AutismKB 2.0

Annotation Detail for PHB


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Basic Information Top
Gene Symbol:PHB ( PHB1 )
Gene Full Name: prohibitin
Band: 17q21.33
Quick LinksEntrez ID:5245; OMIM: 176705; Uniprot ID:PHB_HUMAN; ENSEMBL ID: ENSG00000167085; HGNC ID: 8912
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst17 / 62319272
fetus66 / 564012117
neonate5 / 31097160
infant27 / 236201143
juvenile32 / 55556575
adult360 / 1939121185
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma7 / 17475400
breast (mammary gland) tumor38 / 94178403
cervical tumor11 / 34366320
chondrosarcoma33 / 82823398
colorectal tumor40 / 114246350
esophageal tumor3 / 17290173
gastrointestinal tumor43 / 119369360
germ cell tumor46 / 263845174
glioma20 / 106883187
head and neck tumor12 / 13630288
kidney tumor18 / 68959261
leukemia15 / 95842156
liver tumor84 / 96359871
lung tumor32 / 103127310
lymphoma33 / 71755459
non-neoplasia16 / 97250164
normal488 / 3360307145
ovarian tumor16 / 76682208
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS83 / 125680660
prostate cancer32 / 102680311
retinoblastoma22 / 46356474
skin tumor71 / 124949568
soft tissue/muscle tissue tumor36 / 125191287
uterine tumor20 / 90257221
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland12 / 33197361
ascites15 / 40015374
bladder5 / 29757168
blood16 / 123478129
bone26 / 71655362
bone marrow3 / 4880161
brain177 / 1100989160
cervix20 / 48171415
connective tissue25 / 149255167
ear0 / 162120 
embryonic tissue44 / 215722203
esophagus4 / 20209197
eye45 / 211054213
heart14 / 89626156
intestine74 / 234472315
kidney47 / 211777221
larynx1 / 2414541
liver116 / 207743558
lung71 / 336974210
lymph23 / 44270519
lymph node17 / 91610185
mammary gland42 / 153271274
mouth2 / 6705229
muscle13 / 107715120
nerve2 / 15768126
ovary20 / 102051195
pancreas49 / 214812228
parathyroid2 / 2053997
pharynx7 / 41328169
pituitary gland1 / 1658560
placenta39 / 280825138
prostate52 / 189345274
salivary gland5 / 20155248
skin84 / 210574398
spleen5 / 5395292
stomach31 / 96619320
testis43 / 330442130
thymus7 / 8113186
thyroid11 / 47473231
tonsil3 / 16999176
trachea1 / 5241319
umbilical cord3 / 13680219
uterus58 / 232878249
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200659_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts141.8
Adipocyte61.8
AdrenalCortex22.6
Adrenalgland20.55
Amygdala26.2
Appendix30.3
AtrioventricularNode10.4
BDCA4+_DentriticCells133.35
Bonemarrow46.9
BronchialEpithelialCells68.4
CD105+_Endothelial49.15
CD14+_Monocytes48.8
CD19+_BCells(neg._sel.)36.1
CD33+_Myeloid22.5
CD34+126.75
CD4+_Tcells62.3
CD56+_NKCells92.7
CD71+_EarlyErythroid23.9
CD8+_Tcells52.65
CardiacMyocytes46.8
Caudatenucleus24.55
Cerebellum27
CerebellumPeduncles41.35
CiliaryGanglion9.05
CingulateCortex15.1
Colorectaladenocarcinoma105.45
DorsalRootGanglion12.25
FetalThyroid62.5
Fetalbrain27.35
Fetalliver38.05
Fetallung29.4
GlobusPallidus13.2
Heart154.15
Hypothalamus28.8
Kidney134.85
Leukemia_chronicMyelogenousK-56242.6
Leukemia_promyelocytic-HL-6039.8
Leukemialymphoblastic(MOLT-4)34.4
Liver277.4
Lung163.3
Lymphnode21.4
Lymphoma_burkitts(Daudi)64.6
Lymphoma_burkitts(Raji)126.1
MedullaOblongata22.45
OccipitalLobe32.2
OlfactoryBulb32.9
Ovary23.5
Pancreas44.65
PancreaticIslet51.05
ParietalLobe32.95
Pituitary56.7
Placenta55.75
Pons27.25
PrefrontalCortex30
Prostate154
Salivarygland50.45
SkeletalMuscle66.2
Skin10.75
SmoothMuscle44.7
Spinalcord21.7
SubthalamicNucleus11.15
SuperiorCervicalGanglion34.55
TemporalLobe35.5
Testis41.9
TestisGermCell38.4
TestisIntersitial18.8
TestisLeydigCell26
TestisSeminiferousTubule37.4
Thalamus23.05
Thymus38.05
Thyroid123.4
Tongue36.5
Tonsil38.5
Trachea50.9
TrigeminalGanglion13.2
Uterus58
UterusCorpus33.95
WholeBlood34.9
Wholebrain53.65
colon161.6
pineal_day42.04
pineal_night51.8
retina123.8
small_intestine116
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P262355
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.22 ± 0.28
Basal Forebrain7.31 ± 0.28
Basal Part of Pons7.46 ± 0.25
Cerebellar Cortex7.43 ± 0.25
Cerebellar Nuclei7.38 ± 0.21
Claustrum7.13 ± 0.2
Epithalamus7.31 ± 0.12
Frontal Lobe7.51 ± 0.24
Globus Pallidus7.51 ± 0.17
Hypothalamus7.62 ± 0.19
Insula7.44 ± 0.16
Limbic Lobe7.42 ± 0.25
Mesencephalon7.43 ± 0.24
Myelencephalon7.38 ± 0.27
Occipital Lobe7.11 ± 0.22
Parietal Lobe7.39 ± 0.25
Pontine Tegmentum7.38 ± 0.26
Striatum7.23 ± 0.2
Subthalamus7.32 ± 0.37
Temporal Lobe7.45 ± 0.27
Thalamus7.35 ± 0.19
White Matter7.83 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PhbCBCerebellum28.98
61.31
PhbCTXCerebral cortex67.21
58.49
PhbHIPHippocampal region33.79
58.93
PhbHPFHippocampal formation41.62
53.42
PhbHYHypothalamus57.22
56.57
PhbLSXLateral septal complex19.32
15.77
PhbMBMidbrain57.53
64.99
PhbMYMedulla69.22
96.73
PhbOLFOlfactory bulb57.97
52.1
PhbPPons59.99
81.05
PhbPALPallidum58.4
67.44
PhbRHPRetrohippocampal region53.25
46.7
PhbsAMYStriatum-like amygdalar nuclei39.31
33.4
PhbSTRStriatum31.27
27.36
PhbSTRdStriatum dorsal region29.2
25.68
PhbSTRvStriatum ventral region39.45
33.89
PhbTHThalamus47.52
52.95
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000146 20 220 239 AAELIANSLATAGDGLIELR Peptide Atlas
PHB_HUMAN_0 0 0 0 DLQNVNITLR PRIDE
PHB_HUMAN_0 0 0 0 FDAGELITQR PRIDE
PHB_HUMAN_0 0 0 0 IFTSIGEDYDER PRIDE
PHB_HUMAN_0 0 0 0 KLEAAEDIAYQLSR PRIDE
PHB_HUMAN_0 0 0 0 NITYLPAGQSVLLQLPQ PRIDE
PHB_HUMAN_105 12 105 116 IFTSIGEDYDER PRIDE
PHB_HUMAN_11 24 11 34 FGLALAVAGGVVNSALYNVDAGHR PRIDE
PHB_HUMAN_117 11 117 127 VLPSITTEILK PRIDE
PHB_HUMAN_118 11 118 128 VLPSITTEILK PRIDE
PHB_HUMAN_133 10 133 142 FDAGELITQR PRIDE
PHB_HUMAN_149 9 149 157 QVSDDLTER PRIDE
PHB_HUMAN_157 20 157 176 AATFGLILDDVSLTHLTFGK PRIDE
PHB_HUMAN_157 29 157 185 AATFGLILDDVSLTHLTFGKEFTEAVEAK PRIDE
PHB_HUMAN_219 20 219 238 AAELIANSLATAGDGLIELR PRIDE
PHB_HUMAN_239 14 239 252 KLEAAEDIAYQLSR PRIDE
PHB_HUMAN_255 17 255 271 NITYLPAGQSVLLQLPQ PRIDE
PHB_HUMAN_43 27 43 69 GVQDIVVGEGTHFLIPWVQKPIIFDCR PRIDE
PHB_HUMAN_74 19 74 92 NVPVITGSKDLQNVNITLR PRIDE
PHB_HUMAN_83 10 83 92 DLQNVNITLR PRIDE
PHB_HUMAN_93 12 93 104 ILFRPVASQLPR PRIDE
PHB_HUMAN_98 8 98 105 PVASQLPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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