AutismKB 2.0

Annotation Detail for POU4F3


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Basic Information Top
Gene Symbol:POU4F3 ( BRN3C,DFNA15,MGC138412 )
Gene Full Name: POU class 4 homeobox 3
Band: 5q32
Quick LinksEntrez ID:5459; OMIM: 602460; Uniprot ID:PO4F3_HUMAN; ENSEMBL ID: ENSG00000091010; HGNC ID: 9220
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208554_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.55
Adipocyte5.05
AdrenalCortex5.65
Adrenalgland4.4
Amygdala5.35
Appendix5.5
AtrioventricularNode4.35
BDCA4+_DentriticCells5.65
Bonemarrow5.95
BronchialEpithelialCells5.15
CD105+_Endothelial5.3
CD14+_Monocytes5.6
CD19+_BCells(neg._sel.)5.6
CD33+_Myeloid6.55
CD34+6.55
CD4+_Tcells5.75
CD56+_NKCells6.25
CD71+_EarlyErythroid4.85
CD8+_Tcells4.95
CardiacMyocytes7.5
Caudatenucleus4.65
Cerebellum4.2
CerebellumPeduncles5.85
CiliaryGanglion3.9
CingulateCortex5.3
Colorectaladenocarcinoma5.2
DorsalRootGanglion4.1
FetalThyroid5.1
Fetalbrain5.2
Fetalliver4.5
Fetallung4.35
GlobusPallidus3.85
Heart7.95
Hypothalamus5.55
Kidney4.3
Leukemia_chronicMyelogenousK-5624.65
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.2
Liver7.15
Lung5.7
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.7
Lymphoma_burkitts(Raji)7.65
MedullaOblongata4.7
OccipitalLobe4.6
OlfactoryBulb4.1
Ovary4
Pancreas4.3
PancreaticIslet5.6
ParietalLobe5.55
Pituitary6.05
Placenta5.15
Pons4.95
PrefrontalCortex6.3
Prostate6.05
Salivarygland4.25
SkeletalMuscle7.25
Skin4.2
SmoothMuscle5.8
Spinalcord5.6
SubthalamicNucleus4.75
SuperiorCervicalGanglion6.35
TemporalLobe4.75
Testis4.45
TestisGermCell4.35
TestisIntersitial4.35
TestisLeydigCell5.15
TestisSeminiferousTubule4.4
Thalamus5.25
Thymus4
Thyroid6.35
Tongue5.2
Tonsil5.1
Trachea4.35
TrigeminalGanglion5.55
Uterus4.3
UterusCorpus5
WholeBlood5.75
Wholebrain4.25
colon5.2
pineal_day6.38
pineal_night6.24
retina6.3
small_intestine4.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14544_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.23 ± 0.93
Basal Forebrain1.71 ± 0.18
Basal Part of Pons1.47 ± 0.38
Cerebellar Cortex1.6 ± 0.83
Cerebellar Nuclei2.31 ± 1.18
Claustrum2.75 ± 0.96
Epithalamus1.4 ± 0.84
Frontal Lobe1.66 ± 0.69
Globus Pallidus2.43 ± 0.43
Hypothalamus1.7 ± 0.66
Insula1.7 ± 0.66
Limbic Lobe1.85 ± 0.69
Mesencephalon1.9 ± 0.71
Myelencephalon1.81 ± 0.66
Occipital Lobe1.77 ± 0.63
Parietal Lobe1.83 ± 0.78
Pontine Tegmentum1.9 ± 0.97
Striatum2.11 ± 0.92
Subthalamus2.09 ± 0.86
Temporal Lobe1.63 ± 0.59
Thalamus1.77 ± 0.7
White Matter2.27 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pou4f3CBCerebellum0.68
0.71
Pou4f3CTXCerebral cortex0.21
0.29
Pou4f3HIPHippocampal region0.26
1.62
Pou4f3HPFHippocampal formation0.28
1.09
Pou4f3HYHypothalamus0.08
0.11
Pou4f3LSXLateral septal complex0
0
Pou4f3MBMidbrain0.32
0.49
Pou4f3MYMedulla1.66
1.65
Pou4f3OLFOlfactory bulb0.31
0.77
Pou4f3PPons0.11
0.22
Pou4f3PALPallidum0.11
0.1
Pou4f3RHPRetrohippocampal region0.32
0.55
Pou4f3sAMYStriatum-like amygdalar nuclei0.07
0.08
Pou4f3STRStriatum0.08
0.17
Pou4f3STRdStriatum dorsal region0.1
0.22
Pou4f3STRvStriatum ventral region0.07
0.11
Pou4f3THThalamus0.86
0.99
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018