AutismKB 2.0

Annotation Detail for SERPINB9


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Basic Information Top
Gene Symbol:SERPINB9 ( CAP-3,CAP3,PI9 )
Gene Full Name: serpin peptidase inhibitor, clade B (ovalbumin), member 9
Band: 6p25.2
Quick LinksEntrez ID:5272; OMIM: 601799; Uniprot ID:SPB9_HUMAN; ENSEMBL ID: ENSG00000170542; HGNC ID: 8955
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst5 / 6231980
fetus6 / 56401210
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor13 / 26384549
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia2 / 9725020
normal97 / 336030728
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow2 / 4880140
brain7 / 11009896
cervix0 / 481710 
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung4 / 33697411
lymph5 / 44270112
lymph node12 / 91610130
mammary gland3 / 15327119
mouth3 / 6705244
muscle3 / 10771527
nerve0 / 157680 
ovary3 / 10205129
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta31 / 280825110
prostate0 / 1893450 
salivary gland3 / 20155148
skin4 / 21057418
spleen3 / 5395255
stomach2 / 9661920
testis7 / 33044221
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209723_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.4
Adipocyte3.6
AdrenalCortex3.8
Adrenalgland3.45
Amygdala4
Appendix3.75
AtrioventricularNode2.75
BDCA4+_DentriticCells11.05
Bonemarrow3.5
BronchialEpithelialCells3.45
CD105+_Endothelial3.9
CD14+_Monocytes53
CD19+_BCells(neg._sel.)80.7
CD33+_Myeloid47.45
CD34+11.8
CD4+_Tcells72.45
CD56+_NKCells116.8
CD71+_EarlyErythroid3.4
CD8+_Tcells59.3
CardiacMyocytes4.7
Caudatenucleus3.25
Cerebellum3
CerebellumPeduncles4.15
CiliaryGanglion2.7
CingulateCortex3.8
Colorectaladenocarcinoma5.05
DorsalRootGanglion10.5
FetalThyroid3.6
Fetalbrain3.5
Fetalliver3.05
Fetallung5.3
GlobusPallidus2.65
Heart4.6
Hypothalamus4.1
Kidney3
Leukemia_chronicMyelogenousK-5623.4
Leukemia_promyelocytic-HL-6013.1
Leukemialymphoblastic(MOLT-4)2.8
Liver4.75
Lung6.1
Lymphnode39.45
Lymphoma_burkitts(Daudi)119.2
Lymphoma_burkitts(Raji)4.95
MedullaOblongata3.45
OccipitalLobe3.3
OlfactoryBulb6.55
Ovary2.45
Pancreas2.9
PancreaticIslet3.9
ParietalLobe3.8
Pituitary4.35
Placenta110.15
Pons3.5
PrefrontalCortex4.8
Prostate4.45
Salivarygland3.05
SkeletalMuscle4.15
Skin2.8
SmoothMuscle4.3
Spinalcord4.15
SubthalamicNucleus3.3
SuperiorCervicalGanglion4.1
TemporalLobe3.4
Testis3.35
TestisGermCell15.35
TestisIntersitial3.2
TestisLeydigCell3.55
TestisSeminiferousTubule3.25
Thalamus3.7
Thymus14.8
Thyroid4.65
Tongue3.6
Tonsil20.8
Trachea3.05
TrigeminalGanglion3.65
Uterus3.15
UterusCorpus3.25
WholeBlood51.15
Wholebrain4.25
colon3.75
pineal_day7.52
pineal_night10.62
retina8.4
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P38323
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.97 ± 0.49
Basal Forebrain5.58 ± 0.27
Basal Part of Pons6.01 ± 0.18
Cerebellar Cortex6.11 ± 0.28
Cerebellar Nuclei6.74 ± 0.2
Claustrum5.9 ± 0.56
Epithalamus6.1 ± 0.24
Frontal Lobe5.94 ± 0.41
Globus Pallidus6.63 ± 0.28
Hypothalamus6 ± 0.37
Insula5.88 ± 0.32
Limbic Lobe6.01 ± 0.46
Mesencephalon5.96 ± 0.48
Myelencephalon6.03 ± 0.39
Occipital Lobe6.4 ± 0.4
Parietal Lobe6.13 ± 0.38
Pontine Tegmentum6.02 ± 0.45
Striatum5.75 ± 0.43
Subthalamus6.45 ± 0.34
Temporal Lobe5.86 ± 0.36
Thalamus5.86 ± 0.36
White Matter6.83 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Serpinb9CBCerebellum13.55
17.12
Serpinb9CTXCerebral cortex1.34
1.49
Serpinb9HIPHippocampal region2.54
2.46
Serpinb9HPFHippocampal formation2.55
2.28
Serpinb9HYHypothalamus1.03
0.88
Serpinb9LSXLateral septal complex0.24
0.25
Serpinb9MBMidbrain1.31
1.58
Serpinb9MYMedulla4.08
4.52
Serpinb9OLFOlfactory bulb6.09
5.76
Serpinb9PPons0.83
0.95
Serpinb9PALPallidum0.32
0.47
Serpinb9RHPRetrohippocampal region2.66
2.1
Serpinb9sAMYStriatum-like amygdalar nuclei0.7
0.64
Serpinb9STRStriatum0.99
1.03
Serpinb9STRdStriatum dorsal region0.86
0.98
Serpinb9STRvStriatum ventral region1.64
1.55
Serpinb9THThalamus1.25
1.35
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00033794 12 349 360 FCADHPFLFFIR Peptide Atlas
SPB9_HUMAN_1 14 1 14 METLSNASGTFAIR PRIDE
SPB9_HUMAN_105 12 105 116 ESCLQFYHAELK PRIDE
SPB9_HUMAN_143 15 143 157 IEELLPGSSIDAETR PRIDE
SPB9_HUMAN_158 10 158 167 LVLVNAIYFK PRIDE
SPB9_HUMAN_186 19 186 204 INQEEQRPVQMMYQEATFK PRIDE
SPB9_HUMAN_213 10 213 222 AQLLELPYAR PRIDE
SPB9_HUMAN_223 21 223 243 KELSLLVLLPDDGVELSTVEK PRIDE
SPB9_HUMAN_261 10 261 270 STEVEVLLPK PRIDE
SPB9_HUMAN_273 12 273 284 LQEDYDMESVLR PRIDE
SPB9_HUMAN_285 12 285 296 HLGIVDAFQQGK PRIDE
SPB9_HUMAN_348 12 348 359 FCADHPFLFFIR PRIDE
SPB9_HUMAN_47 21 47 67 GNTATQMAQALSLNTEEDIHR PRIDE
SPB9_HUMAN_68 11 68 78 AFQSLLTEVNK PRIDE
SPB9_HUMAN_96 9 96 104 TCQFLSTFK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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