AutismKB 2.0

Annotation Detail for ADAMTSL4


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Basic Information Top
Gene Symbol:ADAMTSL4 ( TSRC1 )
Gene Full Name: ADAMTS-like 4
Band: 1q21.2
Quick LinksEntrez ID:54507; OMIM: 610113; Uniprot ID:ATL4_HUMAN; ENSEMBL ID: ENSG00000143382; HGNC ID: 19706
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst4 / 6231964
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma9 / 82823108
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal137 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow3 / 4880161
brain3 / 11009892
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye4 / 21105418
heart3 / 8962633
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver6 / 20774328
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta81 / 280825288
prostate3 / 18934515
salivary gland1 / 2015549
skin4 / 21057418
spleen2 / 5395237
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1175_PI416573500
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.51 ± 1.01
Basal Forebrain2.04 ± 0.4
Basal Part of Pons1.65 ± 0.58
Cerebellar Cortex1.84 ± 0.77
Cerebellar Nuclei2.6 ± 0.72
Claustrum2.86 ± 1
Epithalamus1.63 ± 0.67
Frontal Lobe2.02 ± 0.9
Globus Pallidus2.04 ± 0.64
Hypothalamus1.89 ± 0.63
Insula1.57 ± 0.61
Limbic Lobe2.06 ± 0.74
Mesencephalon2.46 ± 0.88
Myelencephalon2.17 ± 0.76
Occipital Lobe2.11 ± 0.71
Parietal Lobe2.13 ± 0.79
Pontine Tegmentum2.01 ± 0.7
Striatum2.52 ± 1.05
Subthalamus2.47 ± 0.37
Temporal Lobe1.98 ± 0.74
Thalamus2.16 ± 0.68
White Matter2.15 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adamtsl4CBCerebellum2.28
2.45
Adamtsl4CTXCerebral cortex3.23
2.26
Adamtsl4HIPHippocampal region1.62
1.54
Adamtsl4HPFHippocampal formation1.23
1.14
Adamtsl4HYHypothalamus0.4
0.35
Adamtsl4LSXLateral septal complex0.13
0.07
Adamtsl4MBMidbrain2
1.74
Adamtsl4MYMedulla5.54
5.23
Adamtsl4OLFOlfactory bulb1.16
0.91
Adamtsl4PPons3.88
4.1
Adamtsl4PALPallidum1.16
0.89
Adamtsl4RHPRetrohippocampal region0.48
0.48
Adamtsl4sAMYStriatum-like amygdalar nuclei0.41
0.3
Adamtsl4STRStriatum0.9
0.63
Adamtsl4STRdStriatum dorsal region1.14
0.79
Adamtsl4STRvStriatum ventral region0.59
0.45
Adamtsl4THThalamus1.79
1.36
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00377271 17 782 798 LCGHWEVGSPWSQCSVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018