AutismKB 2.0

Annotation Detail for CLIC5


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Basic Information Top
Gene Symbol:CLIC5 ( CLIC5B,FLJ90663,MST130,MSTP130,dJ447E21.4 )
Gene Full Name: chloride intracellular channel 5
Band: 6p21.1
Quick LinksEntrez ID:53405; OMIM: 607293; Uniprot ID:CLIC5_HUMAN; ENSEMBL ID: ENSG00000112782; HGNC ID: 13517
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal116 / 336030734
ovarian tumor10 / 76682130
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye8 / 21105437
heart6 / 8962666
intestine12 / 23447251
kidney21 / 21177799
larynx1 / 2414541
liver1 / 2077434
lung5 / 33697414
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth0 / 670520 
muscle10 / 10771592
nerve0 / 157680 
ovary10 / 10205197
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta34 / 280825121
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219866_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.45
Adipocyte25.4
AdrenalCortex31.6
Adrenalgland25.55
Amygdala26
Appendix24.45
AtrioventricularNode22.75
BDCA4+_DentriticCells16.75
Bonemarrow31.95
BronchialEpithelialCells21.95
CD105+_Endothelial30
CD14+_Monocytes22.7
CD19+_BCells(neg._sel.)25.85
CD33+_Myeloid30.25
CD34+26.4
CD4+_Tcells39
CD56+_NKCells21.8
CD71+_EarlyErythroid26.3
CD8+_Tcells27
CardiacMyocytes37
Caudatenucleus21.05
Cerebellum21.55
CerebellumPeduncles41.9
CiliaryGanglion32.35
CingulateCortex25.6
Colorectaladenocarcinoma33.15
DorsalRootGanglion23.7
FetalThyroid28.9
Fetalbrain23.55
Fetalliver17.6
Fetallung37.4
GlobusPallidus20.65
Heart190.35
Hypothalamus24.4
Kidney124.3
Leukemia_chronicMyelogenousK-56222.25
Leukemia_promyelocytic-HL-6024.75
Leukemialymphoblastic(MOLT-4)22.45
Liver36.8
Lung728.4
Lymphnode21.1
Lymphoma_burkitts(Daudi)35.2
Lymphoma_burkitts(Raji)39.7
MedullaOblongata20.95
OccipitalLobe26
OlfactoryBulb20.05
Ovary20
Pancreas25.9
PancreaticIslet27.75
ParietalLobe30.45
Pituitary31.8
Placenta138.5
Pons29.1
PrefrontalCortex29.3
Prostate23.4
Salivarygland22.4
SkeletalMuscle427.9
Skin24.75
SmoothMuscle25
Spinalcord26.3
SubthalamicNucleus18.1
SuperiorCervicalGanglion51.85
TemporalLobe24.45
Testis21.15
TestisGermCell20.6
TestisIntersitial18.85
TestisLeydigCell24.95
TestisSeminiferousTubule24.6
Thalamus27.1
Thymus19.15
Thyroid53.6
Tongue55.35
Tonsil27.3
Trachea25.1
TrigeminalGanglion53.1
Uterus18.55
UterusCorpus26.15
WholeBlood26.4
Wholebrain26.35
colon105.1
pineal_day25.78
pineal_night28.66
retina38.15
small_intestine65.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3134_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.46 ± 1.05
Basal Forebrain2.37 ± 0.68
Basal Part of Pons2.21 ± 0.54
Cerebellar Cortex2.08 ± 0.75
Cerebellar Nuclei2.95 ± 1.52
Claustrum3.1 ± 0.69
Epithalamus2.13 ± 0.64
Frontal Lobe2.26 ± 0.74
Globus Pallidus2.75 ± 0.41
Hypothalamus2.51 ± 0.71
Insula1.89 ± 0.55
Limbic Lobe2.3 ± 0.64
Mesencephalon2.53 ± 0.88
Myelencephalon2.43 ± 0.81
Occipital Lobe2.72 ± 0.79
Parietal Lobe2.34 ± 0.91
Pontine Tegmentum2.33 ± 0.7
Striatum2.84 ± 0.85
Subthalamus2.38 ± 0.85
Temporal Lobe2.22 ± 0.81
Thalamus2.48 ± 0.72
White Matter2.51 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Clic5CBCerebellum2.6
2.79
Clic5CTXCerebral cortex3.45
2.46
Clic5HIPHippocampal region2.04
2.01
Clic5HPFHippocampal formation3.53
2.93
Clic5HYHypothalamus0.71
0.49
Clic5LSXLateral septal complex0.67
0.7
Clic5MBMidbrain1.25
1.39
Clic5MYMedulla5.93
5.57
Clic5OLFOlfactory bulb5.2
4.03
Clic5PPons3.51
3
Clic5PALPallidum1.76
1.31
Clic5RHPRetrohippocampal region6.61
4.51
Clic5sAMYStriatum-like amygdalar nuclei1.61
1.02
Clic5STRStriatum3.01
2.51
Clic5STRdStriatum dorsal region3.99
3.5
Clic5STRvStriatum ventral region1.07
0.67
Clic5THThalamus1.46
0.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CLIC5_HUMAN_0 0 0 0 KFLDGDELTLADCNLLPK PRIDE
CLIC5_HUMAN_332 18 332 349 KFLDGDELTLADCNLLPK PRIDE
PAp00002476 17 334 350 FLDGDELTLADCNLLPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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