AutismKB 2.0

Annotation Detail for PRRX1


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Basic Information Top
Gene Symbol:PRRX1 ( PHOX1,PMX1,PRX1 )
Gene Full Name: paired related homeobox 1
Band: 1q24.2
Quick LinksEntrez ID:5396; OMIM: 167420; Uniprot ID:PRRX1_HUMAN; ENSEMBL ID: ENSG00000116132; HGNC ID: 9142
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus35 / 56401262
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma9 / 82823108
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma5 / 10688346
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia9 / 9725092
normal100 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone5 / 7165569
bone marrow1 / 4880120
brain11 / 11009899
cervix0 / 481710 
connective tissue12 / 14925580
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye12 / 21105456
heart13 / 89626145
intestine2 / 2344728
kidney4 / 21177718
larynx1 / 2414541
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth4 / 6705259
muscle4 / 10771537
nerve2 / 15768126
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta3 / 28082510
prostate10 / 18934552
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus21 / 23287890
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205991_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.85
Adipocyte185.2
AdrenalCortex6.4
Adrenalgland5.05
Amygdala6.15
Appendix11.15
AtrioventricularNode20.7
BDCA4+_DentriticCells6.35
Bonemarrow5.8
BronchialEpithelialCells5.85
CD105+_Endothelial6.05
CD14+_Monocytes6.2
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid8.8
CD34+7.6
CD4+_Tcells6.65
CD56+_NKCells6.9
CD71+_EarlyErythroid5.7
CD8+_Tcells5.7
CardiacMyocytes38.6
Caudatenucleus5.2
Cerebellum4.85
CerebellumPeduncles6.85
CiliaryGanglion19.6
CingulateCortex6.05
Colorectaladenocarcinoma5.9
DorsalRootGanglion23.9
FetalThyroid6.05
Fetalbrain5.75
Fetalliver5.2
Fetallung5.15
GlobusPallidus4.4
Heart7.95
Hypothalamus6.55
Kidney4.9
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-605.25
Leukemialymphoblastic(MOLT-4)4.8
Liver10.85
Lung6.55
Lymphnode9.15
Lymphoma_burkitts(Daudi)7.7
Lymphoma_burkitts(Raji)8.6
MedullaOblongata5.45
OccipitalLobe5.55
OlfactoryBulb4.75
Ovary12.95
Pancreas4.8
PancreaticIslet8.25
ParietalLobe6.7
Pituitary6.95
Placenta6.05
Pons5.7
PrefrontalCortex7.2
Prostate7.05
Salivarygland6.65
SkeletalMuscle7.1
Skin12.95
SmoothMuscle58.35
Spinalcord6.4
SubthalamicNucleus5.4
SuperiorCervicalGanglion25.3
TemporalLobe5.45
Testis5.05
TestisGermCell12.2
TestisIntersitial7.6
TestisLeydigCell6.25
TestisSeminiferousTubule5.1
Thalamus6
Thymus4.4
Thyroid9.65
Tongue10.1
Tonsil12.65
Trachea27.35
TrigeminalGanglion11.2
Uterus15.45
UterusCorpus22.85
WholeBlood6.45
Wholebrain4.75
colon5.85
pineal_day7.38
pineal_night7.16
retina12.075
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9244_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.68 ± 0.46
Basal Forebrain7.11 ± 0.16
Basal Part of Pons6.53 ± 0.19
Cerebellar Cortex6.49 ± 0.27
Cerebellar Nuclei6.84 ± 0.3
Claustrum6.4 ± 0.31
Epithalamus6.95 ± 0.52
Frontal Lobe7.06 ± 0.33
Globus Pallidus8.12 ± 0.27
Hypothalamus7 ± 0.41
Insula6.49 ± 0.27
Limbic Lobe6.76 ± 0.47
Mesencephalon7.05 ± 0.43
Myelencephalon6.75 ± 0.49
Occipital Lobe6.52 ± 0.5
Parietal Lobe6.57 ± 0.33
Pontine Tegmentum6.76 ± 0.4
Striatum7.2 ± 0.48
Subthalamus6.85 ± 0.45
Temporal Lobe6.34 ± 0.33
Thalamus6.97 ± 0.36
White Matter7.12 ± 0.21
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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