AutismKB 2.0

Annotation Detail for ADAM22


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Basic Information Top
Gene Symbol:ADAM22 ( MDC2,MGC149832 )
Gene Full Name: ADAM metallopeptidase domain 22
Band: 7q21.12
Quick LinksEntrez ID:53616; OMIM: 603709; Uniprot ID:ADA22_HUMAN; ENSEMBL ID: ENSG00000008277; HGNC ID: 201
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal17 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle3 / 10771527
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208237_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.95
Adipocyte3.95
AdrenalCortex4.45
Adrenalgland3.4
Amygdala4.2
Appendix6.2
AtrioventricularNode4.85
BDCA4+_DentriticCells4.4
Bonemarrow4.1
BronchialEpithelialCells3.95
CD105+_Endothelial4.15
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.25
CD33+_Myeloid5.1
CD34+5.1
CD4+_Tcells4.35
CD56+_NKCells4.8
CD71+_EarlyErythroid3.8
CD8+_Tcells3.85
CardiacMyocytes4.9
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.65
CiliaryGanglion3.75
CingulateCortex4.1
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.3
FetalThyroid4
Fetalbrain4
Fetalliver3.5
Fetallung3.35
GlobusPallidus3
Heart5.1
Hypothalamus4.4
Kidney3.25
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.25
Liver5.6
Lung4.45
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.7
MedullaOblongata3.7
OccipitalLobe3.6
OlfactoryBulb3.2
Ovary3.55
Pancreas3.2
PancreaticIslet4.35
ParietalLobe4.4
Pituitary4.8
Placenta4.1
Pons3.85
PrefrontalCortex5
Prostate4.7
Salivarygland3.3
SkeletalMuscle4.8
Skin6.95
SmoothMuscle4.55
Spinalcord4.3
SubthalamicNucleus3.65
SuperiorCervicalGanglion5.95
TemporalLobe3.75
Testis3.5
TestisGermCell3.4
TestisIntersitial3.45
TestisLeydigCell4.05
TestisSeminiferousTubule3.5
Thalamus4.05
Thymus3.2
Thyroid4.95
Tongue4.2
Tonsil3.9
Trachea3.35
TrigeminalGanglion6.65
Uterus3.25
UterusCorpus4.2
WholeBlood4.4
Wholebrain3.35
colon4.05
pineal_day5
pineal_night4.9
retina4.85
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9790_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.07 ± 0.5
Basal Forebrain7.06 ± 0.35
Basal Part of Pons7.69 ± 0.18
Cerebellar Cortex7.77 ± 0.25
Cerebellar Nuclei7.31 ± 0.42
Claustrum7.28 ± 0.52
Epithalamus7.31 ± 0.35
Frontal Lobe7.26 ± 0.41
Globus Pallidus6.26 ± 0.24
Hypothalamus7.34 ± 0.14
Insula7.26 ± 0.27
Limbic Lobe7.11 ± 0.71
Mesencephalon6.9 ± 0.54
Myelencephalon7.03 ± 0.57
Occipital Lobe7.32 ± 0.47
Parietal Lobe7.25 ± 0.55
Pontine Tegmentum7.21 ± 0.44
Striatum6.51 ± 0.41
Subthalamus7.67 ± 0.12
Temporal Lobe7.26 ± 0.43
Thalamus6.94 ± 0.4
White Matter6.02 ± 0.45
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018