AutismKB 2.0

Annotation Detail for PLXNB3


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Basic Information Top
Gene Symbol:PLXNB3 ( FLJ76953,PLEXB3,PLEXR,PLXN6 )
Gene Full Name: plexin B3
Band: Xq28
Quick LinksEntrez ID:5365; OMIM: 300214; Uniprot ID:PLXB3_HUMAN; ENSEMBL ID: ENSG00000198753; HGNC ID: 9105
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma15 / 106883140
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal77 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain76 / 110098969
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve2 / 15768126
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205957_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.35
Adipocyte7.7
AdrenalCortex8.65
Adrenalgland8.35
Amygdala50.95
Appendix8
AtrioventricularNode6.55
BDCA4+_DentriticCells6.5
Bonemarrow7.9
BronchialEpithelialCells6.9
CD105+_Endothelial6.6
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8.15
CD34+8.2
CD4+_Tcells7.8
CD56+_NKCells7.6
CD71+_EarlyErythroid7.25
CD8+_Tcells5.95
CardiacMyocytes8.95
Caudatenucleus27.7
Cerebellum7.85
CerebellumPeduncles11.85
CiliaryGanglion5.85
CingulateCortex11.45
Colorectaladenocarcinoma7.85
DorsalRootGanglion10.3
FetalThyroid7.2
Fetalbrain8.05
Fetalliver7.05
Fetallung5.7
GlobusPallidus11.7
Heart10
Hypothalamus19.85
Kidney6.5
Leukemia_chronicMyelogenousK-5627
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)6.15
Liver10.45
Lung8.4
Lymphnode6.5
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)11.15
MedullaOblongata48.9
OccipitalLobe16.15
OlfactoryBulb14.5
Ovary5.25
Pancreas6.25
PancreaticIslet7.85
ParietalLobe20.3
Pituitary9
Placenta7.95
Pons17.95
PrefrontalCortex109.3
Prostate8.4
Salivarygland7.25
SkeletalMuscle9.6
Skin6.25
SmoothMuscle8.65
Spinalcord49.3
SubthalamicNucleus9.45
SuperiorCervicalGanglion9.75
TemporalLobe8.4
Testis6.6
TestisGermCell7
TestisIntersitial7.05
TestisLeydigCell8.4
TestisSeminiferousTubule7.4
Thalamus20.7
Thymus5.65
Thyroid8.85
Tongue7.75
Tonsil7.45
Trachea6.55
TrigeminalGanglion8.6
Uterus6.05
UterusCorpus7.1
WholeBlood7.85
Wholebrain8.15
colon7.7
pineal_day9.68
pineal_night9.26
retina30.725
small_intestine7.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8449_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.46 ± 0.6
Basal Forebrain6.39 ± 0.63
Basal Part of Pons5.53 ± 0.61
Cerebellar Cortex5.04 ± 0.41
Cerebellar Nuclei6.7 ± 0.73
Claustrum6.04 ± 0.68
Epithalamus6.25 ± 0.38
Frontal Lobe5.47 ± 0.83
Globus Pallidus7.46 ± 0.35
Hypothalamus5.45 ± 0.57
Insula5.09 ± 0.61
Limbic Lobe5.38 ± 0.9
Mesencephalon5.94 ± 0.83
Myelencephalon5.83 ± 0.75
Occipital Lobe5.81 ± 0.75
Parietal Lobe5.67 ± 0.84
Pontine Tegmentum5.81 ± 0.72
Striatum6.4 ± 0.66
Subthalamus5.94 ± 0.44
Temporal Lobe5.41 ± 0.72
Thalamus6.12 ± 0.49
White Matter8.38 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plxnb3CBCerebellum2.34
2.43
Plxnb3CTXCerebral cortex2.04
1.58
Plxnb3HIPHippocampal region3.42
3.1
Plxnb3HPFHippocampal formation2.92
2.43
Plxnb3HYHypothalamus3.45
2.64
Plxnb3LSXLateral septal complex3.65
2.77
Plxnb3MBMidbrain4.34
3.38
Plxnb3MYMedulla6.8
4.87
Plxnb3OLFOlfactory bulb3.69
2.41
Plxnb3PPons7.44
4.91
Plxnb3PALPallidum4.75
3.74
Plxnb3RHPRetrohippocampal region2.06
1.49
Plxnb3sAMYStriatum-like amygdalar nuclei2.92
2.08
Plxnb3STRStriatum3.17
2.3
Plxnb3STRdStriatum dorsal region3.31
2.43
Plxnb3STRvStriatum ventral region2.75
1.85
Plxnb3THThalamus4.81
3.56
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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