AutismKB 2.0

Annotation Detail for POLR2F


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:POLR2F ( HRBP14.4,POLRF,RPABC2,RPB14.4,RPB6 )
Gene Full Name: polymerase (RNA) II (DNA directed) polypeptide F
Band: 22q13.1
Quick LinksEntrez ID:5435; OMIM: 604414; Uniprot ID:RPAB2_HUMAN; ENSEMBL ID: ENSG00000100142; HGNC ID: 9193
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus40 / 56401270
neonate3 / 3109796
infant0 / 236200 
juvenile4 / 5555671
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor19 / 26384572
glioma15 / 106883140
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia5 / 9584252
liver tumor6 / 9635962
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal190 / 336030756
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor23 / 124949184
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites4 / 4001599
bladder1 / 2975733
blood5 / 12347840
bone3 / 7165541
bone marrow2 / 4880140
brain108 / 110098998
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye20 / 21105494
heart13 / 89626145
intestine18 / 23447276
kidney13 / 21177761
larynx0 / 241450 
liver7 / 20774333
lung7 / 33697420
lymph0 / 442700 
lymph node6 / 9161065
mammary gland2 / 15327113
mouth1 / 6705214
muscle8 / 10771574
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate13 / 18934568
salivary gland1 / 2015549
skin25 / 210574118
spleen0 / 539520 
stomach5 / 9661951
testis12 / 33044236
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209511_at
Cell line Expression level Expression bar
721_B_lymphoblasts286.75
Adipocyte152.3
AdrenalCortex131.5
Adrenalgland101.6
Amygdala126.65
Appendix121.55
AtrioventricularNode84.3
BDCA4+_DentriticCells171.8
Bonemarrow115.1
BronchialEpithelialCells220.1
CD105+_Endothelial480.6
CD14+_Monocytes250.15
CD19+_BCells(neg._sel.)223.7
CD33+_Myeloid238.75
CD34+412.15
CD4+_Tcells144.55
CD56+_NKCells188.75
CD71+_EarlyErythroid223.85
CD8+_Tcells121.25
CardiacMyocytes217.5
Caudatenucleus100.15
Cerebellum88.6
CerebellumPeduncles148.95
CiliaryGanglion67.95
CingulateCortex126.4
Colorectaladenocarcinoma292.2
DorsalRootGanglion69.75
FetalThyroid122.3
Fetalbrain109.55
Fetalliver100.25
Fetallung106.5
GlobusPallidus54.15
Heart447.8
Hypothalamus152.5
Kidney85.15
Leukemia_chronicMyelogenousK-562136.65
Leukemia_promyelocytic-HL-60224.3
Leukemialymphoblastic(MOLT-4)219.05
Liver554.05
Lung221.4
Lymphnode83.75
Lymphoma_burkitts(Daudi)287.75
Lymphoma_burkitts(Raji)196
MedullaOblongata107.75
OccipitalLobe111.35
OlfactoryBulb148.8
Ovary91.4
Pancreas75.75
PancreaticIslet146.7
ParietalLobe108.65
Pituitary169.3
Placenta136.15
Pons88.85
PrefrontalCortex129.65
Prostate211.15
Salivarygland105.3
SkeletalMuscle127.5
Skin75.6
SmoothMuscle258.5
Spinalcord155.2
SubthalamicNucleus111.5
SuperiorCervicalGanglion59.05
TemporalLobe105.65
Testis115.2
TestisGermCell118.9
TestisIntersitial117.7
TestisLeydigCell130.95
TestisSeminiferousTubule123.6
Thalamus131.55
Thymus108.05
Thyroid328.15
Tongue126.35
Tonsil124.1
Trachea86.05
TrigeminalGanglion133.25
Uterus200.8
UterusCorpus121.9
WholeBlood184.5
Wholebrain206.9
colon136.2
pineal_day180.08
pineal_night191.28
retina200.7
small_intestine110.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P417007
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.8 ± 0.52
Basal Forebrain7.5 ± 0.25
Basal Part of Pons8.2 ± 0.29
Cerebellar Cortex7.96 ± 0.21
Cerebellar Nuclei7.97 ± 0.27
Claustrum7.95 ± 0.27
Epithalamus6.88 ± 0.27
Frontal Lobe7.86 ± 0.42
Globus Pallidus7.07 ± 0.23
Hypothalamus7.28 ± 0.46
Insula7.71 ± 0.34
Limbic Lobe7.79 ± 0.33
Mesencephalon7.71 ± 0.36
Myelencephalon7.71 ± 0.42
Occipital Lobe7.71 ± 0.39
Parietal Lobe7.9 ± 0.38
Pontine Tegmentum7.6 ± 0.32
Striatum7.29 ± 0.34
Subthalamus7.88 ± 0.13
Temporal Lobe7.78 ± 0.35
Thalamus7.7 ± 0.33
White Matter6.39 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Polr2fCBCerebellum7.1
6.35
Polr2fCTXCerebral cortex12.3
4.75
Polr2fHIPHippocampal region10.89
8.76
Polr2fHPFHippocampal formation9.96
6.4
Polr2fHYHypothalamus0.66
0.23
Polr2fLSXLateral septal complex0.31
0.21
Polr2fMBMidbrain2.59
1.52
Polr2fMYMedulla9.06
6.46
Polr2fOLFOlfactory bulb8.07
4.82
Polr2fPPons5.23
3.09
Polr2fPALPallidum2.12
0.97
Polr2fRHPRetrohippocampal region8.67
3.53
Polr2fsAMYStriatum-like amygdalar nuclei0.83
0.36
Polr2fSTRStriatum1.06
0.49
Polr2fSTRdStriatum dorsal region1.22
0.6
Polr2fSTRvStriatum ventral region0.83
0.29
Polr2fTHThalamus3.75
1.63
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved