AutismKB 2.0

Annotation Detail for DDIT4


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Basic Information Top
Gene Symbol:DDIT4 ( Dig2,FLJ20500,REDD-1,REDD1,RP11-442H21.1,RTP801 )
Gene Full Name: DNA-damage-inducible transcript 4
Band: 10q22.1
Quick LinksEntrez ID:54541; OMIM: 607729; Uniprot ID:DDIT4_HUMAN; ENSEMBL ID: ENSG00000168209; HGNC ID: 24944
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor4 / 34366116
chondrosarcoma0 / 828230 
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal28 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites13 / 40015324
bladder1 / 2975733
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain10 / 11009899
cervix4 / 4817183
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine7 / 23447229
kidney4 / 21177718
larynx0 / 241450 
liver3 / 20774314
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland2 / 2015599
skin1 / 2105744
spleen0 / 539520 
stomach4 / 9661941
testis0 / 3304420 
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202887_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts2244.95
Adipocyte244.6
AdrenalCortex258.05
Adrenalgland377.75
Amygdala76.8
Appendix103.65
AtrioventricularNode309.8
BDCA4+_DentriticCells902.45
Bonemarrow246.45
BronchialEpithelialCells2085.95
CD105+_Endothelial25
CD14+_Monocytes85.95
CD19+_BCells(neg._sel.)103.65
CD33+_Myeloid27.75
CD34+48
CD4+_Tcells324.65
CD56+_NKCells1873.15
CD71+_EarlyErythroid5.35
CD8+_Tcells166.8
CardiacMyocytes555.9
Caudatenucleus27.7
Cerebellum131.15
CerebellumPeduncles58.1
CiliaryGanglion47.55
CingulateCortex28.3
Colorectaladenocarcinoma182.6
DorsalRootGanglion97.05
FetalThyroid22.7
Fetalbrain61.25
Fetalliver6.1
Fetallung349.75
GlobusPallidus15.05
Heart283.75
Hypothalamus101.1
Kidney75.5
Leukemia_chronicMyelogenousK-562576.55
Leukemia_promyelocytic-HL-60586.4
Leukemialymphoblastic(MOLT-4)249.3
Liver123.6
Lung3220.8
Lymphnode112.25
Lymphoma_burkitts(Daudi)38.45
Lymphoma_burkitts(Raji)2996.6
MedullaOblongata13.1
OccipitalLobe23.9
OlfactoryBulb763.85
Ovary1342.95
Pancreas1181
PancreaticIslet954.35
ParietalLobe23.7
Pituitary98.85
Placenta133.1
Pons11.25
PrefrontalCortex201.3
Prostate489.4
Salivarygland158.55
SkeletalMuscle127.55
Skin38.4
SmoothMuscle674.85
Spinalcord202.6
SubthalamicNucleus27.95
SuperiorCervicalGanglion60.15
TemporalLobe17.05
Testis45.55
TestisGermCell47
TestisIntersitial11.65
TestisLeydigCell27.7
TestisSeminiferousTubule50.4
Thalamus42.85
Thymus322.75
Thyroid133.5
Tongue317.8
Tonsil119.95
Trachea462.1
TrigeminalGanglion196.95
Uterus96.5
UterusCorpus27.5
WholeBlood50.8
Wholebrain162.25
colon155.25
pineal_day60.4
pineal_night37.08
retina230.775
small_intestine180.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P104318
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.05 ± 0.6
Basal Forebrain7.4 ± 0.38
Basal Part of Pons7.02 ± 0.48
Cerebellar Cortex7.39 ± 0.35
Cerebellar Nuclei6.97 ± 0.57
Claustrum6.31 ± 0.77
Epithalamus6.81 ± 0.76
Frontal Lobe7.01 ± 0.53
Globus Pallidus8.48 ± 0.39
Hypothalamus7.21 ± 0.44
Insula7.04 ± 0.31
Limbic Lobe6.88 ± 0.57
Mesencephalon7.18 ± 0.69
Myelencephalon7.16 ± 0.64
Occipital Lobe7.57 ± 0.4
Parietal Lobe7.18 ± 0.5
Pontine Tegmentum7.24 ± 0.49
Striatum7.49 ± 0.59
Subthalamus7.17 ± 0.34
Temporal Lobe7.14 ± 0.44
Thalamus7.58 ± 0.58
White Matter6.83 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ddit4CBCerebellum28.97
42.43
Ddit4CTXCerebral cortex59.56
45.11
Ddit4HIPHippocampal region43.21
62.06
Ddit4HPFHippocampal formation45.32
51.54
Ddit4HYHypothalamus12.31
9.25
Ddit4LSXLateral septal complex11.65
9.25
Ddit4MBMidbrain18.49
15.81
Ddit4MYMedulla46.6
47.03
Ddit4OLFOlfactory bulb60.98
50.18
Ddit4PPons22.37
22.78
Ddit4PALPallidum22.93
19.35
Ddit4RHPRetrohippocampal region49.78
38.93
Ddit4sAMYStriatum-like amygdalar nuclei38.77
27.51
Ddit4STRStriatum43.01
31.05
Ddit4STRdStriatum dorsal region47.68
35.21
Ddit4STRvStriatum ventral region40.22
26.56
Ddit4THThalamus24.27
20.3
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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