AutismKB 2.0

Annotation Detail for SERPINF1


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Basic Information Top
Gene Symbol:SERPINF1 ( EPC-1,PEDF )
Gene Full Name: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Band: 17p13.3
Quick LinksEntrez ID:5176; OMIM: 172860; Uniprot ID:PEDF_HUMAN; ENSEMBL ID: ENSG00000132386; HGNC ID: 8824
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst4 / 6231964
fetus89 / 564012157
neonate0 / 310970 
infant5 / 23620211
juvenile2 / 5555635
adult410 / 1939121211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma22 / 82823265
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor9 / 26384534
glioma8 / 10688374
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor21 / 96359217
lung tumor5 / 10312748
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal559 / 3360307166
ovarian tumor4 / 7668252
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer2 / 10268019
retinoblastoma58 / 463561251
skin tumor19 / 124949152
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone27 / 71655376
bone marrow4 / 4880181
brain104 / 110098994
cervix1 / 4817120
connective tissue15 / 149255100
ear1 / 1621261
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye167 / 211054791
heart16 / 89626178
intestine8 / 23447234
kidney9 / 21177742
larynx2 / 2414582
liver62 / 207743298
lung31 / 33697491
lymph2 / 4427045
lymph node3 / 9161032
mammary gland10 / 15327165
mouth5 / 6705274
muscle19 / 107715176
nerve2 / 15768126
ovary6 / 10205158
pancreas46 / 214812214
parathyroid0 / 205390 
pharynx15 / 41328362
pituitary gland0 / 165850 
placenta75 / 280825267
prostate9 / 18934547
salivary gland0 / 201550 
skin45 / 210574213
spleen8 / 53952148
stomach7 / 9661972
testis50 / 330442151
thymus6 / 8113173
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202283_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte6227.85
AdrenalCortex49.05
Adrenalgland126.9
Amygdala173.7
Appendix709.75
AtrioventricularNode384
BDCA4+_DentriticCells2435.65
Bonemarrow11.65
BronchialEpithelialCells105.2
CD105+_Endothelial15.3
CD14+_Monocytes15.4
CD19+_BCells(neg._sel.)10.05
CD33+_Myeloid10.8
CD34+12.75
CD4+_Tcells8.45
CD56+_NKCells7.5
CD71+_EarlyErythroid8.15
CD8+_Tcells8.75
CardiacMyocytes40.85
Caudatenucleus14.15
Cerebellum9.05
CerebellumPeduncles81.8
CiliaryGanglion342.25
CingulateCortex93.7
Colorectaladenocarcinoma189.4
DorsalRootGanglion150.95
FetalThyroid1138.9
Fetalbrain8.3
Fetalliver1027.65
Fetallung658.4
GlobusPallidus43
Heart712.65
Hypothalamus198.65
Kidney7.7
Leukemia_chronicMyelogenousK-562116.95
Leukemia_promyelocytic-HL-605.65
Leukemialymphoblastic(MOLT-4)7.15
Liver5399.05
Lung507.35
Lymphnode324.2
Lymphoma_burkitts(Daudi)9.2
Lymphoma_burkitts(Raji)10.35
MedullaOblongata36.75
OccipitalLobe122.3
OlfactoryBulb209.5
Ovary1572.35
Pancreas204.6
PancreaticIslet555.6
ParietalLobe66.65
Pituitary185.2
Placenta866.15
Pons39.85
PrefrontalCortex141
Prostate528.4
Salivarygland117.15
SkeletalMuscle579.05
Skin302.4
SmoothMuscle248.2
Spinalcord46.05
SubthalamicNucleus48.4
SuperiorCervicalGanglion142.15
TemporalLobe98.7
Testis1156.55
TestisGermCell2852.05
TestisIntersitial1121.1
TestisLeydigCell748.1
TestisSeminiferousTubule1509.5
Thalamus320.15
Thymus455.85
Thyroid360.9
Tongue252.95
Tonsil527.2
Trachea444.95
TrigeminalGanglion173.4
Uterus1710.6
UterusCorpus706.1
WholeBlood8.25
Wholebrain457
colon186.45
pineal_day7276.94
pineal_night9322.3
retina6193.325
small_intestine299.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16693_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.81 ± 0.73
Basal Forebrain4.84 ± 0.43
Basal Part of Pons5.96 ± 0.61
Cerebellar Cortex5.62 ± 0.94
Cerebellar Nuclei5.81 ± 0.69
Claustrum6.72 ± 0.98
Epithalamus6.13 ± 0.57
Frontal Lobe6.83 ± 0.81
Globus Pallidus4.91 ± 1.79
Hypothalamus5.99 ± 0.78
Insula6.95 ± 0.41
Limbic Lobe6.26 ± 1.41
Mesencephalon5.96 ± 0.9
Myelencephalon6.28 ± 1.14
Occipital Lobe5.08 ± 1.54
Parietal Lobe6.54 ± 0.92
Pontine Tegmentum6.35 ± 0.98
Striatum4.28 ± 1.75
Subthalamus5.99 ± 2.03
Temporal Lobe7.08 ± 0.69
Thalamus6.9 ± 0.62
White Matter4.61 ± 0.85
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Serpinf1CBCerebellum10.3
11.64
Serpinf1CTXCerebral cortex3.87
2.22
Serpinf1HIPHippocampal region7.36
6.09
Serpinf1HPFHippocampal formation7.38
5.22
Serpinf1HYHypothalamus4.08
3.18
Serpinf1LSXLateral septal complex5.72
3.28
Serpinf1MBMidbrain6.67
6.01
Serpinf1MYMedulla13
12.92
Serpinf1OLFOlfactory bulb7.22
3.93
Serpinf1PPons9.86
9.25
Serpinf1PALPallidum5.81
4.67
Serpinf1RHPRetrohippocampal region7.14
3.97
Serpinf1sAMYStriatum-like amygdalar nuclei3.54
3.08
Serpinf1STRStriatum3.28
2.48
Serpinf1STRdStriatum dorsal region2.95
2.28
Serpinf1STRvStriatum ventral region3.23
2.44
Serpinf1THThalamus8.67
6.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024774 12 400 411 DTDTGALLFIGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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