AutismKB 2.0

Annotation Detail for PFKFB3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PFKFB3 ( FLJ37326,IPFK2,PFK2 )
Gene Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Band: 10p15.1
Quick LinksEntrez ID:5209; OMIM: 605319; Uniprot ID:F263_HUMAN; ENSEMBL ID: ENSG00000170525; HGNC ID: 8874
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus24 / 56401242
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor17 / 26384564
glioma11 / 106883102
head and neck tumor10 / 13630273
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia9 / 9725092
normal330 / 336030798
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder4 / 29757134
blood8 / 12347864
bone6 / 7165583
bone marrow0 / 488010 
brain228 / 1100989207
cervix0 / 481710 
connective tissue13 / 14925587
ear1 / 1621261
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine8 / 23447234
kidney15 / 21177770
larynx1 / 2414541
liver1 / 2077434
lung14 / 33697441
lymph0 / 442700 
lymph node11 / 91610120
mammary gland7 / 15327145
mouth9 / 67052134
muscle9 / 10771583
nerve0 / 157680 
ovary3 / 10205129
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta9 / 28082532
prostate3 / 18934515
salivary gland0 / 201550 
skin10 / 21057447
spleen4 / 5395274
stomach2 / 9661920
testis31 / 33044293
thymus7 / 8113186
thyroid1 / 4747321
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord1 / 1368073
uterus19 / 23287881
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202464_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts36.9
Adipocyte154.95
AdrenalCortex42.45
Adrenalgland36.1
Amygdala162.25
Appendix39.15
AtrioventricularNode28.55
BDCA4+_DentriticCells116.3
Bonemarrow97.1
BronchialEpithelialCells59.15
CD105+_Endothelial39
CD14+_Monocytes97
CD19+_BCells(neg._sel.)43.45
CD33+_Myeloid163
CD34+57.6
CD4+_Tcells43.35
CD56+_NKCells53.2
CD71+_EarlyErythroid16.1
CD8+_Tcells31.8
CardiacMyocytes55.1
Caudatenucleus62.9
Cerebellum47.7
CerebellumPeduncles42.6
CiliaryGanglion39.85
CingulateCortex56.7
Colorectaladenocarcinoma24.25
DorsalRootGanglion31.8
FetalThyroid37.75
Fetalbrain153.6
Fetalliver17.15
Fetallung61.15
GlobusPallidus32.25
Heart44
Hypothalamus269.55
Kidney66.85
Leukemia_chronicMyelogenousK-56215.6
Leukemia_promyelocytic-HL-6029.45
Leukemialymphoblastic(MOLT-4)27.8
Liver39.75
Lung217.6
Lymphnode32.85
Lymphoma_burkitts(Daudi)38.6
Lymphoma_burkitts(Raji)56.05
MedullaOblongata48.65
OccipitalLobe68.2
OlfactoryBulb121.15
Ovary22.55
Pancreas44.45
PancreaticIslet70.3
ParietalLobe50.9
Pituitary46.35
Placenta31.35
Pons37.3
PrefrontalCortex181.25
Prostate47.4
Salivarygland33
SkeletalMuscle617.3
Skin53.4
SmoothMuscle81.1
Spinalcord455.5
SubthalamicNucleus54.65
SuperiorCervicalGanglion53.95
TemporalLobe53.3
Testis54.25
TestisGermCell30.05
TestisIntersitial28.9
TestisLeydigCell26.1
TestisSeminiferousTubule28.95
Thalamus72.1
Thymus38.65
Thyroid34
Tongue37.45
Tonsil45.2
Trachea33.25
TrigeminalGanglion43.75
Uterus31.45
UterusCorpus29.95
WholeBlood122.7
Wholebrain137.35
colon86
pineal_day57.02
pineal_night43
retina674.975
small_intestine93.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P95755
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.37 ± 0.48
Basal Forebrain6.63 ± 0.39
Basal Part of Pons6.03 ± 0.48
Cerebellar Cortex5.9 ± 0.26
Cerebellar Nuclei6.57 ± 0.36
Claustrum6.68 ± 0.45
Epithalamus7 ± 0.41
Frontal Lobe6.22 ± 0.5
Globus Pallidus7.84 ± 0.38
Hypothalamus6.56 ± 0.79
Insula6.05 ± 0.56
Limbic Lobe6.24 ± 0.58
Mesencephalon6.54 ± 0.49
Myelencephalon6.44 ± 0.51
Occipital Lobe6.3 ± 0.48
Parietal Lobe6.42 ± 0.56
Pontine Tegmentum6.46 ± 0.52
Striatum6.65 ± 0.54
Subthalamus5.98 ± 0.64
Temporal Lobe6.29 ± 0.51
Thalamus6.48 ± 0.34
White Matter7.3 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pfkfb3CBCerebellum26.11
57.95
Pfkfb3CTXCerebral cortex53.36
43.48
Pfkfb3HIPHippocampal region29.26
44.35
Pfkfb3HPFHippocampal formation24.71
30.34
Pfkfb3HYHypothalamus19.1
16.35
Pfkfb3LSXLateral septal complex28.52
22.85
Pfkfb3MBMidbrain33.14
35.81
Pfkfb3MYMedulla54.89
70.42
Pfkfb3OLFOlfactory bulb44.61
36.21
Pfkfb3PPons39.6
45.75
Pfkfb3PALPallidum27.31
29.68
Pfkfb3RHPRetrohippocampal region19.37
15.86
Pfkfb3sAMYStriatum-like amygdalar nuclei20.57
16.37
Pfkfb3STRStriatum44.22
33.28
Pfkfb3STRdStriatum dorsal region53.96
41.14
Pfkfb3STRvStriatum ventral region28.59
20.13
Pfkfb3THThalamus13.08
15.16
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved