AutismKB 2.0

Annotation Detail for SERPINE2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SERPINE2 ( DKFZp686A13110,GDN,PI-7,PI7,PN-1,PN1,PNI )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Band: 2q36.1
Quick LinksEntrez ID:5270; OMIM: 177010; Uniprot ID:GDN_HUMAN; ENSEMBL ID: ENSG00000135919; HGNC ID: 8951
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst10 / 62319160
fetus37 / 56401265
neonate28 / 31097900
infant8 / 23620338
juvenile12 / 55556215
adult401 / 1939121206
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus3 / 5640125
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult9 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor2 / 3436658
chondrosarcoma34 / 82823410
colorectal tumor12 / 114246105
esophageal tumor2 / 17290115
gastrointestinal tumor2 / 11936916
germ cell tumor100 / 263845379
glioma13 / 106883121
head and neck tumor9 / 13630266
kidney tumor14 / 68959203
leukemia5 / 9584252
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia62 / 97250637
normal708 / 3360307210
ovarian tumor9 / 76682117
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor69 / 124949552
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal20 / 33603075
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder3 / 29757100
blood6 / 12347848
bone29 / 71655404
bone marrow10 / 48801204
brain240 / 1100989217
cervix4 / 4817183
connective tissue138 / 149255924
ear3 / 16212185
embryonic tissue35 / 215722162
esophagus4 / 20209197
eye5 / 21105423
heart6 / 8962666
intestine20 / 23447285
kidney30 / 211777141
larynx2 / 2414582
liver7 / 20774333
lung21 / 33697462
lymph0 / 442700 
lymph node1 / 9161010
mammary gland12 / 15327178
mouth4 / 6705259
muscle2 / 10771518
nerve1 / 1576863
ovary9 / 10205188
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta183 / 280825651
prostate6 / 18934531
salivary gland0 / 201550 
skin128 / 210574607
spleen5 / 5395292
stomach3 / 9661931
testis49 / 330442148
thymus7 / 8113186
thyroid7 / 47473147
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus21 / 23287890
vascular45 / 51780869
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone6 / 7165583
bone marrow0 / 488010 
brain3 / 11009892
cervix1 / 4817120
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212190_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte870.5
AdrenalCortex16.9
Adrenalgland13.85
Amygdala734.35
Appendix26.7
AtrioventricularNode35.4
BDCA4+_DentriticCells5.75
Bonemarrow16.7
BronchialEpithelialCells1308.65
CD105+_Endothelial73.4
CD14+_Monocytes6.7
CD19+_BCells(neg._sel.)7.05
CD33+_Myeloid8.65
CD34+305.4
CD4+_Tcells13.1
CD56+_NKCells17.75
CD71+_EarlyErythroid12
CD8+_Tcells10.9
CardiacMyocytes3219.1
Caudatenucleus310.55
Cerebellum306.6
CerebellumPeduncles264.85
CiliaryGanglion41.5
CingulateCortex350.9
Colorectaladenocarcinoma22.55
DorsalRootGanglion86.85
FetalThyroid74.35
Fetalbrain272.35
Fetalliver19.3
Fetallung122.75
GlobusPallidus113.75
Heart14.85
Hypothalamus695.1
Kidney59.85
Leukemia_chronicMyelogenousK-56215.15
Leukemia_promyelocytic-HL-608.45
Leukemialymphoblastic(MOLT-4)49.7
Liver13.6
Lung16.95
Lymphnode67.55
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)8.25
MedullaOblongata199.15
OccipitalLobe514.15
OlfactoryBulb523.15
Ovary41.9
Pancreas262.15
PancreaticIslet114.2
ParietalLobe292.4
Pituitary28.75
Placenta4202.8
Pons284.45
PrefrontalCortex821.85
Prostate22.4
Salivarygland17.55
SkeletalMuscle19.15
Skin14.9
SmoothMuscle2824.15
Spinalcord710.55
SubthalamicNucleus262.95
SuperiorCervicalGanglion83.85
TemporalLobe196.25
Testis248.25
TestisGermCell335.35
TestisIntersitial148
TestisLeydigCell90.75
TestisSeminiferousTubule159.45
Thalamus309.4
Thymus23.8
Thyroid88.15
Tongue15.65
Tonsil100.25
Trachea42.6
TrigeminalGanglion77.35
Uterus30.4
UterusCorpus86.3
WholeBlood6.55
Wholebrain886.3
colon17.1
pineal_day137.52
pineal_night71.28
retina281.325
small_intestine210.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14298_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.14 ± 0.46
Basal Forebrain6.11 ± 0.31
Basal Part of Pons5.07 ± 0.36
Cerebellar Cortex5.28 ± 0.48
Cerebellar Nuclei5.49 ± 0.6
Claustrum6.66 ± 0.71
Epithalamus6.04 ± 0.51
Frontal Lobe5.87 ± 0.6
Globus Pallidus6.84 ± 0.32
Hypothalamus6.18 ± 0.39
Insula5.77 ± 0.57
Limbic Lobe5.51 ± 0.62
Mesencephalon6.16 ± 0.51
Myelencephalon5.94 ± 0.6
Occipital Lobe6.12 ± 0.54
Parietal Lobe5.94 ± 0.61
Pontine Tegmentum6.07 ± 0.41
Striatum5.83 ± 0.59
Subthalamus6.06 ± 0.34
Temporal Lobe5.71 ± 0.58
Thalamus6.27 ± 0.52
White Matter4.88 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Serpine2CBCerebellum47.02
76.98
Serpine2CTXCerebral cortex80.45
86.36
Serpine2HIPHippocampal region55.27
74.05
Serpine2HPFHippocampal formation66.73
82.47
Serpine2HYHypothalamus90.08
93.95
Serpine2LSXLateral septal complex100
100
Serpine2MBMidbrain96.29
100
Serpine2MYMedulla74.52
85.87
Serpine2OLFOlfactory bulb92.8
96.8
Serpine2PPons82.59
90.47
Serpine2PALPallidum93.79
100
Serpine2RHPRetrohippocampal region85.04
92.37
Serpine2sAMYStriatum-like amygdalar nuclei100
100
Serpine2STRStriatum100
100
Serpine2STRdStriatum dorsal region100
100
Serpine2STRvStriatum ventral region100
100
Serpine2THThalamus87.33
92.45
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GDN_HUMAN_162 18 162 179 DMIDNLLSPDLIDGVLTR PRIDE
GDN_HUMAN_180 10 180 189 LVLVNAVYFK PRIDE
GDN_HUMAN_295 26 295 320 FTAVAQTDLKEPLKVLGITDMFDSSK PRIDE
PAp00094287 12 45 56 SRPHDNIVISPH Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved