AutismKB 2.0

Annotation Detail for PLP2


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Basic Information Top
Gene Symbol:PLP2 ( A4,A4LSB,MGC126187 )
Gene Full Name: proteolipid protein 2 (colonic epithelium-enriched)
Band: Xp11.23
Quick LinksEntrez ID:5355; OMIM: 300112; Uniprot ID:PLP2_HUMAN; ENSEMBL ID: ENSG00000102007; HGNC ID: 9087
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus22 / 56401239
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult316 / 1939121162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor21 / 94178222
cervical tumor15 / 34366436
chondrosarcoma17 / 82823205
colorectal tumor20 / 114246175
esophageal tumor2 / 17290115
gastrointestinal tumor108 / 119369904
germ cell tumor1 / 2638453
glioma12 / 106883112
head and neck tumor18 / 136302132
kidney tumor9 / 68959130
leukemia18 / 95842187
liver tumor2 / 9635920
lung tumor33 / 103127319
lymphoma2 / 7175527
non-neoplasia10 / 97250102
normal132 / 336030739
ovarian tumor21 / 76682273
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer10 / 10268097
retinoblastoma1 / 4635621
skin tumor22 / 124949176
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland6 / 33197180
ascites6 / 40015149
bladder1 / 2975733
blood18 / 123478145
bone22 / 71655307
bone marrow6 / 48801122
brain24 / 110098921
cervix19 / 48171394
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus2 / 2020998
eye14 / 21105466
heart5 / 8962655
intestine37 / 234472157
kidney15 / 21177770
larynx6 / 24145248
liver5 / 20774324
lung61 / 336974181
lymph1 / 4427022
lymph node5 / 9161054
mammary gland25 / 153271163
mouth8 / 67052119
muscle4 / 10771537
nerve0 / 157680 
ovary22 / 102051215
pancreas33 / 214812153
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta3 / 28082510
prostate12 / 18934563
salivary gland4 / 20155198
skin32 / 210574151
spleen3 / 5395255
stomach108 / 966191117
testis9 / 33044227
thymus2 / 8113124
thyroid1 / 4747321
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus28 / 232878120
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201136_at
Cell line Expression level Expression bar
721_B_lymphoblasts397.05
Adipocyte45.25
AdrenalCortex94.9
Adrenalgland587.6
Amygdala31.55
Appendix33.5
AtrioventricularNode21.85
BDCA4+_DentriticCells1314.9
Bonemarrow520.25
BronchialEpithelialCells1347.45
CD105+_Endothelial41.55
CD14+_Monocytes1221.85
CD19+_BCells(neg._sel.)821.55
CD33+_Myeloid1417.55
CD34+381.3
CD4+_Tcells333.7
CD56+_NKCells102.7
CD71+_EarlyErythroid30.55
CD8+_Tcells259.95
CardiacMyocytes453.25
Caudatenucleus21.15
Cerebellum22.6
CerebellumPeduncles20
CiliaryGanglion12.75
CingulateCortex26.25
Colorectaladenocarcinoma2071.4
DorsalRootGanglion14
FetalThyroid44.8
Fetalbrain22.55
Fetalliver27.8
Fetallung102.2
GlobusPallidus16.7
Heart145.75
Hypothalamus22.3
Kidney25.95
Leukemia_chronicMyelogenousK-562111
Leukemia_promyelocytic-HL-60105.65
Leukemialymphoblastic(MOLT-4)26.3
Liver41.65
Lung470.8
Lymphnode69.15
Lymphoma_burkitts(Daudi)194.65
Lymphoma_burkitts(Raji)110.25
MedullaOblongata28.6
OccipitalLobe16.1
OlfactoryBulb30.05
Ovary56.35
Pancreas179.95
PancreaticIslet188.85
ParietalLobe22.55
Pituitary145.45
Placenta51.4
Pons23.65
PrefrontalCortex21.2
Prostate122.3
Salivarygland25.75
SkeletalMuscle36.2
Skin69.25
SmoothMuscle68.05
Spinalcord24.85
SubthalamicNucleus25.4
SuperiorCervicalGanglion36.35
TemporalLobe23.1
Testis37.45
TestisGermCell42.85
TestisIntersitial18.8
TestisLeydigCell24.65
TestisSeminiferousTubule23.85
Thalamus22.6
Thymus371.9
Thyroid47.2
Tongue141.6
Tonsil176.9
Trachea103.35
TrigeminalGanglion30.95
Uterus171.15
UterusCorpus35.8
WholeBlood969.85
Wholebrain21.5
colon366.9
pineal_day19.12
pineal_night24.86
retina59.15
small_intestine270.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1394_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.31 ± 1.02
Basal Forebrain1.95 ± 0.29
Basal Part of Pons1.92 ± 0.48
Cerebellar Cortex2.7 ± 0.4
Cerebellar Nuclei2.25 ± 0.82
Claustrum2.7 ± 0.73
Epithalamus3.46 ± 0.69
Frontal Lobe2.02 ± 0.85
Globus Pallidus2.37 ± 0.79
Hypothalamus2.44 ± 0.91
Insula1.89 ± 0.5
Limbic Lobe1.94 ± 0.67
Mesencephalon2.3 ± 0.69
Myelencephalon2.16 ± 0.77
Occipital Lobe1.95 ± 0.68
Parietal Lobe1.88 ± 0.66
Pontine Tegmentum1.91 ± 0.73
Striatum1.96 ± 0.84
Subthalamus2.11 ± 0.7
Temporal Lobe2.02 ± 0.79
Thalamus2.01 ± 0.63
White Matter2.74 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plp2CBCerebellum100
100
Plp2CTXCerebral cortex100
100
Plp2HIPHippocampal region69.89
100
Plp2HPFHippocampal formation62.99
77.4
Plp2HYHypothalamus100
100
Plp2LSXLateral septal complex100
100
Plp2MBMidbrain95.85
94.14
Plp2MYMedulla94.72
100
Plp2OLFOlfactory bulb100
100
Plp2PPons88.46
89.56
Plp2PALPallidum100
100
Plp2RHPRetrohippocampal region50.32
41.84
Plp2sAMYStriatum-like amygdalar nuclei88.54
64.47
Plp2STRStriatum100
94.75
Plp2STRdStriatum dorsal region90.7
70.59
Plp2STRvStriatum ventral region100
100
Plp2THThalamus94.25
83.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096504 15 7 21 LSAPGCWAACTNFSR Peptide Atlas
PLP2_HUMAN_0 0 0 0 HTAAPTDPADGPV PRIDE
PLP2_HUMAN_139 13 139 151 HTAAPTDPADGPV PRIDE
PLP2_HUMAN_140 13 140 152 HTAAPTDPADGPV PRIDE
PLP2_HUMAN_7 15 7 21 LSAPGCWAACTNFSR PRIDE
PLP2_HUMAN_75 13 75 87 IPFINWPWSDFFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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