AutismKB 2.0

Annotation Detail for DUOX1


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Basic Information Top
Gene Symbol:DUOX1 ( LNOX1,MGC138840,MGC138841,NOXEF1,THOX1 )
Gene Full Name: dual oxidase 1
Band: 15q21.1
Quick LinksEntrez ID:53905; OMIM: 606758; Uniprot ID:DUOX1_HUMAN; ENSEMBL ID: ENSG00000137857; HGNC ID: 3062
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor20 / 136302146
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal28 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder4 / 29757134
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth7 / 67052104
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid17 / 47473358
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219597_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.25
AdrenalCortex4.5
Adrenalgland3.7
Amygdala4.45
Appendix4.3
AtrioventricularNode3.25
BDCA4+_DentriticCells4.7
Bonemarrow4.45
BronchialEpithelialCells6.55
CD105+_Endothelial4.35
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.25
CD33+_Myeloid5.45
CD34+5.3
CD4+_Tcells4.65
CD56+_NKCells5.1
CD71+_EarlyErythroid4
CD8+_Tcells3.85
CardiacMyocytes6.5
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles5.8
CiliaryGanglion3.3
CingulateCortex4.35
Colorectaladenocarcinoma4.3
DorsalRootGanglion3.25
FetalThyroid78.6
Fetalbrain4.25
Fetalliver3.7
Fetallung8.75
GlobusPallidus3.25
Heart5.55
Hypothalamus4.65
Kidney3.5
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.45
Liver6
Lung82.7
Lymphnode3.7
Lymphoma_burkitts(Daudi)5.45
Lymphoma_burkitts(Raji)6.05
MedullaOblongata3.95
OccipitalLobe3.8
OlfactoryBulb3.35
Ovary2.8
Pancreas3.5
PancreaticIslet4.6
ParietalLobe4.5
Pituitary4.95
Placenta4.45
Pons4.15
PrefrontalCortex5.3
Prostate6.2
Salivarygland3.4
SkeletalMuscle5.3
Skin4.8
SmoothMuscle4.8
Spinalcord4.55
SubthalamicNucleus3.9
SuperiorCervicalGanglion4.85
TemporalLobe3.95
Testis3.6
TestisGermCell3.6
TestisIntersitial3.6
TestisLeydigCell4.2
TestisSeminiferousTubule3.6
Thalamus4.35
Thymus3.4
Thyroid130.9
Tongue73
Tonsil4.35
Trachea9.95
TrigeminalGanglion4.25
Uterus3.5
UterusCorpus3.85
WholeBlood4.65
Wholebrain3.6
colon4.25
pineal_day5.22
pineal_night5.22
retina5.525
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15758_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.98 ± 1.04
Basal Forebrain1.54 ± 0.17
Basal Part of Pons1.37 ± 0.45
Cerebellar Cortex1.65 ± 0.81
Cerebellar Nuclei2.02 ± 0.67
Claustrum2.36 ± 0.83
Epithalamus1.22 ± 0.77
Frontal Lobe1.41 ± 0.79
Globus Pallidus2.17 ± 0.56
Hypothalamus1.65 ± 0.82
Insula1.44 ± 0.56
Limbic Lobe1.56 ± 0.66
Mesencephalon1.72 ± 0.86
Myelencephalon1.55 ± 0.65
Occipital Lobe1.6 ± 0.61
Parietal Lobe1.52 ± 0.66
Pontine Tegmentum1.55 ± 0.57
Striatum1.53 ± 0.48
Subthalamus1.93 ± 0.64
Temporal Lobe1.43 ± 0.58
Thalamus1.54 ± 0.6
White Matter2.03 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Duox1CBCerebellum2.42
4.3
Duox1CTXCerebral cortex1.06
1.81
Duox1HIPHippocampal region0.71
1.13
Duox1HPFHippocampal formation0.67
0.88
Duox1HYHypothalamus0.38
1.02
Duox1LSXLateral septal complex0.05
0.08
Duox1MBMidbrain0.5
0.69
Duox1MYMedulla0.74
0.82
Duox1OLFOlfactory bulb1.84
3.17
Duox1PPons0.32
0.53
Duox1PALPallidum0.19
0.26
Duox1RHPRetrohippocampal region0.49
0.37
Duox1sAMYStriatum-like amygdalar nuclei0.26
0.39
Duox1STRStriatum0.3
0.36
Duox1STRdStriatum dorsal region0.43
0.49
Duox1STRvStriatum ventral region0.08
0.21
Duox1THThalamus0.71
0.97
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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