AutismKB 2.0

Annotation Detail for PON1


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Basic Information Top
Gene Symbol:PON1 ( ESA,MVCD5,PON )
Gene Full Name: paraoxonase 1
Band: 7q21.3
Quick LinksEntrez ID:5444; OMIM: 168820; Uniprot ID:PON1_HUMAN; ENSEMBL ID: ENSG00000005421; HGNC ID: 9204
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor9 / 9635993
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal34 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver30 / 207743144
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206344_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.15
Adipocyte7.3
AdrenalCortex9.3
Adrenalgland6.85
Amygdala7.6
Appendix10.5
AtrioventricularNode6.7
BDCA4+_DentriticCells7.4
Bonemarrow8
BronchialEpithelialCells7
CD105+_Endothelial7.45
CD14+_Monocytes7.8
CD19+_BCells(neg._sel.)7.6
CD33+_Myeloid8.9
CD34+8.95
CD4+_Tcells7.8
CD56+_NKCells8.15
CD71+_EarlyErythroid7.2
CD8+_Tcells6.75
CardiacMyocytes11.2
Caudatenucleus6.8
Cerebellum6.2
CerebellumPeduncles9
CiliaryGanglion6
CingulateCortex7.8
Colorectaladenocarcinoma7.55
DorsalRootGanglion6.8
FetalThyroid7.55
Fetalbrain7.2
Fetalliver6.7
Fetallung5.75
GlobusPallidus5.8
Heart12.75
Hypothalamus7.7
Kidney6.7
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-606.55
Leukemialymphoblastic(MOLT-4)5.8
Liver11.8
Lung8.05
Lymphnode6.35
Lymphoma_burkitts(Daudi)9.85
Lymphoma_burkitts(Raji)11.4
MedullaOblongata6.75
OccipitalLobe6.65
OlfactoryBulb5.85
Ovary5.5
Pancreas6.2
PancreaticIslet8.05
ParietalLobe8.35
Pituitary8.7
Placenta7.25
Pons7.4
PrefrontalCortex8.85
Prostate8.45
Salivarygland6.35
SkeletalMuscle10.3
Skin7.1
SmoothMuscle8.35
Spinalcord7.95
SubthalamicNucleus7.1
SuperiorCervicalGanglion10
TemporalLobe8.85
Testis6.4
TestisGermCell6.05
TestisIntersitial6.4
TestisLeydigCell7.8
TestisSeminiferousTubule6.45
Thalamus7.75
Thymus5.6
Thyroid8.9
Tongue7.95
Tonsil7.55
Trachea6.25
TrigeminalGanglion9.25
Uterus5.8
UterusCorpus7.3
WholeBlood7.95
Wholebrain6.05
colon7.4
pineal_day9.14
pineal_night8.8
retina8.975
small_intestine7.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15679_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.55 ± 1
Basal Forebrain2.32 ± 0.4
Basal Part of Pons1.61 ± 0.51
Cerebellar Cortex2 ± 0.68
Cerebellar Nuclei2.48 ± 0.79
Claustrum2.97 ± 0.75
Epithalamus2.28 ± 0.54
Frontal Lobe2.04 ± 0.7
Globus Pallidus3.59 ± 0.91
Hypothalamus2.39 ± 0.41
Insula1.97 ± 0.54
Limbic Lobe2.21 ± 0.74
Mesencephalon2.62 ± 0.73
Myelencephalon2.3 ± 0.67
Occipital Lobe2.29 ± 0.89
Parietal Lobe2.26 ± 0.76
Pontine Tegmentum2.34 ± 0.73
Striatum2.51 ± 0.68
Subthalamus2.28 ± 0.66
Temporal Lobe2.07 ± 0.67
Thalamus2.29 ± 0.61
White Matter2.49 ± 0.43
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024047 17 322 338 AENGTVLQGSTVASVYK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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