AutismKB 2.0

Annotation Detail for PNOC


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Basic Information Top
Gene Symbol:PNOC ( PPNOC )
Gene Full Name: prepronociceptin
Band: 8p21.1
Quick LinksEntrez ID:5368; OMIM: 601459; Uniprot ID:PNOC_HUMAN; ENSEMBL ID: ENSG00000168081; HGNC ID: 9163
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal30 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node8 / 9161087
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205901_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.35
Adipocyte4.5
AdrenalCortex4.8
Adrenalgland3.8
Amygdala4.75
Appendix4.6
AtrioventricularNode3.55
BDCA4+_DentriticCells291.8
Bonemarrow4.5
BronchialEpithelialCells4.45
CD105+_Endothelial4.5
CD14+_Monocytes4.85
CD19+_BCells(neg._sel.)551.65
CD33+_Myeloid5.85
CD34+5.65
CD4+_Tcells4.85
CD56+_NKCells5.35
CD71+_EarlyErythroid4.25
CD8+_Tcells4.3
CardiacMyocytes5.8
Caudatenucleus4.1
Cerebellum3.65
CerebellumPeduncles5.1
CiliaryGanglion3.3
CingulateCortex4.8
Colorectaladenocarcinoma4.55
DorsalRootGanglion3.55
FetalThyroid4.4
Fetalbrain5.65
Fetalliver3.9
Fetallung3.75
GlobusPallidus3.4
Heart5.75
Hypothalamus5.2
Kidney3.65
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)3.6
Liver5.95
Lung4.95
Lymphnode4
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)7
MedullaOblongata4.4
OccipitalLobe4.05
OlfactoryBulb3.55
Ovary2.95
Pancreas3.65
PancreaticIslet4.8
ParietalLobe4.8
Pituitary5.3
Placenta4.65
Pons4.35
PrefrontalCortex5.6
Prostate5.25
Salivarygland3.65
SkeletalMuscle5.35
Skin3.45
SmoothMuscle5.1
Spinalcord4.85
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.3
TemporalLobe4.15
Testis3.85
TestisGermCell3.75
TestisIntersitial3.85
TestisLeydigCell4.5
TestisSeminiferousTubule3.9
Thalamus4.85
Thymus3.5
Thyroid5.65
Tongue4.5
Tonsil4.55
Trachea3.8
TrigeminalGanglion4.5
Uterus3.65
UterusCorpus4.05
WholeBlood4.95
Wholebrain5.6
colon4.55
pineal_day5.62
pineal_night5.48
retina5.4
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_516_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.72 ± 0.57
Basal Forebrain5.51 ± 0.44
Basal Part of Pons4.8 ± 0.5
Cerebellar Cortex5.53 ± 0.46
Cerebellar Nuclei5.92 ± 0.6
Claustrum5.82 ± 0.53
Epithalamus5.37 ± 0.37
Frontal Lobe6.11 ± 0.66
Globus Pallidus4.85 ± 0.82
Hypothalamus5.96 ± 1.15
Insula6.36 ± 0.46
Limbic Lobe5.77 ± 0.63
Mesencephalon6.02 ± 0.64
Myelencephalon5.78 ± 0.73
Occipital Lobe5.03 ± 0.68
Parietal Lobe5.74 ± 0.49
Pontine Tegmentum5.9 ± 0.59
Striatum4.75 ± 0.85
Subthalamus5.15 ± 1.03
Temporal Lobe6.09 ± 0.41
Thalamus5.7 ± 0.83
White Matter4.8 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PnocCBCerebellum17.33
20.59
PnocCTXCerebral cortex30.52
27.83
PnocHIPHippocampal region19.83
28.86
PnocHPFHippocampal formation25.24
30.75
PnocHYHypothalamus41.74
44.3
PnocLSXLateral septal complex68.66
87.02
PnocMBMidbrain29.22
35.31
PnocMYMedulla23.79
30.07
PnocOLFOlfactory bulb42.03
39.15
PnocPPons25.8
32.68
PnocPALPallidum38.16
48.99
PnocRHPRetrohippocampal region36.13
34.89
PnocsAMYStriatum-like amygdalar nuclei54.95
68.02
PnocSTRStriatum17.71
19.35
PnocSTRdStriatum dorsal region7.16
6.34
PnocSTRvStriatum ventral region10.76
8.85
PnocTHThalamus37.66
43.01
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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