AutismKB 2.0

Annotation Detail for ROBO4


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Basic Information Top
Gene Symbol:ROBO4 ( ECSM4,FLJ20798,MGC133352,MGC133353,MRB )
Gene Full Name: roundabout homolog 4, magic roundabout (Drosophila)
Band: 11q24.2
Quick LinksEntrez ID:54538; OMIM: 607528; Uniprot ID:ROBO4_HUMAN; ENSEMBL ID: ENSG00000154133; HGNC ID: 17985
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus98 / 564012173
neonate125 / 310974019
infant0 / 236200 
juvenile0 / 555560 
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal439 / 3360307130
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow1 / 4880120
brain80 / 110098972
cervix0 / 481710 
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart8 / 8962689
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung18 / 33697453
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth2 / 6705229
muscle10 / 10771592
nerve0 / 157680 
ovary4 / 10205139
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta59 / 280825210
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen20 / 53952370
stomach1 / 9661910
testis9 / 33044227
thymus11 / 81131135
thyroid2 / 4747342
tonsil0 / 169990 
trachea12 / 52413228
umbilical cord189 / 1368013815
uterus17 / 23287872
vascular14 / 51780270
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220758_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.7
Adipocyte5.35
AdrenalCortex6.55
Adrenalgland4.85
Amygdala5.75
Appendix6.25
AtrioventricularNode4.7
BDCA4+_DentriticCells6
Bonemarrow5.85
BronchialEpithelialCells5.6
CD105+_Endothelial5.8
CD14+_Monocytes5.85
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid7.35
CD34+7.05
CD4+_Tcells5.95
CD56+_NKCells6.85
CD71+_EarlyErythroid5.45
CD8+_Tcells5.4
CardiacMyocytes7.75
Caudatenucleus5.55
Cerebellum4.65
CerebellumPeduncles6.6
CiliaryGanglion4.65
CingulateCortex7.15
Colorectaladenocarcinoma5.65
DorsalRootGanglion5.05
FetalThyroid5.55
Fetalbrain6.6
Fetalliver4.95
Fetallung4.6
GlobusPallidus5.6
Heart7.55
Hypothalamus6
Kidney4.8
Leukemia_chronicMyelogenousK-5625.2
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)5.35
Liver7.6
Lung6.05
Lymphnode4.7
Lymphoma_burkitts(Daudi)7.35
Lymphoma_burkitts(Raji)8.15
MedullaOblongata5.2
OccipitalLobe5.2
OlfactoryBulb4.6
Ovary5.15
Pancreas4.65
PancreaticIslet6.1
ParietalLobe6.2
Pituitary7
Placenta6
Pons8.75
PrefrontalCortex6.6
Prostate6.6
Salivarygland4.65
SkeletalMuscle7.4
Skin7.5
SmoothMuscle6.3
Spinalcord10.15
SubthalamicNucleus5.3
SuperiorCervicalGanglion8.35
TemporalLobe7.75
Testis4.8
TestisGermCell4.6
TestisIntersitial5
TestisLeydigCell6.05
TestisSeminiferousTubule4.95
Thalamus5.9
Thymus4.25
Thyroid7.1
Tongue7.6
Tonsil6.95
Trachea4.7
TrigeminalGanglion8.3
Uterus4.7
UterusCorpus5.2
WholeBlood6.05
Wholebrain4.7
colon5.8
pineal_day6.94
pineal_night7.2
retina6.95
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P104881
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.07 ± 0.48
Basal Forebrain4.01 ± 0.62
Basal Part of Pons4.22 ± 0.54
Cerebellar Cortex4.27 ± 0.57
Cerebellar Nuclei4.35 ± 0.54
Claustrum4.34 ± 0.7
Epithalamus3.96 ± 0.49
Frontal Lobe4.2 ± 0.54
Globus Pallidus4.83 ± 0.52
Hypothalamus3.53 ± 0.58
Insula4.22 ± 0.27
Limbic Lobe4.28 ± 0.62
Mesencephalon4.31 ± 0.51
Myelencephalon4.36 ± 0.59
Occipital Lobe4.65 ± 0.59
Parietal Lobe4.02 ± 0.59
Pontine Tegmentum4.15 ± 0.68
Striatum4.72 ± 0.67
Subthalamus3.91 ± 0.19
Temporal Lobe4.12 ± 0.58
Thalamus4.45 ± 0.66
White Matter4.75 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Robo4CBCerebellum49.21
78.92
Robo4CTXCerebral cortex17.4
11.52
Robo4HIPHippocampal region14.97
15.86
Robo4HPFHippocampal formation15.17
14.25
Robo4HYHypothalamus3.75
3
Robo4LSXLateral septal complex5.4
4.19
Robo4MBMidbrain6.09
5.2
Robo4MYMedulla20.39
19.61
Robo4OLFOlfactory bulb36.13
32.33
Robo4PPons10.88
10.07
Robo4PALPallidum11.88
9.8
Robo4RHPRetrohippocampal region14.94
11.63
Robo4sAMYStriatum-like amygdalar nuclei32.95
22.38
Robo4STRStriatum17.37
12.45
Robo4STRdStriatum dorsal region15.59
11.34
Robo4STRvStriatum ventral region19.54
13.37
Robo4THThalamus8.7
7.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00094818 19 223 241 VSIQEPQDYTEPVELLAVR Peptide Atlas
ROBO4_HUMAN_332 10 332 341 GPDSNVLLLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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