AutismKB 2.0

Annotation Detail for PIK3R2


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Basic Information Top
Gene Symbol:PIK3R2 ( P85B,p85,p85-BETA )
Gene Full Name: phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Band: 19p13.11
Quick LinksEntrez ID:5296; OMIM: 603157; Uniprot ID:P85B_HUMAN; ENSEMBL ID: ENSG00000105647; HGNC ID: 8980
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor20 / 26384575
glioma30 / 106883280
head and neck tumor10 / 13630273
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal89 / 336030726
ovarian tumor11 / 76682143
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS29 / 125680230
prostate cancer11 / 102680107
retinoblastoma5 / 46356107
skin tumor18 / 124949144
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain75 / 110098968
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye9 / 21105442
heart0 / 896260 
intestine21 / 23447289
kidney10 / 21177747
larynx4 / 24145165
liver2 / 2077439
lung14 / 33697441
lymph1 / 4427022
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle5 / 10771546
nerve0 / 157680 
ovary27 / 102051264
pancreas21 / 21481297
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate11 / 18934558
salivary gland6 / 20155297
skin22 / 210574104
spleen2 / 5395237
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207105_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte8.2
AdrenalCortex8.7
Adrenalgland6.7
Amygdala7.25
Appendix7.95
AtrioventricularNode10.5
BDCA4+_DentriticCells7.15
Bonemarrow7.1
BronchialEpithelialCells6.45
CD105+_Endothelial6.65
CD14+_Monocytes7.4
CD19+_BCells(neg._sel.)6.85
CD33+_Myeloid8.25
CD34+8.2
CD4+_Tcells6.85
CD56+_NKCells7.6
CD71+_EarlyErythroid10.7
CD8+_Tcells5.95
CardiacMyocytes8.35
Caudatenucleus8.15
Cerebellum5.85
CerebellumPeduncles9.55
CiliaryGanglion6.1
CingulateCortex8.25
Colorectaladenocarcinoma6.5
DorsalRootGanglion6.2
FetalThyroid7.7
Fetalbrain25.45
Fetalliver6.85
Fetallung5.85
GlobusPallidus8.45
Heart8.5
Hypothalamus7.5
Kidney6.35
Leukemia_chronicMyelogenousK-5626.55
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)7.05
Liver10.35
Lung7.45
Lymphnode6.85
Lymphoma_burkitts(Daudi)9.3
Lymphoma_burkitts(Raji)10
MedullaOblongata7.85
OccipitalLobe6.95
OlfactoryBulb5.55
Ovary5.15
Pancreas5.95
PancreaticIslet7.45
ParietalLobe8.65
Pituitary10.25
Placenta6.75
Pons12.4
PrefrontalCortex8.3
Prostate8.4
Salivarygland5.8
SkeletalMuscle10.45
Skin6.4
SmoothMuscle7.95
Spinalcord10.65
SubthalamicNucleus14.65
SuperiorCervicalGanglion9.25
TemporalLobe10.8
Testis6.05
TestisGermCell5.6
TestisIntersitial5.9
TestisLeydigCell7.2
TestisSeminiferousTubule7.15
Thalamus7.4
Thymus5.15
Thyroid8.05
Tongue8.2
Tonsil7.15
Trachea5.95
TrigeminalGanglion8.5
Uterus5.4
UterusCorpus7.05
WholeBlood7.5
Wholebrain6
colon6.8
pineal_day8.24
pineal_night8.22
retina8.3
small_intestine6.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P142361
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.47 ± 0.48
Basal Forebrain5.7 ± 0.17
Basal Part of Pons6.01 ± 0.34
Cerebellar Cortex5.48 ± 0.35
Cerebellar Nuclei5.22 ± 0.42
Claustrum6.81 ± 0.67
Epithalamus5.33 ± 0.47
Frontal Lobe5.64 ± 0.48
Globus Pallidus5.16 ± 0.36
Hypothalamus5.25 ± 0.51
Insula5.84 ± 0.54
Limbic Lobe6.41 ± 0.55
Mesencephalon5.62 ± 0.54
Myelencephalon5.81 ± 0.59
Occipital Lobe6.22 ± 0.56
Parietal Lobe5.92 ± 0.62
Pontine Tegmentum5.75 ± 0.54
Striatum6.57 ± 0.44
Subthalamus5.15 ± 0.6
Temporal Lobe5.96 ± 0.44
Thalamus5.61 ± 0.46
White Matter4.99 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pik3r2CBCerebellum100
100
Pik3r2CTXCerebral cortex100
100
Pik3r2HIPHippocampal region100
100
Pik3r2HPFHippocampal formation100
100
Pik3r2HYHypothalamus100
100
Pik3r2LSXLateral septal complex100
100
Pik3r2MBMidbrain100
100
Pik3r2MYMedulla97.37
100
Pik3r2OLFOlfactory bulb100
100
Pik3r2PPons100
100
Pik3r2PALPallidum100
100
Pik3r2RHPRetrohippocampal region100
100
Pik3r2sAMYStriatum-like amygdalar nuclei100
100
Pik3r2STRStriatum100
100
Pik3r2STRdStriatum dorsal region100
100
Pik3r2STRvStriatum ventral region100
100
Pik3r2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00078529 18 673 690 TATGFGFAEPYNLYGSLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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