AutismKB 2.0

Annotation Detail for PLCB2


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Basic Information Top
Gene Symbol:PLCB2 ( FLJ38135 )
Gene Full Name: phospholipase C, beta 2
Band: 15q15.1
Quick LinksEntrez ID:5330; OMIM: 604114; Uniprot ID:PLCB2_HUMAN; ENSEMBL ID: ENSG00000137841; HGNC ID: 9055
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia26 / 95842271
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal87 / 336030725
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood27 / 123478218
bone1 / 7165513
bone marrow13 / 48801266
brain28 / 110098925
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine5 / 23447221
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung6 / 33697417
lymph0 / 442700 
lymph node11 / 91610120
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary5 / 10205148
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen6 / 53952111
stomach0 / 966190 
testis3 / 3304429
thymus5 / 8113161
thyroid0 / 474730 
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204046_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.7
Adipocyte4.1
AdrenalCortex4.2
Adrenalgland3.45
Amygdala4.4
Appendix4.1
AtrioventricularNode3.05
BDCA4+_DentriticCells16
Bonemarrow4.1
BronchialEpithelialCells4.05
CD105+_Endothelial4.25
CD14+_Monocytes57.75
CD19+_BCells(neg._sel.)6.25
CD33+_Myeloid58.3
CD34+21.25
CD4+_Tcells33.85
CD56+_NKCells30.35
CD71+_EarlyErythroid3.85
CD8+_Tcells24.85
CardiacMyocytes5
Caudatenucleus3.7
Cerebellum3.35
CerebellumPeduncles4.65
CiliaryGanglion2.85
CingulateCortex4.2
Colorectaladenocarcinoma4.15
DorsalRootGanglion3.1
FetalThyroid4
Fetalbrain4.1
Fetalliver3.6
Fetallung4.1
GlobusPallidus3.05
Heart5.25
Hypothalamus4.55
Kidney3.3
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.45
Liver6.15
Lung7.85
Lymphnode9.1
Lymphoma_burkitts(Daudi)5.2
Lymphoma_burkitts(Raji)5.7
MedullaOblongata3.8
OccipitalLobe4.1
OlfactoryBulb3.3
Ovary2.75
Pancreas3.55
PancreaticIslet5.75
ParietalLobe4.25
Pituitary5.35
Placenta5.95
Pons3.9
PrefrontalCortex5.2
Prostate4.9
Salivarygland3.3
SkeletalMuscle4.55
Skin3.1
SmoothMuscle4.7
Spinalcord4.45
SubthalamicNucleus3.65
SuperiorCervicalGanglion4.55
TemporalLobe3.75
Testis3.55
TestisGermCell3.45
TestisIntersitial3.4
TestisLeydigCell4.05
TestisSeminiferousTubule3.45
Thalamus4.15
Thymus3.35
Thyroid5.25
Tongue4
Tonsil4.35
Trachea3.5
TrigeminalGanglion3.95
Uterus3.45
UterusCorpus3.65
WholeBlood9
Wholebrain3.55
colon4.15
pineal_day5.16
pineal_night5.04
retina5.025
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11282_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.33 ± 0.5
Basal Forebrain6 ± 0.26
Basal Part of Pons5.12 ± 0.58
Cerebellar Cortex4.49 ± 0.42
Cerebellar Nuclei5.38 ± 0.47
Claustrum6.15 ± 0.46
Epithalamus5.31 ± 0.69
Frontal Lobe5.15 ± 0.64
Globus Pallidus6.25 ± 0.31
Hypothalamus5.43 ± 0.35
Insula5.3 ± 0.58
Limbic Lobe5.45 ± 0.68
Mesencephalon5.4 ± 1.05
Myelencephalon5.34 ± 0.76
Occipital Lobe4.61 ± 0.61
Parietal Lobe5.12 ± 0.83
Pontine Tegmentum5.18 ± 0.56
Striatum6.58 ± 0.49
Subthalamus5.17 ± 0.62
Temporal Lobe5.37 ± 0.64
Thalamus4.76 ± 0.62
White Matter6.56 ± 0.74
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plcb2CBCerebellum2.33
3.68
Plcb2CTXCerebral cortex1.01
1.31
Plcb2HIPHippocampal region1.62
2.53
Plcb2HPFHippocampal formation1.3
1.89
Plcb2HYHypothalamus0.17
0.34
Plcb2LSXLateral septal complex0
0
Plcb2MBMidbrain0.35
0.68
Plcb2MYMedulla0.8
1.13
Plcb2OLFOlfactory bulb3.06
2.67
Plcb2PPons0.34
0.66
Plcb2PALPallidum0.22
0.31
Plcb2RHPRetrohippocampal region0.64
0.79
Plcb2sAMYStriatum-like amygdalar nuclei0.17
0.16
Plcb2STRStriatum0.15
0.2
Plcb2STRdStriatum dorsal region0.14
0.22
Plcb2STRvStriatum ventral region0.28
0.28
Plcb2THThalamus0.65
0.96
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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