AutismKB 2.0

Annotation Detail for WDR74


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Basic Information Top
Gene Symbol:WDR74 ( FLJ10439,FLJ21730 )
Gene Full Name: WD repeat domain 74
Band: 11q12.3
Quick LinksEntrez ID:54663; OMIM: NA; Uniprot ID:WDR74_HUMAN; ENSEMBL ID: ENSG00000133316; HGNC ID: 25529
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus13 / 56401223
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult87 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor12 / 26384545
glioma8 / 10688374
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor15 / 103127145
lymphoma7 / 7175597
non-neoplasia3 / 9725030
normal134 / 336030739
ovarian tumor6 / 7668278
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer7 / 10268068
retinoblastoma3 / 4635664
skin tumor14 / 124949112
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood3 / 12347824
bone4 / 7165555
bone marrow1 / 4880120
brain33 / 110098929
cervix6 / 48171124
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye9 / 21105442
heart6 / 8962666
intestine17 / 23447272
kidney7 / 21177733
larynx0 / 241450 
liver17 / 20774381
lung23 / 33697468
lymph3 / 4427067
lymph node6 / 9161065
mammary gland7 / 15327145
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary7 / 10205168
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate11 / 18934558
salivary gland0 / 201550 
skin14 / 21057466
spleen3 / 5395255
stomach2 / 9661920
testis16 / 33044248
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221712_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.5
Adipocyte7.65
AdrenalCortex8.75
Adrenalgland6.5
Amygdala6.95
Appendix7.85
AtrioventricularNode7.35
BDCA4+_DentriticCells68.75
Bonemarrow7.45
BronchialEpithelialCells15.4
CD105+_Endothelial77.9
CD14+_Monocytes12.9
CD19+_BCells(neg._sel.)54.7
CD33+_Myeloid18.75
CD34+51.85
CD4+_Tcells58.3
CD56+_NKCells43.35
CD71+_EarlyErythroid8.4
CD8+_Tcells42.95
CardiacMyocytes10.55
Caudatenucleus6.35
Cerebellum6.8
CerebellumPeduncles10.15
CiliaryGanglion6.45
CingulateCortex8.05
Colorectaladenocarcinoma92.15
DorsalRootGanglion6.55
FetalThyroid7.55
Fetalbrain7.65
Fetalliver5.8
Fetallung6.3
GlobusPallidus5.65
Heart50.35
Hypothalamus10.1
Kidney6.3
Leukemia_chronicMyelogenousK-56231.25
Leukemia_promyelocytic-HL-6022.85
Leukemialymphoblastic(MOLT-4)26.35
Liver19.7
Lung38.45
Lymphnode6.35
Lymphoma_burkitts(Daudi)36.3
Lymphoma_burkitts(Raji)22.4
MedullaOblongata6.7
OccipitalLobe6.8
OlfactoryBulb5.45
Ovary5.25
Pancreas6.35
PancreaticIslet8.2
ParietalLobe7.9
Pituitary7.5
Placenta8.55
Pons7.45
PrefrontalCortex10.75
Prostate12.4
Salivarygland7.2
SkeletalMuscle9
Skin6.05
SmoothMuscle9.85
Spinalcord6.75
SubthalamicNucleus6.9
SuperiorCervicalGanglion9.2
TemporalLobe7.1
Testis7.15
TestisGermCell10.85
TestisIntersitial7.05
TestisLeydigCell7.05
TestisSeminiferousTubule10.75
Thalamus7.9
Thymus7.7
Thyroid10.35
Tongue7.75
Tonsil8.8
Trachea5.75
TrigeminalGanglion9.15
Uterus7.2
UterusCorpus6.85
WholeBlood9.4
Wholebrain14.55
colon5.8
pineal_day9.12
pineal_night8.22
retina8.125
small_intestine5.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P36157
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.66 ± 0.79
Basal Forebrain5.98 ± 0.49
Basal Part of Pons6.62 ± 0.64
Cerebellar Cortex6.45 ± 0.48
Cerebellar Nuclei6.05 ± 0.32
Claustrum5.56 ± 0.84
Epithalamus6.06 ± 0.59
Frontal Lobe6.37 ± 0.46
Globus Pallidus5.5 ± 0.35
Hypothalamus6.52 ± 0.37
Insula6.29 ± 0.35
Limbic Lobe6 ± 0.62
Mesencephalon5.95 ± 0.6
Myelencephalon6.09 ± 0.65
Occipital Lobe5.51 ± 0.64
Parietal Lobe6.14 ± 0.55
Pontine Tegmentum6.09 ± 0.42
Striatum5.57 ± 0.58
Subthalamus6.19 ± 0.38
Temporal Lobe6.34 ± 0.48
Thalamus6.04 ± 0.57
White Matter6.04 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr74CBCerebellum12.62
14.29
Wdr74CTXCerebral cortex45.98
35.33
Wdr74HIPHippocampal region39.94
48.87
Wdr74HPFHippocampal formation42.04
43.73
Wdr74HYHypothalamus27.1
23.04
Wdr74LSXLateral septal complex3.05
2.09
Wdr74MBMidbrain16.63
15.52
Wdr74MYMedulla16.04
20.27
Wdr74OLFOlfactory bulb45.98
37.75
Wdr74PPons21.42
24.97
Wdr74PALPallidum20.56
20.52
Wdr74RHPRetrohippocampal region46.85
37.59
Wdr74sAMYStriatum-like amygdalar nuclei19.11
14.37
Wdr74STRStriatum17.54
12.68
Wdr74STRdStriatum dorsal region14.4
10
Wdr74STRvStriatum ventral region29.78
21.4
Wdr74THThalamus22.49
18.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010248 18 274 291 GLQCHPSKPLLASCGLDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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