AutismKB 2.0

Annotation Detail for BRWD1


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Basic Information Top
Gene Symbol:BRWD1 ( C21orf107,FLJ43918,N143,WDR9 )
Gene Full Name: bromodomain and WD repeat domain containing 1
Band: 21q22.2
Quick LinksEntrez ID:54014; OMIM: NA; Uniprot ID:BRWD1_HUMAN; ENSEMBL ID: ENSG00000185658; HGNC ID: 12760
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst5 / 6231980
fetus57 / 564012101
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor14 / 94178148
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor22 / 26384583
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal292 / 336030786
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder0 / 297570 
blood6 / 12347848
bone2 / 7165527
bone marrow1 / 4880120
brain77 / 110098969
cervix2 / 4817141
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye15 / 21105471
heart5 / 8962655
intestine12 / 23447251
kidney17 / 21177780
larynx0 / 241450 
liver7 / 20774333
lung22 / 33697465
lymph1 / 4427022
lymph node16 / 91610174
mammary gland27 / 153271176
mouth5 / 6705274
muscle13 / 107715120
nerve1 / 1576863
ovary4 / 10205139
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta33 / 280825117
prostate6 / 18934531
salivary gland2 / 2015599
skin5 / 21057423
spleen5 / 5395292
stomach2 / 9661920
testis34 / 330442102
thymus12 / 81131147
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214820_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.45
Adipocyte8
AdrenalCortex11.9
Adrenalgland7.55
Amygdala7.9
Appendix12.4
AtrioventricularNode10.35
BDCA4+_DentriticCells8.5
Bonemarrow10.3
BronchialEpithelialCells7.95
CD105+_Endothelial8.55
CD14+_Monocytes9.3
CD19+_BCells(neg._sel.)9.15
CD33+_Myeloid10.2
CD34+9.45
CD4+_Tcells9
CD56+_NKCells9.35
CD71+_EarlyErythroid8.3
CD8+_Tcells7.75
CardiacMyocytes17.35
Caudatenucleus7.45
Cerebellum6.9
CerebellumPeduncles10.85
CiliaryGanglion9.9
CingulateCortex8.9
Colorectaladenocarcinoma8.25
DorsalRootGanglion9
FetalThyroid9.4
Fetalbrain8.4
Fetalliver7.35
Fetallung6.65
GlobusPallidus7.35
Heart13.75
Hypothalamus8.2
Kidney8.15
Leukemia_chronicMyelogenousK-5627.5
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)6.25
Liver15.5
Lung9
Lymphnode6.55
Lymphoma_burkitts(Daudi)11
Lymphoma_burkitts(Raji)12.9
MedullaOblongata7.55
OccipitalLobe7.4
OlfactoryBulb6.4
Ovary7
Pancreas7.1
PancreaticIslet9.1
ParietalLobe10.2
Pituitary9.65
Placenta8
Pons8.6
PrefrontalCortex9.3
Prostate9.1
Salivarygland7.4
SkeletalMuscle16.1
Skin9.05
SmoothMuscle9.4
Spinalcord8.65
SubthalamicNucleus8.5
SuperiorCervicalGanglion14.65
TemporalLobe8.25
Testis7.2
TestisGermCell6.7
TestisIntersitial8.2
TestisLeydigCell9.75
TestisSeminiferousTubule7.45
Thalamus8.8
Thymus6
Thyroid9.5
Tongue10.25
Tonsil8.55
Trachea6.95
TrigeminalGanglion13.7
Uterus6.9
UterusCorpus9.6
WholeBlood9
Wholebrain6.2
colon8.25
pineal_day10.12
pineal_night9.94
retina9.975
small_intestine7.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P211136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.52 ± 0.18
Basal Forebrain6.46 ± 0.09
Basal Part of Pons6.28 ± 0.26
Cerebellar Cortex6.6 ± 0.21
Cerebellar Nuclei6.19 ± 0.4
Claustrum6.74 ± 0.36
Epithalamus6.08 ± 0.25
Frontal Lobe6.22 ± 0.34
Globus Pallidus6.06 ± 0.42
Hypothalamus6.35 ± 0.27
Insula6.19 ± 0.33
Limbic Lobe6.36 ± 0.42
Mesencephalon6.38 ± 0.37
Myelencephalon6.33 ± 0.38
Occipital Lobe6.79 ± 0.3
Parietal Lobe6.48 ± 0.29
Pontine Tegmentum6.36 ± 0.37
Striatum6.48 ± 0.33
Subthalamus6.25 ± 0.22
Temporal Lobe6.25 ± 0.31
Thalamus6.27 ± 0.29
White Matter6.72 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brwd1CBCerebellum23.73
17.24
Brwd1CTXCerebral cortex61.52
35.09
Brwd1HIPHippocampal region66.58
59.16
Brwd1HPFHippocampal formation66.44
50.7
Brwd1HYHypothalamus52
28.32
Brwd1LSXLateral septal complex71.47
38.96
Brwd1MBMidbrain28.87
18.12
Brwd1MYMedulla37.04
28.05
Brwd1OLFOlfactory bulb92.34
48.93
Brwd1PPons38.69
28.43
Brwd1PALPallidum32.77
19.45
Brwd1RHPRetrohippocampal region68.49
40.77
Brwd1sAMYStriatum-like amygdalar nuclei40.39
21.82
Brwd1STRStriatum43.98
23.41
Brwd1STRdStriatum dorsal region36.11
19.52
Brwd1STRvStriatum ventral region62.93
30.72
Brwd1THThalamus33.88
20.51
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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