Annotation Detail for PIK3CA
Basic Information Top
| Gene Symbol: | PIK3CA ( MGC142161,MGC142163,PI3K,p110-alpha ) |
|---|---|
| Gene Full Name: | phosphoinositide-3-kinase, catalytic, alpha polypeptide |
| Band: | 3q26.32 |
| Quick Links | Entrez ID:5290; OMIM: 171834; Uniprot ID:PK3CA_HUMAN; ENSEMBL ID: ENSG00000121879; HGNC ID: 8975 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.553498
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 4 / 62319 | 64 |  |
| fetus | 12 / 564012 | 21 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 36 / 1939121 | 18 | |
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 18 / 564012 | 31 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 29 / 1939121 | 14 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 2 / 17475 | 114 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 2 / 34366 | 58 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 |  |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 1 / 96359 | 10 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 77 / 3360307 | 22 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 5 / 125191 | 39 | |
| uterine tumor | 1 / 90257 | 11 | |
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 2 / 263845 | 7 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 51 / 3360307 | 15 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 2 / 29757 | 67 | |
| blood | 2 / 123478 | 16 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 10 / 1100989 | 9 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 7 / 215722 | 32 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 2 / 211054 | 9 | |
| heart | 4 / 89626 | 44 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 3 / 211777 | 14 | |
| larynx | 0 / 24145 | 0 | |
| liver | 4 / 207743 | 19 | |
| lung | 2 / 336974 | 5 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 7 / 91610 | 76 | |
| mammary gland | 4 / 153271 | 26 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 6 / 107715 | 55 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 7 / 280825 | 24 | |
| prostate | 5 / 189345 | 26 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 7 / 210574 | 33 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 9 / 330442 | 27 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 7 / 51780 | 135 | |
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 1 / 123478 | 8 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 5 / 1100989 | 4 | |
| cervix | 4 / 48171 | 83 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 2 / 215722 | 9 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 5 / 211054 | 23 | |
| heart | 1 / 89626 | 11 | |
| intestine | 4 / 234472 | 17 | |
| kidney | 2 / 211777 | 9 | |
| larynx | 0 / 24145 | 0 | |
| liver | 2 / 207743 | 9 | |
| lung | 2 / 336974 | 5 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 7 / 280825 | 24 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 4 / 232878 | 17 | |
| vascular | 6 / 51780 | 115 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204369_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 40.4 | |
| Adipocyte | 8.25 | |
| AdrenalCortex | 7.95 | |
| Adrenalgland | 5.9 | |
| Amygdala | 6.95 | |
| Appendix | 7.55 | |
| AtrioventricularNode | 7.15 | |
| BDCA4+_DentriticCells | 7.55 | |
| Bonemarrow | 7.1 | |
| BronchialEpithelialCells | 6.75 | |
| CD105+_Endothelial | 6.55 | |
| CD14+_Monocytes | 11.05 | |
| CD19+_BCells(neg._sel.) | 51.5 | |
| CD33+_Myeloid | 27.1 | |
| CD34+ | 10.9 | |
| CD4+_Tcells | 39.7 | |
| CD56+_NKCells | 29.4 | |
| CD71+_EarlyErythroid | 6.5 | |
| CD8+_Tcells | 60.7 | |
| CardiacMyocytes | 10.2 | |
| Caudatenucleus | 5.9 | |
| Cerebellum | 5.45 | |
| CerebellumPeduncles | 8.5 | |
| CiliaryGanglion | 5.45 | |
| CingulateCortex | 7.15 | |
| Colorectaladenocarcinoma | 6.85 | |
| DorsalRootGanglion | 5.65 | |
| FetalThyroid | 6.9 | |
| Fetalbrain | 8.15 | |
| Fetalliver | 6.1 | |
| Fetallung | 5.55 | |
| GlobusPallidus | 5.25 | |
| Heart | 9.55 | |
| Hypothalamus | 7.2 | |
| Kidney | 5.85 | |
| Leukemia_chronicMyelogenousK-562 | 6.35 | |
| Leukemia_promyelocytic-HL-60 | 6.45 | |
| Leukemialymphoblastic(MOLT-4) | 5.45 | |
| Liver | 9.6 | |
| Lung | 7.05 | |
| Lymphnode | 5.9 | |
| Lymphoma_burkitts(Daudi) | 13.35 | |
| Lymphoma_burkitts(Raji) | 10.15 | |
| MedullaOblongata | 6.1 | |
| OccipitalLobe | 7.55 | |
| OlfactoryBulb | 5.5 | |
| Ovary | 4.75 | |
| Pancreas | 5.55 | |
| PancreaticIslet | 7.4 | |
| ParietalLobe | 7.65 | |
| Pituitary | 8 | |
| Placenta | 6.4 | |
| Pons | 6.85 | |
| PrefrontalCortex | 21.65 | |
| Prostate | 7.75 | |
| Salivarygland | 5.75 | |
| SkeletalMuscle | 9.25 | |
| Skin | 6.55 | |
| SmoothMuscle | 7.9 | |
| Spinalcord | 7.05 | |
| SubthalamicNucleus | 6.9 | |
| SuperiorCervicalGanglion | 9.7 | |
| TemporalLobe | 6.45 | |
| Testis | 5.6 | |
| TestisGermCell | 5.9 | |
| TestisIntersitial | 5.8 | |
| TestisLeydigCell | 6.9 | |
| TestisSeminiferousTubule | 5.95 | |
| Thalamus | 7 | |
| Thymus | 5.25 | |
| Thyroid | 7.85 | |
| Tongue | 7.1 | |
| Tonsil | 6.85 | |
| Trachea | 5.8 | |
| TrigeminalGanglion | 7.6 | |
| Uterus | 10.75 | |
| UterusCorpus | 6.6 | |
| WholeBlood | 10.05 | |
| Wholebrain | 5.4 | |
| colon | 8.05 | |
| pineal_day | 12.5 | |
| pineal_night | 8.96 | |
| retina | 8.05 | |
| small_intestine | 6.3 | |
- Probe name: CUST_15807_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.67 ± 0.19 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.63 ± 0.2 | |
| Basal Part of Pons | 7.71 ± 0.3 | |
| Cerebellar Cortex | 7.65 ± 0.23 | |
| Cerebellar Nuclei | 7.8 ± 0.29 | |
| Claustrum | 7.9 ± 0.33 | |
| Epithalamus | 7.48 ± 0.32 | |
| Frontal Lobe | 7.6 ± 0.26 | |
| Globus Pallidus | 7.67 ± 0.13 | |
| Hypothalamus | 7.59 ± 0.19 | |
| Insula | 7.47 ± 0.25 | |
| Limbic Lobe | 7.59 ± 0.31 | |
| Mesencephalon | 7.63 ± 0.3 | |
| Myelencephalon | 7.59 ± 0.26 | |
| Occipital Lobe | 7.93 ± 0.18 | |
| Parietal Lobe | 7.77 ± 0.36 | |
| Pontine Tegmentum | 7.71 ± 0.25 | |
| Striatum | 7.42 ± 0.2 | |
| Subthalamus | 7.76 ± 0.56 | |
| Temporal Lobe | 7.57 ± 0.26 | |
| Thalamus | 7.64 ± 0.23 | |
| White Matter | 7.49 ± 0.35 | |
Mouse Brain ISH 