AutismKB 2.0

Annotation Detail for TMEM106B


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Basic Information Top
Gene Symbol:TMEM106B ( FLJ11273,MGC33727 )
Gene Full Name: transmembrane protein 106B
Band: 7p21.3
Quick LinksEntrez ID:54664; OMIM: 613413; Uniprot ID:T106B_HUMAN; ENSEMBL ID: ENSG00000106460; HGNC ID: 22407
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst3 / 6231948
fetus22 / 56401239
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult106 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor13 / 26384549
glioma3 / 10688328
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal186 / 336030755
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder6 / 29757201
blood3 / 12347824
bone3 / 7165541
bone marrow4 / 4880181
brain55 / 110098949
cervix0 / 481710 
connective tissue7 / 14925546
ear1 / 1621261
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye11 / 21105452
heart3 / 8962633
intestine10 / 23447242
kidney17 / 21177780
larynx0 / 241450 
liver7 / 20774333
lung11 / 33697432
lymph0 / 442700 
lymph node20 / 91610218
mammary gland9 / 15327158
mouth5 / 6705274
muscle8 / 10771574
nerve2 / 15768126
ovary4 / 10205139
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta24 / 28082585
prostate6 / 18934531
salivary gland1 / 2015549
skin8 / 21057437
spleen0 / 539520 
stomach6 / 9661962
testis19 / 33044257
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218930_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.85
Adipocyte9
AdrenalCortex18.8
Adrenalgland40.5
Amygdala62.95
Appendix10.05
AtrioventricularNode7.25
BDCA4+_DentriticCells19.2
Bonemarrow8.55
BronchialEpithelialCells42.95
CD105+_Endothelial20.45
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)24.95
CD33+_Myeloid13.35
CD34+53.4
CD4+_Tcells83.3
CD56+_NKCells85.75
CD71+_EarlyErythroid7.75
CD8+_Tcells52.9
CardiacMyocytes12.45
Caudatenucleus7.05
Cerebellum7.2
CerebellumPeduncles10.25
CiliaryGanglion6.75
CingulateCortex8.6
Colorectaladenocarcinoma23.65
DorsalRootGanglion6.9
FetalThyroid8.55
Fetalbrain9.65
Fetalliver17.6
Fetallung7.75
GlobusPallidus6.3
Heart12.05
Hypothalamus11.05
Kidney7.05
Leukemia_chronicMyelogenousK-5628.35
Leukemia_promyelocytic-HL-606.75
Leukemialymphoblastic(MOLT-4)5.75
Liver11.65
Lung8.5
Lymphnode7.2
Lymphoma_burkitts(Daudi)10.25
Lymphoma_burkitts(Raji)12
MedullaOblongata7.75
OccipitalLobe19.05
OlfactoryBulb6.9
Ovary5.7
Pancreas7.05
PancreaticIslet18.95
ParietalLobe8.95
Pituitary63.65
Placenta74
Pons8.25
PrefrontalCortex65.9
Prostate73.65
Salivarygland7
SkeletalMuscle10.9
Skin6.85
SmoothMuscle9.55
Spinalcord8.4
SubthalamicNucleus8.1
SuperiorCervicalGanglion10.7
TemporalLobe7.5
Testis6.75
TestisGermCell9.7
TestisIntersitial7.2
TestisLeydigCell8.2
TestisSeminiferousTubule6.8
Thalamus8.3
Thymus7.9
Thyroid50.65
Tongue9.55
Tonsil8
Trachea34.35
TrigeminalGanglion9.15
Uterus108.75
UterusCorpus8.65
WholeBlood19.55
Wholebrain26.5
colon117.6
pineal_day109.9
pineal_night100.2
retina14.15
small_intestine77.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P8522
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.58 ± 0.22
Basal Forebrain9.35 ± 0.2
Basal Part of Pons9.34 ± 0.26
Cerebellar Cortex9.51 ± 0.28
Cerebellar Nuclei9.37 ± 0.27
Claustrum9.49 ± 0.3
Epithalamus9.69 ± 0.26
Frontal Lobe9.49 ± 0.26
Globus Pallidus9.86 ± 0.21
Hypothalamus9.63 ± 0.3
Insula9.5 ± 0.28
Limbic Lobe9.65 ± 0.26
Mesencephalon9.64 ± 0.25
Myelencephalon9.55 ± 0.27
Occipital Lobe9.85 ± 0.22
Parietal Lobe9.58 ± 0.22
Pontine Tegmentum9.58 ± 0.24
Striatum9.4 ± 0.22
Subthalamus9.53 ± 0.19
Temporal Lobe9.5 ± 0.22
Thalamus9.65 ± 0.25
White Matter10.37 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem106bCBCerebellum56.5
100
Tmem106bCTXCerebral cortex100
100
Tmem106bHIPHippocampal region100
100
Tmem106bHPFHippocampal formation100
100
Tmem106bHYHypothalamus83.22
81.99
Tmem106bLSXLateral septal complex98.96
98.35
Tmem106bMBMidbrain96.12
99.02
Tmem106bMYMedulla73.87
87.82
Tmem106bOLFOlfactory bulb100
100
Tmem106bPPons76.8
88.7
Tmem106bPALPallidum87.32
97.42
Tmem106bRHPRetrohippocampal region100
100
Tmem106bsAMYStriatum-like amygdalar nuclei100
100
Tmem106bSTRStriatum100
100
Tmem106bSTRdStriatum dorsal region100
100
Tmem106bSTRvStriatum ventral region100
100
Tmem106bTHThalamus91.46
96
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039955 13 57 69 DSVTCPTCQGTGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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