AutismKB 2.0

Annotation Detail for RIPK4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RIPK4 ( ANKK2,ANKRD3,DIK,MGC129992,MGC129993,PKK,RIP4 )
Gene Full Name: receptor-interacting serine-threonine kinase 4
Band: 21q22.3
Quick LinksEntrez ID:54101; OMIM: 605706; Uniprot ID:Q96T11_HUMAN; ENSEMBL ID: ENSG00000183421; HGNC ID: 496
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor27 / 136302198
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal39 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye4 / 21105418
heart3 / 8962633
intestine4 / 23447217
kidney13 / 21177761
larynx1 / 2414541
liver3 / 20774314
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth23 / 67052343
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta2 / 2808257
prostate6 / 18934531
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach4 / 9661941
testis9 / 33044227
thymus8 / 8113198
thyroid1 / 4747321
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221215_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.35
Adipocyte4.95
AdrenalCortex4.95
Adrenalgland5.45
Amygdala5.35
Appendix4.35
AtrioventricularNode3.6
BDCA4+_DentriticCells5.6
Bonemarrow11.45
BronchialEpithelialCells21.85
CD105+_Endothelial5.05
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid6.45
CD34+5.3
CD4+_Tcells4.65
CD56+_NKCells5.25
CD71+_EarlyErythroid4.45
CD8+_Tcells4.65
CardiacMyocytes5.9
Caudatenucleus4.45
Cerebellum8.2
CerebellumPeduncles5.45
CiliaryGanglion3.25
CingulateCortex4.9
Colorectaladenocarcinoma31.65
DorsalRootGanglion3.25
FetalThyroid4.8
Fetalbrain5
Fetalliver7.1
Fetallung5.5
GlobusPallidus3.5
Heart17.85
Hypothalamus4.95
Kidney22.3
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4.85
Liver53.15
Lung88.2
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.3
Lymphoma_burkitts(Raji)6.85
MedullaOblongata3.8
OccipitalLobe4.5
OlfactoryBulb3.75
Ovary3.25
Pancreas5.7
PancreaticIslet12.2
ParietalLobe5.05
Pituitary7.55
Placenta10.7
Pons4.7
PrefrontalCortex5.7
Prostate115.9
Salivarygland7.3
SkeletalMuscle5.55
Skin18.55
SmoothMuscle5.7
Spinalcord5.3
SubthalamicNucleus4.45
SuperiorCervicalGanglion5.15
TemporalLobe4.3
Testis10.55
TestisGermCell4.15
TestisIntersitial3.7
TestisLeydigCell4.9
TestisSeminiferousTubule4.25
Thalamus5.05
Thymus36.2
Thyroid59.1
Tongue34.2
Tonsil6.3
Trachea27.35
TrigeminalGanglion4.4
Uterus4.1
UterusCorpus3.8
WholeBlood5.5
Wholebrain4.15
colon8.05
pineal_day5.58
pineal_night5.3
retina12.425
small_intestine10.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P211267
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.34 ± 1.04
Basal Forebrain1.81 ± 0.44
Basal Part of Pons1.81 ± 0.8
Cerebellar Cortex2 ± 0.59
Cerebellar Nuclei1.97 ± 0.81
Claustrum2.62 ± 0.7
Epithalamus1.59 ± 0.74
Frontal Lobe1.93 ± 0.82
Globus Pallidus2.08 ± 0.71
Hypothalamus1.84 ± 0.83
Insula1.78 ± 0.65
Limbic Lobe1.96 ± 0.72
Mesencephalon2.02 ± 0.79
Myelencephalon2 ± 0.74
Occipital Lobe2.03 ± 0.81
Parietal Lobe1.88 ± 0.75
Pontine Tegmentum1.84 ± 0.75
Striatum1.92 ± 0.8
Subthalamus1.76 ± 0.58
Temporal Lobe1.81 ± 0.78
Thalamus1.9 ± 0.66
White Matter1.94 ± 0.89
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved