AutismKB 2.0

Annotation Detail for MIER2


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Basic Information Top
Gene Symbol:MIER2 ( KIAA1193 )
Gene Full Name: mesoderm induction early response 1, family member 2
Band: 19p13.3
Quick LinksEntrez ID:54531; OMIM: NA; Uniprot ID:MIER2_HUMAN; ENSEMBL ID: ENSG00000105556; HGNC ID: 29210
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor10 / 10312796
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal53 / 336030715
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone2 / 7165527
bone marrow0 / 488010 
brain15 / 110098913
cervix3 / 4817162
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine2 / 2344728
kidney5 / 21177723
larynx1 / 2414541
liver5 / 20774324
lung13 / 33697438
lymph1 / 4427022
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary5 / 10205148
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta6 / 28082521
prostate5 / 18934526
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach1 / 9661910
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221863_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.25
Adipocyte5.3
AdrenalCortex6.15
Adrenalgland4.6
Amygdala5.6
Appendix5.55
AtrioventricularNode4
BDCA4+_DentriticCells5.65
Bonemarrow5.35
BronchialEpithelialCells4.85
CD105+_Endothelial5.4
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5.6
CD33+_Myeloid7
CD34+6.45
CD4+_Tcells5.5
CD56+_NKCells6.25
CD71+_EarlyErythroid4.5
CD8+_Tcells4.6
CardiacMyocytes6.55
Caudatenucleus6.15
Cerebellum4.4
CerebellumPeduncles6.65
CiliaryGanglion4
CingulateCortex5.85
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.1
FetalThyroid5.2
Fetalbrain5.45
Fetalliver4.65
Fetallung4.9
GlobusPallidus4.05
Heart7.05
Hypothalamus5.9
Kidney4.8
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-604.9
Leukemialymphoblastic(MOLT-4)4.35
Liver7.05
Lung5.95
Lymphnode4.7
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)15.35
MedullaOblongata5.05
OccipitalLobe4.9
OlfactoryBulb4.25
Ovary3.55
Pancreas4.3
PancreaticIslet5.7
ParietalLobe6.55
Pituitary6.3
Placenta5.45
Pons5.1
PrefrontalCortex6.65
Prostate6.25
Salivarygland4.4
SkeletalMuscle9.4
Skin4.3
SmoothMuscle6.05
Spinalcord5.9
SubthalamicNucleus5.15
SuperiorCervicalGanglion6.05
TemporalLobe5.05
Testis4.7
TestisGermCell6.5
TestisIntersitial4.65
TestisLeydigCell5.45
TestisSeminiferousTubule4.65
Thalamus5.6
Thymus4.2
Thyroid6.75
Tongue5.25
Tonsil5.25
Trachea4.75
TrigeminalGanglion5.25
Uterus4.4
UterusCorpus4.95
WholeBlood5.45
Wholebrain4.35
colon4.4
pineal_day6.6
pineal_night6.48
retina5.775
small_intestine4.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_67_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.97 ± 0.94
Basal Forebrain1.39 ± 0.17
Basal Part of Pons1.24 ± 0.38
Cerebellar Cortex1.36 ± 0.69
Cerebellar Nuclei1.96 ± 0.91
Claustrum2.35 ± 0.86
Epithalamus1.26 ± 0.76
Frontal Lobe1.36 ± 0.62
Globus Pallidus2.12 ± 0.36
Hypothalamus1.49 ± 0.63
Insula1.43 ± 0.66
Limbic Lobe1.49 ± 0.56
Mesencephalon1.64 ± 0.69
Myelencephalon1.54 ± 0.63
Occipital Lobe1.54 ± 0.61
Parietal Lobe1.48 ± 0.64
Pontine Tegmentum1.56 ± 0.68
Striatum1.73 ± 0.72
Subthalamus1.61 ± 0.61
Temporal Lobe1.43 ± 0.59
Thalamus1.47 ± 0.58
White Matter2.05 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mier2CBCerebellum21.87
31.78
Mier2CTXCerebral cortex91.8
75.63
Mier2HIPHippocampal region32.85
50.38
Mier2HPFHippocampal formation28.85
38.24
Mier2HYHypothalamus43.77
37.32
Mier2LSXLateral septal complex38.04
27.84
Mier2MBMidbrain19.3
19.13
Mier2MYMedulla35.21
40.85
Mier2OLFOlfactory bulb57.67
50.61
Mier2PPons18.33
21.03
Mier2PALPallidum35.89
32.99
Mier2RHPRetrohippocampal region18.81
16.3
Mier2sAMYStriatum-like amygdalar nuclei44.93
36.91
Mier2STRStriatum45.58
34.62
Mier2STRdStriatum dorsal region41.8
31.56
Mier2STRvStriatum ventral region60.27
43.87
Mier2THThalamus54.33
50.18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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