AutismKB 2.0

Annotation Detail for CTSA


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Basic Information Top
Gene Symbol:CTSA ( GLB2,GSL,NGBE,PPCA,PPGB )
Gene Full Name: cathepsin A
Band: 20q13.12
Quick LinksEntrez ID:5476; OMIM: 613111; Uniprot ID:PPGB_HUMAN; ENSEMBL ID: ENSG00000064601; HGNC ID: 9251
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst8 / 62319128
fetus81 / 564012143
neonate12 / 31097385
infant2 / 2362084
juvenile14 / 55556251
adult497 / 1939121256
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma3 / 17475171
breast (mammary gland) tumor34 / 94178361
cervical tumor12 / 34366349
chondrosarcoma21 / 82823253
colorectal tumor48 / 114246420
esophageal tumor7 / 17290404
gastrointestinal tumor67 / 119369561
germ cell tumor33 / 263845125
glioma39 / 106883364
head and neck tumor19 / 136302139
kidney tumor8 / 68959116
leukemia18 / 95842187
liver tumor22 / 96359228
lung tumor24 / 103127232
lymphoma5 / 7175569
non-neoplasia34 / 97250349
normal915 / 3360307272
ovarian tumor19 / 76682247
pancreatic tumor36 / 104616344
primitive neuroectodermal tumor of the CNS41 / 125680326
prostate cancer15 / 102680146
retinoblastoma0 / 463560 
skin tumor72 / 124949576
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor35 / 90257387
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland42 / 331971265
ascites14 / 40015349
bladder14 / 29757470
blood38 / 123478307
bone20 / 71655279
bone marrow6 / 48801122
brain241 / 1100989218
cervix15 / 48171311
connective tissue47 / 149255314
ear0 / 162120 
embryonic tissue21 / 21572297
esophagus7 / 20209346
eye17 / 21105480
heart24 / 89626267
intestine122 / 234472520
kidney65 / 211777306
larynx4 / 24145165
liver43 / 207743206
lung71 / 336974210
lymph0 / 442700 
lymph node20 / 91610218
mammary gland60 / 153271391
mouth5 / 6705274
muscle11 / 107715102
nerve2 / 15768126
ovary25 / 102051244
pancreas50 / 214812232
parathyroid4 / 20539194
pharynx3 / 4132872
pituitary gland3 / 16585180
placenta109 / 280825388
prostate21 / 189345110
salivary gland1 / 2015549
skin148 / 210574702
spleen12 / 53952222
stomach46 / 96619476
testis56 / 330442169
thymus18 / 81131221
thyroid11 / 47473231
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord1 / 1368073
uterus61 / 232878261
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200661_at
Cell line Expression level Expression bar
721_B_lymphoblasts199.1
Adipocyte576.1
AdrenalCortex753.35
Adrenalgland1580.2
Amygdala135.2
Appendix32.65
AtrioventricularNode21.9
BDCA4+_DentriticCells422.5
Bonemarrow305.8
BronchialEpithelialCells50.1
CD105+_Endothelial111.7
CD14+_Monocytes1878.05
CD19+_BCells(neg._sel.)150.85
CD33+_Myeloid2909.7
CD34+372.75
CD4+_Tcells373.4
CD56+_NKCells274.9
CD71+_EarlyErythroid47.05
CD8+_Tcells495.7
CardiacMyocytes483.25
Caudatenucleus100.75
Cerebellum115.8
CerebellumPeduncles98.95
CiliaryGanglion23.4
CingulateCortex104.15
Colorectaladenocarcinoma379.1
DorsalRootGanglion55.1
FetalThyroid167.4
