid121.5
Tongue5.55
Tonsil5.85
Trachea11.5
TrigeminalGanglion10.25
Uterus9.2
UterusCorpus4.65
WholeBlood5.8
Wholebrain53.2
colon7.15
pineal_day12.26
pineal_night14.36
retina61
small_intestine11.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16727_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.32 ± 0.37
Basal Forebrain9.53 ± 0.44
Basal Part of Pons9.34 ± 0.3
Cerebellar Cortex9.65 ± 0.24
Cerebellar Nuclei9.74 ± 0.3
Claustrum9.28 ± 0.33
Epithalamus10.22 ± 0.34
Frontal Lobe9.13 ± 0.47
Globus Pallidus10.18 ± 0.43
Hypothalamus9.26 ± 0.4
Insula9.06 ± 0.61
Limbic Lobe9.14 ± 0.54
Mesencephalon9.46 ± 0.37
Myelencephalon9.37 ± 0.54
Occipital Lobe9.61 ± 0.59
Parietal Lobe9.22 ± 0.42
Pontine Tegmentum9.33 ± 0.4
Striatum9.4 ± 0.57
Subthalamus9.28 ± 0.19
Temporal Lobe9.14 ± 0.4
Thalamus9.46 ± 0.29
White Matter10.54 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
WwoxCBCerebellum12.81
13.58
WwoxCTXCerebral cortex17.4
14.97
WwoxHIPHippocampal region7.04
7.03
WwoxHPFHippocampal formation11.59
12.01
WwoxHYHypothalamus5.91
4.3
WwoxLSXLateral septal complex5.87
5.13
WwoxMBMidbrain7.67
7.03
WwoxMYMedulla12.6
13.7
WwoxOLFOlfactory bulb10.36
8.55
WwoxPPons11.85
11.62
WwoxPALPallidum6.27
4.98
WwoxRHPRetrohippocampal region19.4
18.9
WwoxsAMYStriatum-like amygdalar nuclei4.45
4.34
WwoxSTRStriatum3.93
3.29
WwoxSTRdStriatum dorsal region3.25
2.65
WwoxSTRvStriatum ventral region4.31
3.21
WwoxTHThalamus8.51
6.75
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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