AutismKB 2.0

Annotation Detail for PPIB


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Basic Information Top
Gene Symbol:PPIB ( CYP-S1,CYPB,MGC14109,MGC2224,OI9,SCYLP )
Gene Full Name: peptidylprolyl isomerase B (cyclophilin B)
Band: 15q22.31
Quick LinksEntrez ID:5479; OMIM: 123841; Uniprot ID:PPIB_HUMAN; ENSEMBL ID: ENSG00000166794; HGNC ID: 9255
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body30 / 70761423
blastocyst14 / 62319224
fetus42 / 56401274
neonate3 / 3109796
infant2 / 2362084
juvenile5 / 5555689
adult379 / 1939121195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor12 / 12794937
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor5 / 34366145
chondrosarcoma18 / 82823217
colorectal tumor22 / 114246192
esophageal tumor2 / 17290115
gastrointestinal tumor32 / 119369268
germ cell tumor20 / 26384575
glioma10 / 10688393
head and neck tumor24 / 136302176
kidney tumor17 / 68959246
leukemia14 / 95842146
liver tumor28 / 96359290
lung tumor24 / 103127232
lymphoma5 / 7175569
non-neoplasia5 / 9725051
normal497 / 3360307147
ovarian tumor12 / 76682156
pancreatic tumor27 / 104616258
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer21 / 102680204
retinoblastoma9 / 46356194
skin tumor39 / 124949312
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor34 / 90257376
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland19 / 33197572
ascites10 / 40015249
bladder71 / 297572385
blood18 / 123478145
bone22 / 71655307
bone marrow9 / 48801184
brain54 / 110098949
cervix5 / 48171103
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue55 / 215722254
esophagus2 / 2020998
eye33 / 211054156
heart8 / 8962689
intestine46 / 234472196
kidney25 / 211777118
larynx8 / 24145331
liver42 / 207743202
lung70 / 336974207
lymph2 / 4427045
lymph node3 / 9161032
mammary gland20 / 153271130
mouth4 / 6705259
muscle9 / 10771583
nerve1 / 1576863
ovary15 / 102051146
pancreas56 / 214812260
parathyroid2 / 2053997
pharynx15 / 41328362
pituitary gland5 / 16585301
placenta43 / 280825153
prostate35 / 189345184
salivary gland3 / 20155148
skin57 / 210574270
spleen4 / 5395274
stomach67 / 96619693
testis11 / 33044233
thymus0 / 811310 
thyroid17 / 47473358
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord3 / 13680219
uterus54 / 232878231
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200968_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts2028.05
Adipocyte910.9
AdrenalCortex172.1
Adrenalgland464.85
Amygdala104.75
Appendix15.4
AtrioventricularNode23.4
BDCA4+_DentriticCells3389.15
Bonemarrow159.2
BronchialEpithelialCells2127.25
CD105+_Endothelial362.35
CD14+_Monocytes914.25
CD19+_BCells(neg._sel.)1014.25
CD33+_Myeloid865.5
CD34+1490.6
CD4+_Tcells841.9
CD56+_NKCells1206.75
CD71+_EarlyErythroid34.8
CD8+_Tcells692.1
CardiacMyocytes1444.9
Caudatenucleus119.7
Cerebellum69.45
CerebellumPeduncles143
CiliaryGanglion20.4
CingulateCortex99.65
Colorectaladenocarcinoma709.7
DorsalRootGanglion63.4
FetalThyroid1348.75
Fetalbrain197.25
Fetalliver314.5
Fetallung919.7
GlobusPallidus16.9
Heart559.6
Hypothalamus303.7
Kidney235.65
Leukemia_chronicMyelogenousK-562549.85
Leukemia_promyelocytic-HL-60414.75
Leukemialymphoblastic(MOLT-4)238
Liver3012.3
Lung1375.95
Lymphnode419.3
Lymphoma_burkitts(Daudi)959.1
Lymphoma_burkitts(Raji)310.3
MedullaOblongata79
OccipitalLobe73.8
OlfactoryBulb394.45
Ovary362.6
Pancreas658
PancreaticIslet918.3
ParietalLobe54.7
Pituitary548.05
Placenta1314.35
Pons46.6
PrefrontalCortex141.35
Prostate1881.45
Salivarygland172.95
SkeletalMuscle8
Skin11.65
