AutismKB 2.0

Annotation Detail for LRRN3


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Basic Information Top
Gene Symbol:LRRN3 ( FIGLER5,FLJ11129,NLRR-3,NLRR3 )
Gene Full Name: leucine rich repeat neuronal 3
Band: 7q31.1
Quick LinksEntrez ID:54674; OMIM: NA; Uniprot ID:LRRN3_HUMAN; ENSEMBL ID: ENSG00000173114; HGNC ID: 17200
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus85 / 564012150
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor13 / 26384549
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal176 / 336030752
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain122 / 1100989110
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye3 / 21105414
heart5 / 8962655
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver1 / 2077434
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta7 / 28082524
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis39 / 330442118
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209840_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.45
Adipocyte7.2
AdrenalCortex14.65
Adrenalgland7.4
Amygdala37.35
Appendix8.75
AtrioventricularNode5.5
BDCA4+_DentriticCells7
Bonemarrow6.95
BronchialEpithelialCells6.55
CD105+_Endothelial6.8
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)7.15
CD33+_Myeloid8.4
CD34+8.6
CD4+_Tcells81.1
CD56+_NKCells8
CD71+_EarlyErythroid6.45
CD8+_Tcells213
CardiacMyocytes9.05
Caudatenucleus21.8
Cerebellum6.45
CerebellumPeduncles8.8
CiliaryGanglion5.05
CingulateCortex62.2
Colorectaladenocarcinoma6.8
DorsalRootGanglion5.5
FetalThyroid7.1
Fetalbrain129.2
Fetalliver6.1
Fetallung5.65
GlobusPallidus15.15
Heart9
Hypothalamus13.75
Kidney5.8
Leukemia_chronicMyelogenousK-5626.25
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.5
Liver9.35
Lung7.5
Lymphnode6.5
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)9.7
MedullaOblongata23.95
OccipitalLobe27.85
OlfactoryBulb5.45
Ovary4.65
Pancreas5.55
PancreaticIslet7.35
ParietalLobe25.85
Pituitary10.25
Placenta6.8
Pons23.55
PrefrontalCortex45.35
Prostate7.95
Salivarygland6.85
SkeletalMuscle9.55
Skin6.8
SmoothMuscle7.95
Spinalcord8.9
SubthalamicNucleus17.35
SuperiorCervicalGanglion17.15
TemporalLobe14.95
Testis5.9
TestisGermCell63.3
TestisIntersitial6.85
TestisLeydigCell7.55
TestisSeminiferousTubule9.5
Thalamus13.05
Thymus5.4
Thyroid9.25
Tongue7.2
Tonsil6.7
Trachea5.75
TrigeminalGanglion9
Uterus5.6
UterusCorpus6.3
WholeBlood7.55
Wholebrain12
colon6.85
pineal_day8.64
pineal_night8.46
retina8.5
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_443_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.98 ± 0.2
Basal Forebrain9.23 ± 0.31
Basal Part of Pons8.49 ± 0.34
Cerebellar Cortex8.76 ± 0.22
Cerebellar Nuclei7.88 ± 0.37
Claustrum8.78 ± 0.42
Epithalamus8.93 ± 0.36
Frontal Lobe8.98 ± 0.34
Globus Pallidus8.16 ± 0.25
Hypothalamus9.26 ± 0.51
Insula9.06 ± 0.24
Limbic Lobe8.77 ± 0.4
Mesencephalon9.04 ± 0.43
Myelencephalon8.83 ± 0.47
Occipital Lobe9.14 ± 0.43
Parietal Lobe8.96 ± 0.47
Pontine Tegmentum8.92 ± 0.42
Striatum8.6 ± 0.57
Subthalamus8.61 ± 0.35
Temporal Lobe8.92 ± 0.35
Thalamus8.84 ± 0.44
White Matter6.89 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrrn3CBCerebellum30.78
68.18
Lrrn3CTXCerebral cortex87.32
57.76
Lrrn3HIPHippocampal region73.39
100
Lrrn3HPFHippocampal formation91.52
100
Lrrn3HYHypothalamus47.96
29.95
Lrrn3LSXLateral septal complex85.3
80.69
Lrrn3MBMidbrain47.04
35.03
Lrrn3MYMedulla36.23
30.58
Lrrn3OLFOlfactory bulb86.97
85.96
Lrrn3PPons44.22
36.18
Lrrn3PALPallidum54.33
40.31
Lrrn3RHPRetrohippocampal region97.7
100
Lrrn3sAMYStriatum-like amygdalar nuclei66.85
45.49
Lrrn3STRStriatum62.84
42.15
Lrrn3STRdStriatum dorsal region37.35
23.5
Lrrn3STRvStriatum ventral region99.71
84.51
Lrrn3THThalamus42.71
35.52
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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