AutismKB 2.0

Annotation Detail for PLCG1


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Basic Information Top
Gene Symbol:PLCG1 ( NCKAP3,PLC-II,PLC1,PLC148,PLCgamma1 )
Gene Full Name: phospholipase C, gamma 1
Band: 20q12
Quick LinksEntrez ID:5335; OMIM: 172420; Uniprot ID:PLCG1_HUMAN; ENSEMBL ID: ENSG00000124181; HGNC ID: 9065
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst11 / 62319176
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult136 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor14 / 114246122
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor6 / 26384522
glioma9 / 10688384
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia9 / 9584293
liver tumor1 / 9635910
lung tumor12 / 103127116
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal161 / 336030747
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer7 / 10268068
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone2 / 7165527
bone marrow2 / 4880140
brain67 / 110098960
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus1 / 2020949
eye13 / 21105461
heart2 / 8962622
intestine22 / 23447293
kidney8 / 21177737
larynx0 / 241450 
liver1 / 2077434
lung19 / 33697456
lymph1 / 4427022
lymph node8 / 9161087
mammary gland11 / 15327171
mouth3 / 6705244
muscle7 / 10771564
nerve2 / 15768126
ovary7 / 10205168
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate8 / 18934542
salivary gland0 / 201550 
skin11 / 21057452
spleen0 / 539520 
stomach6 / 9661962
testis13 / 33044239
thymus16 / 81131197
thyroid12 / 47473252
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216551_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.6
Adipocyte17.15
AdrenalCortex15.25
Adrenalgland12.85
Amygdala13.15
Appendix13.35
AtrioventricularNode10.15
BDCA4+_DentriticCells8.95
Bonemarrow17.15
BronchialEpithelialCells14.5
CD105+_Endothelial10.35
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)8.6
CD33+_Myeloid9.9
CD34+7.8
CD4+_Tcells23.55
CD56+_NKCells11.7
CD71+_EarlyErythroid12.5
CD8+_Tcells14.2
CardiacMyocytes20.65
Caudatenucleus11.75
Cerebellum24.7
CerebellumPeduncles18.25
CiliaryGanglion9.45
CingulateCortex15.3
Colorectaladenocarcinoma16.4
DorsalRootGanglion11.1
FetalThyroid15.95
Fetalbrain13.7
Fetalliver15.65
Fetallung12.65
GlobusPallidus10
Heart20.15
Hypothalamus13.65
Kidney14.35
Leukemia_chronicMyelogenousK-56213.1
Leukemia_promyelocytic-HL-6012.25
Leukemialymphoblastic(MOLT-4)17.15
Liver29.55
Lung19.6
Lymphnode12.35
Lymphoma_burkitts(Daudi)17.5
Lymphoma_burkitts(Raji)21.25
MedullaOblongata12.55
OccipitalLobe11.9
OlfactoryBulb11.25
Ovary8.95
Pancreas11.4
PancreaticIslet13.5
ParietalLobe15.3
Pituitary25.4
Placenta14.6
Pons14.5
PrefrontalCortex13.15
Prostate15.4
Salivarygland10.9
SkeletalMuscle16.55
Skin10.15
SmoothMuscle16.15
Spinalcord17.05
SubthalamicNucleus9.45
SuperiorCervicalGanglion15.15
TemporalLobe11
Testis18.65
TestisGermCell12.35
TestisIntersitial11.25
TestisLeydigCell15.4
TestisSeminiferousTubule13.45
Thalamus13.7
Thymus17.35
Thyroid20.3
Tongue16.6
Tonsil13.9
Trachea13.15
TrigeminalGanglion17.65
Uterus10.65
UterusCorpus11.7
WholeBlood15.1
Wholebrain16.2
colon12.45
pineal_day12.54
pineal_night13.04
retina17.95
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14539_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.71
Basal Forebrain4.19 ± 0.6
Basal Part of Pons4.05 ± 0.57
Cerebellar Cortex4.64 ± 0.35
Cerebellar Nuclei3.95 ± 0.59
Claustrum4.63 ± 0.68
Epithalamus4.16 ± 0.36
Frontal Lobe4.01 ± 0.53
Globus Pallidus4.12 ± 0.68
Hypothalamus3.79 ± 0.57
Insula4.06 ± 0.91
Limbic Lobe4.16 ± 0.65
Mesencephalon4.36 ± 0.67
Myelencephalon4.2 ± 0.59
Occipital Lobe4.46 ± 0.49
Parietal Lobe4.21 ± 0.56
Pontine Tegmentum4.27 ± 0.66
Striatum4.01 ± 0.88
Subthalamus3.94 ± 0.21
Temporal Lobe4.24 ± 0.55
Thalamus4.22 ± 0.59
White Matter5.11 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plcg1CBCerebellum42.83
53.49
Plcg1CTXCerebral cortex100
84.24
Plcg1HIPHippocampal region64.28
97.88
Plcg1HPFHippocampal formation73.63
88.44
Plcg1HYHypothalamus44.95
33.82
Plcg1LSXLateral septal complex69.7
48.96
Plcg1MBMidbrain56.17
49.35
Plcg1MYMedulla56
54.69
Plcg1OLFOlfactory bulb86.32
75.74
Plcg1PPons47.85
44.95
Plcg1PALPallidum60.68
54.61
Plcg1RHPRetrohippocampal region92.78
77.26
Plcg1sAMYStriatum-like amygdalar nuclei93.36
71.17
Plcg1STRStriatum79.05
60.11
Plcg1STRdStriatum dorsal region79.06
61.5
Plcg1STRvStriatum ventral region77.1
54.93
Plcg1THThalamus57.31
48.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00034397 17 874 890 GVLDVPACQIAIRPEGK Peptide Atlas
PLCG1_HUMAN_179 9 179 187 NMLSQVNYR PRIDE
PLCG1_HUMAN_227 13 227 239 TMDLPFLEASTLR PRIDE
PLCG1_HUMAN_962 13 962 974 PVPFDEEKIGTER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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