Fetalbrain87.55
Fetalliver159.75
Fetallung289.8
GlobusPallidus35.5
Heart426.25
Hypothalamus238.4
Kidney1268.3
Leukemia_chronicMyelogenousK-56243.8
Leukemia_promyelocytic-HL-6039
Leukemialymphoblastic(MOLT-4)39.4
Liver472.55
Lung838.9
Lymphnode387.35
Lymphoma_burkitts(Daudi)35.8
Lymphoma_burkitts(Raji)67.45
MedullaOblongata69.55
OccipitalLobe111
OlfactoryBulb191.55
Ovary60.35
Pancreas183.9
PancreaticIslet530.3
ParietalLobe84.65
Pituitary150.55
Placenta888.75
Pons27.55
PrefrontalCortex213.85
Prostate242.4
Salivarygland46.1
SkeletalMuscle33.3
Skin24.85
SmoothMuscle938.75
Spinalcord135.3
SubthalamicNucleus49.8
SuperiorCervicalGanglion21.15
TemporalLobe69.4
Testis165
TestisGermCell122.05
TestisIntersitial38.6
TestisLeydigCell47.6
TestisSeminiferousTubule68.2
Thalamus158.7
Thymus191.6
Thyroid360
Tongue158.35
Tonsil150
Trachea100.9
TrigeminalGanglion28.75
Uterus180.3
UterusCorpus193.05
WholeBlood947.4
Wholebrain273.85
colon497.05
pineal_day1446.94
pineal_night2294.62
retina594.65
small_intestine170.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P74374
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.78 ± 0.48
Basal Forebrain5.7 ± 0.34
Basal Part of Pons6.31 ± 0.39
Cerebellar Cortex6.23 ± 0.51
Cerebellar Nuclei6.17 ± 0.29
Claustrum5.66 ± 0.62
Epithalamus6.33 ± 0.65
Frontal Lobe6.3 ± 0.44
Globus Pallidus5.64 ± 0.35
Hypothalamus6.13 ± 0.49
Insula6.34 ± 0.34
Limbic Lobe5.83 ± 0.52
Mesencephalon5.89 ± 0.55
Myelencephalon6.07 ± 0.47
Occipital Lobe5.71 ± 0.48
Parietal Lobe6.08 ± 0.5
Pontine Tegmentum6.04 ± 0.45
Striatum5.59 ± 0.42
Subthalamus5.91 ± 0.27
Temporal Lobe6.17 ± 0.42
Thalamus6.26 ± 0.37
White Matter5.37 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PpgbCBCerebellum45.14
100
PpgbCTXCerebral cortex100
100
PpgbHIPHippocampal region100
100
PpgbHPFHippocampal formation100
100
PpgbHYHypothalamus100
100
PpgbLSXLateral septal complex100
100
PpgbMBMidbrain100
100
PpgbMYMedulla51.97
92.07
PpgbOLFOlfactory bulb100
100
PpgbPPons64.21
98.83
PpgbPALPallidum100
100
PpgbRHPRetrohippocampal region100
100
PpgbsAMYStriatum-like amygdalar nuclei100
100
PpgbSTRStriatum100
100
PpgbSTRdStriatum dorsal region100
100
PpgbSTRvStriatum ventral region100
100
PpgbTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001226 7 246 252 CNFYDNK Peptide Atlas
PPGB_HUMAN_0 0 0 0 DLECVTNLQEVAR PRIDE
PPGB_HUMAN_0 0 0 0 YGDSGEQIAGFVK PRIDE
PPGB_HUMAN_245 20 245 264 CNFYDNKDLECVTNLQEVAR PRIDE
PPGB_HUMAN_252 13 252 264 DLECVTNLQEVAR PRIDE
PPGB_HUMAN_29 9 29 37 APDQDEIQR PRIDE
PPGB_HUMAN_348 23 348 370 ALNIPEQLPQWDMCNFLVNLQYR PRIDE
PPGB_HUMAN_375 8 375 382 SMNSQYLK PRIDE
PPGB_HUMAN_429 13 429 441 YGDSGEQIAGFVK PRIDE
PPGB_HUMAN_442 11 442 452 EFSHIAFLTIK PRIDE
PPGB_HUMAN_453 20 453 472 GAGHMVPTDKPLAAFTMFSR PRIDE
PPGB_HUMAN_454 20 454 473 GAGHMVPTDKPLAAFTMFSR PRIDE
PPGB_HUMAN_473 7 473 479 FLNKQPY PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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