AutismKB 2.0

Annotation Detail for TUBA8


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Basic Information Top
Gene Symbol:TUBA8 ( TUBAL2 )
Gene Full Name: tubulin, alpha 8
Band: 22q11.21
Quick LinksEntrez ID:51807; OMIM: 605742; Uniprot ID:TBA8_HUMAN; ENSEMBL ID: ENSG00000183785; HGNC ID: 12410
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal51 / 336030715
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain24 / 110098921
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart3 / 8962633
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle25 / 107715232
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220069_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.45
Adipocyte4.45
AdrenalCortex4.95
Adrenalgland3.95
Amygdala4.7
Appendix4.75
AtrioventricularNode3.7
BDCA4+_DentriticCells4.8
Bonemarrow4.6
BronchialEpithelialCells4.45
CD105+_Endothelial4.9
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.7
CD34+5.65
CD4+_Tcells4.85
CD56+_NKCells5.3
CD71+_EarlyErythroid4.35
CD8+_Tcells4.3
CardiacMyocytes6.3
Caudatenucleus4.1
Cerebellum3.75
CerebellumPeduncles5.25
CiliaryGanglion3.35
CingulateCortex4.9
Colorectaladenocarcinoma4.6
DorsalRootGanglion3.6
FetalThyroid4.45
Fetalbrain4.45
Fetalliver4
Fetallung3.65
GlobusPallidus3.45
Heart6.2
Hypothalamus4.9
Kidney3.85
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.6
Liver6.15
Lung5
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.95
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4.1
OccipitalLobe4.05
OlfactoryBulb3.6
Ovary3.1
Pancreas3.7
PancreaticIslet4.85
ParietalLobe4.95
Pituitary5.3
Placenta4.65
Pons4.4
PrefrontalCortex5.6
Prostate5.25
Salivarygland3.7
SkeletalMuscle5.8
Skin3.65
SmoothMuscle5.15
Spinalcord4.9
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.45
TemporalLobe4.2
Testis3.9
TestisGermCell3.75
TestisIntersitial3.8
TestisLeydigCell4.55
TestisSeminiferousTubule3.9
Thalamus4.65
Thymus3.55
Thyroid5.6
Tongue4.6
Tonsil4.45
Trachea3.8
TrigeminalGanglion4.85
Uterus3.65
UterusCorpus4.2
WholeBlood4.9
Wholebrain3.75
colon4.6
pineal_day5.64
pineal_night5.52
retina5.5
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4727_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.67 ± 0.45
Basal Forebrain5.88 ± 0.23
Basal Part of Pons7.22 ± 0.3
Cerebellar Cortex6.96 ± 0.36
Cerebellar Nuclei6.51 ± 0.47
Claustrum6.91 ± 0.41
Epithalamus5.11 ± 0.9
Frontal Lobe6.86 ± 0.5
Globus Pallidus5.05 ± 0.42
Hypothalamus6.22 ± 0.58
Insula6.71 ± 0.36
Limbic Lobe6.8 ± 0.57
Mesencephalon6.4 ± 0.53
Myelencephalon6.42 ± 0.74
Occipital Lobe6.01 ± 0.67
Parietal Lobe6.62 ± 0.48
Pontine Tegmentum6.44 ± 0.52
Striatum5.47 ± 0.46
Subthalamus6.51 ± 0.26
Temporal Lobe6.67 ± 0.43
Thalamus6.44 ± 0.45
White Matter4.29 ± 0.67
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000326 20 337 356 AFVHWYVGEGMEEGEFSEAR Peptide Atlas
TBA8_HUMAN_105 16 105 120 GHYTVGKESIDLVLDR PRIDE
TBA8_HUMAN_214 15 214 228 RNLDIERPTYTNLNR PRIDE
TBA8_HUMAN_215 14 215 228 NLDIERPTYTNLNR PRIDE
TBA8_HUMAN_229 14 229 242 LISQIVSSITASLR PRIDE
TBA8_HUMAN_243 21 243 263 FDGALNVDLTEFQTNLVPYPR PRIDE
TBA8_HUMAN_264 16 264 279 IHFPLVTYAPIISAEK PRIDE
TBA8_HUMAN_326 10 326 335 DVNVAIAAIK PRIDE
TBA8_HUMAN_338 14 338 351 RTIQFVDWCPTGFK PRIDE
TBA8_HUMAN_339 13 339 351 TIQFVDWCPTGFK PRIDE
TBA8_HUMAN_352 18 352 369 VGINYQPPTVVPGGDLAK PRIDE
TBA8_HUMAN_373 17 373 389 AVCMLSNTTAIAEAWAR PRIDE
TBA8_HUMAN_390 11 390 400 LDHKFDLMYAK PRIDE
TBA8_HUMAN_390 12 390 401 LDHKFDLMYAKR PRIDE
TBA8_HUMAN_402 20 402 421 AFVHWYVGEGMEEGEFSEAR PRIDE
TBA8_HUMAN_64 15 64 78 AVMIDLEPTVVDEVR PRIDE
TBA8_HUMAN_84 12 84 95 QLFHPEQLITGK PRIDE
TBA8_HUMAN_84 21 84 104 QLFHPEQLITGKEDAANNYAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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