AutismKB 2.0

Annotation Detail for PLXNA1


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Basic Information Top
Gene Symbol:PLXNA1 ( DKFZp761P19121,NOV,NOVP,PLEXIN-A1,PLXN1 )
Gene Full Name: plexin A1
Band: 3q21.3
Quick LinksEntrez ID:5361; OMIM: 601055; Uniprot ID:PLXA1_HUMAN; ENSEMBL ID: ENSG00000114554; HGNC ID: 9099
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst9 / 62319144
fetus32 / 56401256
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult107 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor29 / 263845109
glioma9 / 10688384
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor15 / 103127145
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal169 / 336030750
ovarian tumor8 / 76682104
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor10 / 12494980
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder5 / 29757168
blood2 / 12347816
bone10 / 71655139
bone marrow0 / 488010 
brain71 / 110098964
cervix0 / 481710 
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye5 / 21105423
heart2 / 8962622
intestine9 / 23447238
kidney6 / 21177728
larynx5 / 24145207
liver2 / 2077439
lung30 / 33697489
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth3 / 6705244
muscle12 / 107715111
nerve0 / 157680 
ovary13 / 102051127
pancreas18 / 21481283
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta10 / 28082535
prostate6 / 18934531
salivary gland0 / 201550 
skin19 / 21057490
spleen0 / 539520 
stomach2 / 9661920
testis18 / 33044254
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221538_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.35
Adipocyte13.85
AdrenalCortex7.6
Adrenalgland6.1
Amygdala90.1
Appendix7.25
AtrioventricularNode5.4
BDCA4+_DentriticCells6.9
Bonemarrow7.05
BronchialEpithelialCells68.05
CD105+_Endothelial7.25
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)7.65
CD33+_Myeloid8.7
CD34+8.95
CD4+_Tcells7.95
CD56+_NKCells7.9
CD71+_EarlyErythroid6.7
CD8+_Tcells6.8
CardiacMyocytes21.8
Caudatenucleus6.45
Cerebellum7.2
CerebellumPeduncles8.8
CiliaryGanglion4.95
CingulateCortex28.45
Colorectaladenocarcinoma120.75
DorsalRootGanglion5.4
FetalThyroid7.15
Fetalbrain258.5
Fetalliver6.15
Fetallung8.6
GlobusPallidus6.85
Heart24.4
Hypothalamus24.4
Kidney5.8
Leukemia_chronicMyelogenousK-56293.5
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.85
Liver9.5
Lung106.35
Lymphnode8.65
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)19.25
MedullaOblongata14.4
OccipitalLobe19.5
OlfactoryBulb5.75
Ovary4.7
Pancreas5.85
PancreaticIslet7.7
ParietalLobe7.85
Pituitary8.25
Placenta19.6
Pons6.9
PrefrontalCortex101.7
Prostate19.85
Salivarygland5.75
SkeletalMuscle8.15
Skin5.5
SmoothMuscle23.3
Spinalcord7.7
SubthalamicNucleus14.55
SuperiorCervicalGanglion8.05
TemporalLobe9.1
Testis6.5
TestisGermCell11.9
TestisIntersitial6.05
TestisLeydigCell7.15
TestisSeminiferousTubule6.25
Thalamus7.35
Thymus12.35
Thyroid11
Tongue7
Tonsil7.05
Trachea6.1
TrigeminalGanglion7
Uterus16.25
UterusCorpus6.5
WholeBlood7.7
Wholebrain63.4
colon7.3
pineal_day8.88
pineal_night8.62
retina16.25
small_intestine7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P69068
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.4 ± 0.84
Basal Forebrain3.05 ± 0.73
Basal Part of Pons2.81 ± 0.49
Cerebellar Cortex2.96 ± 0.74
Cerebellar Nuclei3.09 ± 0.59
Claustrum3.37 ± 0.75
Epithalamus2.78 ± 1.05
Frontal Lobe3.19 ± 0.66
Globus Pallidus2.44 ± 0.5
Hypothalamus2.79 ± 0.59
Insula3.23 ± 0.54
Limbic Lobe3.31 ± 0.68
Mesencephalon3.04 ± 0.74
Myelencephalon3.07 ± 0.68
Occipital Lobe2.59 ± 0.72
Parietal Lobe3.23 ± 0.66
Pontine Tegmentum3.16 ± 0.82
Striatum2.2 ± 0.85
Subthalamus3.08 ± 0.82
Temporal Lobe3.35 ± 0.55
Thalamus2.8 ± 0.62
White Matter2.05 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plxna1CBCerebellum9.13
12.56
Plxna1CTXCerebral cortex39.88
28.81
Plxna1HIPHippocampal region33.72
62.57
Plxna1HPFHippocampal formation35.12
47.74
Plxna1HYHypothalamus15.7
10.96
Plxna1LSXLateral septal complex6.68
3.91
Plxna1MBMidbrain26.44
23.27
Plxna1MYMedulla18.08
19.23
Plxna1OLFOlfactory bulb15.78
12.6
Plxna1PPons18
17.68
Plxna1PALPallidum13.09
9.95
Plxna1RHPRetrohippocampal region37.44
31.01
Plxna1sAMYStriatum-like amygdalar nuclei21.56
14.03
Plxna1STRStriatum6.3
4.47
Plxna1STRdStriatum dorsal region4.96
3.57
Plxna1STRvStriatum ventral region4.82
3.85
Plxna1THThalamus12.55
9.96
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040722 15 841 855 HHCAADTPASWMHAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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