AutismKB 2.0

Annotation Detail for SEMA5B


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Basic Information Top
Gene Symbol:SEMA5B ( FLJ10372,KIAA1445,SEMAG,SemG )
Gene Full Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Band: 3q21.1
Quick LinksEntrez ID:54437; OMIM: 609298; Uniprot ID:SEM5B_HUMAN; ENSEMBL ID: ENSG00000082684; HGNC ID: 10737
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst8 / 62319128
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor8 / 26384530
glioma11 / 106883102
head and neck tumor1 / 1363027
kidney tumor6 / 6895987
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal65 / 336030719
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain48 / 110098943
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine1 / 2344724
kidney8 / 21177737
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_566_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.6 ± 0.56
Basal Forebrain6.29 ± 0.21
Basal Part of Pons5.67 ± 0.4
Cerebellar Cortex5.5 ± 0.48
Cerebellar Nuclei6.03 ± 0.2
Claustrum6.38 ± 0.73
Epithalamus5.37 ± 0.26
Frontal Lobe5.91 ± 0.41
Globus Pallidus6.2 ± 0.51
Hypothalamus5.63 ± 0.36
Insula5.84 ± 0.61
Limbic Lobe6.54 ± 0.69
Mesencephalon6.03 ± 0.53
Myelencephalon6.03 ± 0.53
Occipital Lobe6.64 ± 0.75
Parietal Lobe6.2 ± 0.53
Pontine Tegmentum6.21 ± 0.53
Striatum6.01 ± 0.67
Subthalamus5.58 ± 0.17
Temporal Lobe6.22 ± 0.48
Thalamus5.69 ± 0.37
White Matter5.89 ± 0.66
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sema5bCBCerebellum0.38
0.75
Sema5bCTXCerebral cortex1.66
1.33
Sema5bHIPHippocampal region2.27
1.93
Sema5bHPFHippocampal formation1.67
1.27
Sema5bHYHypothalamus0.2
0.15
Sema5bLSXLateral septal complex0.56
0.81
Sema5bMBMidbrain0.36
0.34
Sema5bMYMedulla0.42
0.35
Sema5bOLFOlfactory bulb3.25
2.18
Sema5bPPons0.53
0.46
Sema5bPALPallidum0.81
0.81
Sema5bRHPRetrohippocampal region0.92
0.54
Sema5bsAMYStriatum-like amygdalar nuclei0.5
0.39
Sema5bSTRStriatum4.12
3.15
Sema5bSTRdStriatum dorsal region4.07
3.32
Sema5bSTRvStriatum ventral region7.97
4.84
Sema5bTHThalamus0.18
0.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018