AutismKB 2.0

Annotation Detail for PGD


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Basic Information Top
Gene Symbol:PGD ( 6PGD )
Gene Full Name: phosphogluconate dehydrogenase
Band: 1p36.22
Quick LinksEntrez ID:5226; OMIM: 172200; Uniprot ID:6PGD_HUMAN; ENSEMBL ID: ENSG00000142657; HGNC ID: 8891
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body17 / 70761240
blastocyst23 / 62319369
fetus75 / 564012132
neonate13 / 31097418
infant8 / 23620338
juvenile16 / 55556287
adult323 / 1939121166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma4 / 17475228
breast (mammary gland) tumor27 / 94178286
cervical tumor11 / 34366320
chondrosarcoma20 / 82823241
colorectal tumor15 / 114246131
esophageal tumor21 / 172901214
gastrointestinal tumor34 / 119369284
germ cell tumor57 / 263845216
glioma34 / 106883318
head and neck tumor28 / 136302205
kidney tumor13 / 68959188
leukemia41 / 95842427
liver tumor23 / 96359238
lung tumor55 / 103127533
lymphoma21 / 71755292
non-neoplasia15 / 97250154
normal541 / 3360307160
ovarian tumor20 / 76682260
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS38 / 125680302
prostate cancer17 / 102680165
retinoblastoma29 / 46356625
skin tumor32 / 124949256
soft tissue/muscle tissue tumor44 / 125191351
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland3 / 3319790
ascites13 / 40015324
bladder5 / 29757168
blood55 / 123478445
bone16 / 71655223
bone marrow18 / 48801368
brain182 / 1100989165
cervix13 / 48171269
connective tissue17 / 149255113
ear0 / 162120 
embryonic tissue57 / 215722264
esophagus23 / 202091138
eye58 / 211054274
heart11 / 89626122
intestine41 / 234472174
kidney35 / 211777165
larynx5 / 24145207
liver34 / 207743163
lung91 / 336974270
lymph14 / 44270316
lymph node14 / 91610152
mammary gland36 / 153271234
mouth23 / 67052343
muscle24 / 107715222
nerve1 / 1576863
ovary30 / 102051293
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx10 / 41328241
pituitary gland1 / 1658560
placenta51 / 280825181
prostate23 / 189345121
salivary gland2 / 2015599
skin44 / 210574208
spleen6 / 53952111
stomach15 / 96619155
testis56 / 330442169
thymus14 / 81131172
thyroid6 / 47473126
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord2 / 13680146
uterus44 / 232878188
vascular17 / 51780328
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201118_at
Cell line Expression level Expression bar
721_B_lymphoblasts459.65
Adipocyte579.75
AdrenalCortex13.2
Adrenalgland11.7
Amygdala13.9
Appendix16.45
AtrioventricularNode8.1
BDCA4+_DentriticCells271.95
Bonemarrow334.55
BronchialEpithelialCells331.35
CD105+_Endothelial46.95
CD14+_Monocytes633.75
CD19+_BCells(neg._sel.)16
CD33+_Myeloid359.2
CD34+66.65
CD4+_Tcells19
CD56+_NKCells23.2
CD71+_EarlyErythroid12.8
CD8+_Tcells18.15
CardiacMyocytes73
Caudatenucleus12.45
Cerebellum22.5
CerebellumPeduncles14
CiliaryGanglion7.75
CingulateCortex13.35
Colorectaladenocarcinoma135.75
DorsalRootGanglion8.65
FetalThyroid19.15
Fetalbrain53.2
Fetalliver29.6
Fetallung52.95
GlobusPallidus8.5
Heart21.85
Hypothalamus20.15
Kidney13
Leukemia_chronicMyelogenousK-562292.3
Leukemia_promyelocytic-HL-60620.9
Leukemialymphoblastic(MOLT-4)126.05
Liver53.95
Lung81
Lymphnode16.3
Lymphoma_burkitts(Daudi)99.35
Lymphoma_burkitts(Raji)215.65
MedullaOblongata12.6
OccipitalLobe14.85
OlfactoryBulb9.6
Ovary9.05
Pancreas10.5
PancreaticIslet17.35
ParietalLobe14.2
Pituitary15.7
Placenta37.5
Pons13.45
PrefrontalCortex22.05
Prostate18.85
Salivarygland13.35
SkeletalMuscle15.4
Skin9
SmoothMuscle361.45
Spinalcord13.6
SubthalamicNucleus11.6
SuperiorCervicalGanglion11.85
TemporalLobe15.85
Testis63.95
TestisGermCell62.05
TestisIntersitial25.05
TestisLeydigCell22.75
TestisSeminiferousTubule20.25
Thalamus24.15
Thymus56.4
Thyroid81.2
Tongue32.4
Tonsil36.1
Trachea61
TrigeminalGanglion13.1
Uterus11.2
UterusCorpus11.85
WholeBlood692.15
Wholebrain30.9
colon17.55
pineal_day72.98
pineal_night102.8
retina81.425
small_intestine71.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7864_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.25 ± 0.84
Basal Forebrain5.52 ± 0.26
Basal Part of Pons5.94 ± 0.22
Cerebellar Cortex5.51 ± 0.43
Cerebellar Nuclei5.29 ± 0.48
Claustrum4.75 ± 0.66
Epithalamus5.47 ± 0.39
Frontal Lobe5.54 ± 0.45
Globus Pallidus5.05 ± 0.32
Hypothalamus5.72 ± 0.32
Insula5.35 ± 0.39
Limbic Lobe5.26 ± 0.48
Mesencephalon5.23 ± 0.52
Myelencephalon5.32 ± 0.55
Occipital Lobe4.97 ± 0.48
Parietal Lobe5.36 ± 0.49
Pontine Tegmentum5.26 ± 0.45
Striatum4.77 ± 0.43
Subthalamus4.97 ± 0.31
Temporal Lobe5.42 ± 0.47
Thalamus5.32 ± 0.46
White Matter5.04 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PgdCBCerebellum1.5
1.77
PgdCTXCerebral cortex0.49
0.74
PgdHIPHippocampal region1.74
1.4
PgdHPFHippocampal formation1.49
1.13
PgdHYHypothalamus2.54
2.14
PgdLSXLateral septal complex0.08
0.07
PgdMBMidbrain1.4
1.86
PgdMYMedulla8.85
12.17
PgdOLFOlfactory bulb5.63
4.73
PgdPPons3.62
5.96
PgdPALPallidum3.14
3.36
PgdRHPRetrohippocampal region0.85
0.63
PgdsAMYStriatum-like amygdalar nuclei0.39
0.4
PgdSTRStriatum0.67
0.6
PgdSTRdStriatum dorsal region0.46
0.47
PgdSTRvStriatum ventral region1.88
1.4
PgdTHThalamus0.55
0.49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
6PGD_HUMAN_0 0 0 0 GILFVGSGVSGGEEGAR PRIDE
6PGD_HUMAN_0 0 0 0 IKDAFDRNPELQNLLLDDFFK PRIDE
6PGD_HUMAN_0 0 0 0 LVPLLDTGDIIIDGGNSEYR PRIDE
6PGD_HUMAN_0 0 0 0 TVSKVDDFLANEAK PRIDE
6PGD_HUMAN_119 17 119 135 GILFVGSGVSGGEEGAR PRIDE
6PGD_HUMAN_136 11 136 146 YGPSLMPGGNK PRIDE
6PGD_HUMAN_154 9 154 162 TIFQGIAAK PRIDE
6PGD_HUMAN_163 21 163 183 VGTGEPCCDWVGDEGAGHFVK PRIDE
6PGD_HUMAN_184 22 184 205 MVHNGIEYGDMQLICEAYHLMK PRIDE
6PGD_HUMAN_261 27 261 287 GTGKWTAISALEYGVPVTLIGEAVFAR PRIDE
6PGD_HUMAN_265 23 265 287 WTAISALEYGVPVTLIGEAVFAR PRIDE
6PGD_HUMAN_288 9 288 296 CLSSLKDER PRIDE
6PGD_HUMAN_289 9 289 297 CLSSLKDER PRIDE
6PGD_HUMAN_317 8 317 324 SFLEDIRK PRIDE
6PGD_HUMAN_331 12 331 342 IISYAQGFMLLR PRIDE
6PGD_HUMAN_34 14 34 47 TVSKVDDFLANEAK PRIDE
6PGD_HUMAN_375 21 375 395 IKDAFDRNPELQNLLLDDFFK PRIDE
6PGD_HUMAN_377 19 377 395 DAFDRNPELQNLLLDDFFK PRIDE
6PGD_HUMAN_382 14 382 395 NPELQNLLLDDFFK PRIDE
6PGD_HUMAN_434 13 434 446 HEMLPASLIQAQR PRIDE
6PGD_HUMAN_76 11 76 86 AGQAVDDFIEK PRIDE
6PGD_HUMAN_87 20 87 106 LVPLLDTGDIIIDGGNSEYR PRIDE
PAp00001186 9 289 297 CLSSLKDER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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