AutismKB 2.0

Annotation Detail for PLP1


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Basic Information Top
Gene Symbol:PLP1 ( HLD1,MMPL,PLP,PLP/DM20,PMD,SPG2 )
Gene Full Name: proteolipid protein 1
Band: Xq22.2
Quick LinksEntrez ID:5354; OMIM: 300401; Uniprot ID:MYPR_HUMAN; ENSEMBL ID: ENSG00000123560; HGNC ID: 9086
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst11 / 62319176
fetus52 / 56401292
neonate0 / 310970 
infant4 / 23620169
juvenile16 / 55556287
adult441 / 1939121227
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma1 / 1747557
breast (mammary gland) tumor11 / 94178116
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma40 / 106883374
head and neck tumor0 / 1363020 
kidney tumor445 / 689596453
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia174 / 972501789
normal5479 / 33603071630
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor65 / 124949520
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland11 / 33197331
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain6012 / 11009895460
cervix0 / 481710 
connective tissue0 / 1492550 
ear20 / 162121233
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye12 / 21105456
heart3 / 8962633
intestine10 / 23447242
kidney446 / 2117772105
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth0 / 670520 
muscle6 / 10771555
nerve26 / 157681648
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland0 / 201550 
skin72 / 210574341
spleen1 / 5395218
stomach0 / 966190 
testis41 / 330442124
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210198_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte12.9
AdrenalCortex7.5
Adrenalgland5.55
Amygdala8309.85
Appendix191.05
AtrioventricularNode285.7
BDCA4+_DentriticCells6.4
Bonemarrow7.45
BronchialEpithelialCells6.25
CD105+_Endothelial5.95
CD14+_Monocytes7.45
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid8.05
CD34+8.25
CD4+_Tcells6.75
CD56+_NKCells7.7
CD71+_EarlyErythroid6.05
CD8+_Tcells5.6
CardiacMyocytes8.35
Caudatenucleus5826.9
Cerebellum852.3
CerebellumPeduncles3050.1
CiliaryGanglion204.85
CingulateCortex4113.3
Colorectaladenocarcinoma5.65
DorsalRootGanglion657
FetalThyroid7.85
Fetalbrain34.65
Fetalliver6.1
Fetallung5.9
GlobusPallidus2641.2
Heart8.7
Hypothalamus9760.55
Kidney5.4
Leukemia_chronicMyelogenousK-5626.45
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.2
Liver8.7
Lung7.4
Lymphnode5.9
Lymphoma_burkitts(Daudi)7.85
Lymphoma_burkitts(Raji)8.55
MedullaOblongata8153.35
OccipitalLobe9391.55
OlfactoryBulb3496.55
Ovary5.4
Pancreas5.55
PancreaticIslet6.8
ParietalLobe10480.2
Pituitary9.45
Placenta6.3
Pons4529.3
PrefrontalCortex7148
Prostate9.5
Salivarygland5.5
SkeletalMuscle11
Skin5.2
SmoothMuscle7.1
Spinalcord12460.75
SubthalamicNucleus3443.7
SuperiorCervicalGanglion440.1
TemporalLobe1655.45
Testis12.7
TestisGermCell151.25
TestisIntersitial15.95
TestisLeydigCell10.45
TestisSeminiferousTubule16.45
Thalamus8214.75
Thymus5
Thyroid7.8
Tongue6.6
Tonsil5.75
Trachea9.4
TrigeminalGanglion471.15
Uterus11.55
UterusCorpus5.95
WholeBlood6.8
Wholebrain3632.45
colon13.45
pineal_day243.28
pineal_night246.08
retina6060.925
small_intestine13.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9863_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.54 ± 1.11
Basal Forebrain10.48 ± 0.79
Basal Part of Pons9.95 ± 0.8
Cerebellar Cortex9.01 ± 0.7
Cerebellar Nuclei11.43 ± 0.91
Claustrum9.12 ± 0.77
Epithalamus9.16 ± 1.62
Frontal Lobe9.6 ± 1.3
Globus Pallidus12.2 ± 0.38
Hypothalamus9.18 ± 0.73
Insula8.55 ± 1.03
Limbic Lobe8.88 ± 1.17
Mesencephalon9.9 ± 1.1
Myelencephalon9.81 ± 0.98
Occipital Lobe9.65 ± 1.02
Parietal Lobe9.44 ± 1.23
Pontine Tegmentum9.92 ± 0.75
Striatum10.47 ± 0.99
Subthalamus10.32 ± 0.34
Temporal Lobe9.26 ± 1.07
Thalamus10.51 ± 0.63
White Matter13.59 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plp1CBCerebellum98.05
100
Plp1CTXCerebral cortex98.21
99.66
Plp1HIPHippocampal region92.77
100
Plp1HPFHippocampal formation98.74
100
Plp1HYHypothalamus100
100
Plp1LSXLateral septal complex99.66
100
Plp1MBMidbrain100
100
Plp1MYMedulla100
100
Plp1OLFOlfactory bulb99.87
100
Plp1PPons100
100
Plp1PALPallidum100
100
Plp1RHPRetrohippocampal region100
100
Plp1sAMYStriatum-like amygdalar nuclei98.23
100
Plp1STRStriatum100
100
Plp1STRdStriatum dorsal region100
100
Plp1STRvStriatum ventral region97.27
100
Plp1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00077526 10 196 205 SIGSLCADAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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