AutismKB 2.0

Annotation Detail for PLAT


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Basic Information Top
Gene Symbol:PLAT ( DKFZp686I03148,T-PA,TPA )
Gene Full Name: plasminogen activator, tissue
Band: 8p11.21
Quick LinksEntrez ID:5327; OMIM: 173370; Uniprot ID:TPA_HUMAN; ENSEMBL ID: ENSG00000104368; HGNC ID: 9051
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst4 / 6231964
fetus53 / 56401293
neonate10 / 31097321
infant0 / 236200 
juvenile5 / 5555689
adult276 / 1939121142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma24 / 82823289
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor142 / 263845538
glioma12 / 106883112
head and neck tumor16 / 136302117
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor24 / 96359249
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia15 / 97250154
normal495 / 3360307147
ovarian tumor21 / 76682273
pancreatic tumor39 / 104616372
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor99 / 124949792
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland7 / 33197210
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone8 / 71655111
bone marrow1 / 4880120
brain98 / 110098989
cervix1 / 4817120
connective tissue13 / 14925587
ear1 / 1621261
embryonic tissue16 / 21572274
esophagus1 / 2020949
eye8 / 21105437
heart11 / 89626122
intestine46 / 234472196
kidney62 / 211777292
larynx3 / 24145124
liver27 / 207743129
lung53 / 336974157
lymph1 / 4427022
lymph node0 / 916100 
mammary gland16 / 153271104
mouth12 / 67052178
muscle1 / 1077159
nerve0 / 157680 
ovary26 / 102051254
pancreas46 / 214812214
parathyroid15 / 20539730
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta29 / 280825103
prostate26 / 189345137
salivary gland0 / 201550 
skin156 / 210574740
spleen0 / 539520 
stomach8 / 9661982
testis70 / 330442211
thymus10 / 81131123
thyroid4 / 4747384
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus33 / 232878141
vascular120 / 517802317
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201860_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.3
Adipocyte10.65
AdrenalCortex81.5
Adrenalgland193.9
Amygdala11.75
Appendix141.1
AtrioventricularNode11.6
BDCA4+_DentriticCells8.2
Bonemarrow10.3
BronchialEpithelialCells11.7
CD105+_Endothelial8.35
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)8.7
CD33+_Myeloid10.7
CD34+10.25
CD4+_Tcells8.5
CD56+_NKCells9.45
CD71+_EarlyErythroid8.3
CD8+_Tcells7.55
CardiacMyocytes408
Caudatenucleus12.9
Cerebellum16.95
CerebellumPeduncles19.25
CiliaryGanglion44.35
CingulateCortex11.95
Colorectaladenocarcinoma9.8
DorsalRootGanglion35.3
FetalThyroid18.65
Fetalbrain10.25
Fetalliver8.45
Fetallung210.85
GlobusPallidus7.2
Heart13.95
Hypothalamus16.25
Kidney113.35
Leukemia_chronicMyelogenousK-5627.95
Leukemia_promyelocytic-HL-607.5
Leukemialymphoblastic(MOLT-4)6.55
Liver13.05
Lung154.55
Lymphnode32.65
Lymphoma_burkitts(Daudi)12.25
Lymphoma_burkitts(Raji)13.7
MedullaOblongata9.95
OccipitalLobe8.85
OlfactoryBulb125.35
Ovary18.65
Pancreas11.6
PancreaticIslet14.4
ParietalLobe10.95
Pituitary12.85
Placenta27.9
Pons10
PrefrontalCortex17.4
Prostate188.9
Salivarygland8.6
SkeletalMuscle12.05
Skin9.05
SmoothMuscle42.25
Spinalcord18.35
SubthalamicNucleus9.4
SuperiorCervicalGanglion21.2
TemporalLobe9.5
Testis88.6
TestisGermCell46.6
TestisIntersitial17.15
TestisLeydigCell14.6
TestisSeminiferousTubule9.3
Thalamus9.9
Thymus20.9
Thyroid95.4
Tongue10.25
Tonsil9.65
Trachea55.95
TrigeminalGanglion11.4
Uterus171.05
UterusCorpus97.05
WholeBlood9.75
Wholebrain15.1
colon197.15
pineal_day22.3
pineal_night57.02
retina436.4
small_intestine482.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15195_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.42 ± 1.03
Basal Forebrain2.21 ± 0.49
Basal Part of Pons2.24 ± 0.58
Cerebellar Cortex2.6 ± 0.57
Cerebellar Nuclei2.7 ± 0.8
Claustrum2.68 ± 0.71
Epithalamus2.38 ± 0.71
Frontal Lobe2.21 ± 0.68
Globus Pallidus3.34 ± 0.82
Hypothalamus2.36 ± 0.38
Insula2.37 ± 0.38
Limbic Lobe2.22 ± 0.61
Mesencephalon2.5 ± 0.72
Myelencephalon2.48 ± 0.71
Occipital Lobe2.79 ± 0.71
Parietal Lobe2.36 ± 0.71
Pontine Tegmentum2.41 ± 0.75
Striatum2.67 ± 0.78
Subthalamus2.7 ± 0.86
Temporal Lobe2.31 ± 0.74
Thalamus2.65 ± 0.68
White Matter3.13 ± 0.63
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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