SmoothMuscle2544.35
Spinalcord262.75
SubthalamicNucleus54.4
SuperiorCervicalGanglion12.75
TemporalLobe101.3
Testis135.4
TestisGermCell312.95
TestisIntersitial94.55
TestisLeydigCell105.9
TestisSeminiferousTubule62.8
Thalamus201
Thymus568.05
Thyroid1436.1
Tongue98.1
Tonsil392.25
Trachea341.55
TrigeminalGanglion10.8
Uterus1336.35
UterusCorpus422.8
WholeBlood528.8
Wholebrain455.45
colon687.6
pineal_day296.92
pineal_night281.44
retina419.1
small_intestine1098.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11322_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.29 ± 0.33
Basal Forebrain8.2 ± 0.2
Basal Part of Pons8.13 ± 0.24
Cerebellar Cortex8.17 ± 0.18
Cerebellar Nuclei8.31 ± 0.27
Claustrum7.94 ± 0.34
Epithalamus8.45 ± 0.22
Frontal Lobe8.33 ± 0.26
Globus Pallidus8.78 ± 0.15
Hypothalamus8.41 ± 0.32
Insula8.31 ± 0.21
Limbic Lobe8.28 ± 0.33
Mesencephalon8.24 ± 0.3
Myelencephalon8.28 ± 0.26
Occipital Lobe8.04 ± 0.18
Parietal Lobe8.13 ± 0.22
Pontine Tegmentum8.28 ± 0.22
Striatum8.2 ± 0.25
Subthalamus8.17 ± 0.15
Temporal Lobe8.23 ± 0.24
Thalamus8.27 ± 0.21
White Matter9.11 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PpibCBCerebellum41.33
100
PpibCTXCerebral cortex100
100
PpibHIPHippocampal region100
100
PpibHPFHippocampal formation100
100
PpibHYHypothalamus82.61
86.83
PpibLSXLateral septal complex100
100
PpibMBMidbrain100
100
PpibMYMedulla100
100
PpibOLFOlfactory bulb100
100
PpibPPons93.66
100
PpibPALPallidum89.18
100
PpibRHPRetrohippocampal region100
100
PpibsAMYStriatum-like amygdalar nuclei100
100
PpibSTRStriatum90.83
85.36
PpibSTRdStriatum dorsal region83.94
78.82
PpibSTRvStriatum ventral region99.67
88.41
PpibTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001017 15 202 216 CGKIEVEKPFAIAKE Peptide Atlas
PPIB_HUMAN_0 0 0 0 DKPLKDVIIADCGK PRIDE
PPIB_HUMAN_0 0 0 0 TVDNFVALATGEK PRIDE
PPIB_HUMAN_108 13 108 120 SIYGERFPDENFK PRIDE
PPIB_HUMAN_108 15 108 122 SIYGERFPDENFKLK PRIDE
PPIB_HUMAN_121 16 121 136 LKHYGPGWVSMANAGK PRIDE
PPIB_HUMAN_123 14 123 136 HYGPGWVSMANAGK PRIDE
PPIB_HUMAN_124 14 124 137 HYGPGWVSMANAGK PRIDE
PPIB_HUMAN_137 13 137 149 DTNGSQFFITTVK PRIDE
PPIB_HUMAN_138 13 138 150 DTNGSQFFITTVK PRIDE
PPIB_HUMAN_150 13 150 162 TAWLDGKHVVFGK PRIDE
PPIB_HUMAN_157 15 157 171 HVVFGKVLEGMEVVR PRIDE
PPIB_HUMAN_163 10 163 172 VLEGMEVVRK PRIDE
PPIB_HUMAN_163 9 163 171 VLEGMEVVR PRIDE
PPIB_HUMAN_164 9 164 172 VLEGMEVVR PRIDE
PPIB_HUMAN_174 9 174 182 VESTKTDSR PRIDE
PPIB_HUMAN_182 14 182 195 DKPLKDVIIADCGK PRIDE
PPIB_HUMAN_182 25 182 206 DKPLKDVIIADCGKIEVEKPFAIAK PRIDE
PPIB_HUMAN_183 14 183 196 DKPLKDVIIADCGK PRIDE
PPIB_HUMAN_187 21 187 207 DVIIADCGKIEVEKPFAIAKE PRIDE
PPIB_HUMAN_196 12 196 207 IEVEKPFAIAKE PRIDE
PPIB_HUMAN_197 11 197 207 IEVEKPFAIAK PRIDE
PPIB_HUMAN_197 12 197 208 IEVEKPFAIAKE PRIDE
PPIB_HUMAN_43 16 43 58 IGDEDVGRVIFGLFGK PRIDE
PPIB_HUMAN_43 20 43 62 IGDEDVGRVIFGLFGKTVPK PRIDE
PPIB_HUMAN_43 8 43 50 IGDEDVGR PRIDE
PPIB_HUMAN_51 8 51 58 VIFGLFGK PRIDE
PPIB_HUMAN_52 8 52 59 VIFGLFGK PRIDE
PPIB_HUMAN_63 13 63 75 TVDNFVALATGEK PRIDE
PPIB_HUMAN_63 18 63 80 TVDNFVALATGEKGFGYK PRIDE
PPIB_HUMAN_63 21 63 83 TVDNFVALATGEKGFGYKNSK PRIDE
PPIB_HUMAN_64 13 64 76 TVDNFVALATGEK PRIDE
PPIB_HUMAN_87 14 87 100 VIKDFMIQGGDFTR PRIDE
PPIB_HUMAN_87 21 87 107 VIKDFMIQGGDFTRGDGTGGK PRIDE
PPIB_HUMAN_88 14 88 101 VIKDFMIQGGDFTR PRIDE
PPIB_HUMAN_90 11 90 100 DFMIQGGDFTR PRIDE
PPIB_HUMAN_90 18 90 107 DFMIQGGDFTRGDGTGGK PRIDE
PPIB_HUMAN_91 11 91 101 DFMIQGGDFTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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