AutismKB 2.0

Annotation Detail for ZAK


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Basic Information Top
Gene Symbol:ZAK ( AZK,MLK7,MLT,MLTK,MRK,mlklak,pk )
Gene Full Name: -
Band: 2q24.2
Quick LinksEntrez ID:51776; OMIM: 609479; Uniprot ID:MLTK_HUMAN; ENSEMBL ID: ENSG00000091436; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus54 / 56401295
neonate4 / 31097128
infant0 / 236200 
juvenile6 / 55556107
adult188 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma12 / 82823144
colorectal tumor12 / 114246105
esophageal tumor2 / 17290115
gastrointestinal tumor17 / 119369142
germ cell tumor16 / 26384560
glioma7 / 10688365
head and neck tumor15 / 136302110
kidney tumor9 / 68959130
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor19 / 103127184
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal296 / 336030788
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites6 / 40015149
bladder2 / 2975767
blood6 / 12347848
bone9 / 71655125
bone marrow2 / 4880140
brain46 / 110098941
cervix3 / 4817162
connective tissue11 / 14925573
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus7 / 20209346
eye25 / 211054118
heart13 / 89626145
intestine34 / 234472145
kidney20 / 21177794
larynx2 / 2414582
liver5 / 20774324
lung29 / 33697486
lymph0 / 442700 
lymph node4 / 9161043
mammary gland10 / 15327165
mouth9 / 67052134
muscle24 / 107715222
nerve1 / 1576863
ovary5 / 10205148
pancreas3 / 21481213
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta9 / 28082532
prostate53 / 189345279
salivary gland0 / 201550 
skin11 / 21057452
spleen4 / 5395274
stomach21 / 96619217
testis19 / 33044257
thymus1 / 8113112
thyroid7 / 47473147
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord1 / 1368073
uterus35 / 232878150
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218833_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte6.15
AdrenalCortex7.75
Adrenalgland5.5
Amygdala6.45
Appendix7.05
AtrioventricularNode6.75
BDCA4+_DentriticCells6.9
Bonemarrow6.55
BronchialEpithelialCells6.4
CD105+_Endothelial7.15
CD14+_Monocytes6.9
CD19+_BCells(neg._sel.)6.9
CD33+_Myeloid8.2
CD34+9
CD4+_Tcells6.8
CD56+_NKCells7.1
CD71+_EarlyErythroid6.1
CD8+_Tcells5.8
CardiacMyocytes9.1
Caudatenucleus5.75
Cerebellum5.15
CerebellumPeduncles7.55
CiliaryGanglion6.75
CingulateCortex6.6
Colorectaladenocarcinoma6.35
DorsalRootGanglion8.5
FetalThyroid6.25
Fetalbrain6.35
Fetalliver5.55
Fetallung5
GlobusPallidus6.75
Heart9.2
Hypothalamus6.8
Kidney5.55
Leukemia_chronicMyelogenousK-5625.75
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)5.05
Liver8.65
Lung6.9
Lymphnode5.25
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)9.45
MedullaOblongata5.85
OccipitalLobe5.75
OlfactoryBulb5.1
Ovary4.6
Pancreas5.3
PancreaticIslet6.8
ParietalLobe7
Pituitary7.55
Placenta6.4
Pons6.2
PrefrontalCortex7.85
Prostate7.4
Salivarygland5.35
SkeletalMuscle10.35
Skin5.95
SmoothMuscle7.05
Spinalcord6.85
SubthalamicNucleus10.15
SuperiorCervicalGanglion9.4
TemporalLobe5.95
Testis5.55
TestisGermCell5.4
TestisIntersitial5.5
TestisLeydigCell6.5
TestisSeminiferousTubule5.5
Thalamus7.2
Thymus4.85
Thyroid7.8
Tongue8.15
Tonsil6.4
Trachea5.25
TrigeminalGanglion7.15
Uterus5.05
UterusCorpus6.35
WholeBlood7.35
Wholebrain5.15
colon6.45
pineal_day7.78
pineal_night7.68
retina7.85
small_intestine6.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8066_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.02 ± 1.16
Basal Forebrain1.52 ± 0.14
Basal Part of Pons1.31 ± 0.44
Cerebellar Cortex1.45 ± 0.64
Cerebellar Nuclei2.06 ± 0.71
Claustrum2.54 ± 0.89
Epithalamus1.96 ± 0.51
Frontal Lobe1.62 ± 0.75
Globus Pallidus2.29 ± 0.4
Hypothalamus1.55 ± 0.63
Insula1.52 ± 0.52
Limbic Lobe1.63 ± 0.7
Mesencephalon1.85 ± 0.74
Myelencephalon1.8 ± 0.69
Occipital Lobe1.74 ± 0.72
Parietal Lobe1.83 ± 1
Pontine Tegmentum1.77 ± 0.81
Striatum1.91 ± 0.69
Subthalamus1.81 ± 0.7
Temporal Lobe1.58 ± 0.66
Thalamus1.75 ± 0.65
White Matter1.8 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
B230120H23RikCBCerebellum28.85
26.55
B230120H23RikCTXCerebral cortex27.46
19.79
B230120H23RikHIPHippocampal region20.02
11.1
B230120H23RikHPFHippocampal formation31.57
23.6
B230120H23RikHYHypothalamus62.92
42.65
B230120H23RikLSXLateral septal complex17.77
10.23
B230120H23RikMBMidbrain33.75
24.73
B230120H23RikMYMedulla71.83
70.76
B230120H23RikOLFOlfactory bulb67.79
48.26
B230120H23RikPPons52.55
44
B230120H23RikPALPallidum18.9
13.79
B230120H23RikRHPRetrohippocampal region46.68
36.45
B230120H23RiksAMYStriatum-like amygdalar nuclei38.84
26.52
B230120H23RikSTRStriatum10.94
6.9
B230120H23RikSTRdStriatum dorsal region3.04
1.81
B230120H23RikSTRvStriatum ventral region20.19
11.52
B230120H23RikTHThalamus20.9
13.55
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096866 15 234 248 SFAELLHQCWEADAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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