AutismKB 2.0

Annotation Detail for KLHL24


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Basic Information Top
Gene Symbol:KLHL24 ( DRE1,FLJ25796,KRIP6 )
Gene Full Name: kelch-like 24 (Drosophila)
Band: 3q27.1
Quick LinksEntrez ID:54800; OMIM: 611295; Uniprot ID:KLH24_HUMAN; ENSEMBL ID: ENSG00000114796; HGNC ID: 25947
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus18 / 56401231
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult99 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor9 / 26384534
glioma1 / 1068839
head and neck tumor21 / 136302154
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal144 / 336030742
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor47 / 124949376
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood3 / 12347824
bone1 / 7165513
bone marrow5 / 48801102
brain35 / 110098931
cervix2 / 4817141
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye2 / 2110549
heart2 / 8962622
intestine10 / 23447242
kidney11 / 21177751
larynx0 / 241450 
liver7 / 20774333
lung24 / 33697471
lymph0 / 442700 
lymph node9 / 9161098
mammary gland20 / 153271130
mouth10 / 67052149
muscle5 / 10771546
nerve0 / 157680 
ovary3 / 10205129
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate6 / 18934531
salivary gland0 / 201550 
skin50 / 210574237
spleen3 / 5395255
stomach4 / 9661941
testis11 / 33044233
thymus3 / 8113136
thyroid11 / 47473231
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221986_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.25
Adipocyte8.9
AdrenalCortex13.6
Adrenalgland8.55
Amygdala8.65
Appendix12.35
AtrioventricularNode12.8
BDCA4+_DentriticCells20.85
Bonemarrow11.1
BronchialEpithelialCells8.35
CD105+_Endothelial8.6
CD14+_Monocytes14.35
CD19+_BCells(neg._sel.)76.45
CD33+_Myeloid12.65
CD34+10.35
CD4+_Tcells10.75
CD56+_NKCells21.25
CD71+_EarlyErythroid9.15
CD8+_Tcells21.9
CardiacMyocytes20.6
Caudatenucleus7.95
Cerebellum7.4
CerebellumPeduncles11.85
CiliaryGanglion10
CingulateCortex10.15
Colorectaladenocarcinoma8.95
DorsalRootGanglion9.75
FetalThyroid9.7
Fetalbrain8.6
Fetalliver8.3
Fetallung7.9
GlobusPallidus7.85
Heart18.25
Hypothalamus8.9
Kidney8.9
Leukemia_chronicMyelogenousK-5628.25
Leukemia_promyelocytic-HL-608.2
Leukemialymphoblastic(MOLT-4)7.15
Liver15.85
Lung10.2
Lymphnode7.1
Lymphoma_burkitts(Daudi)12.35
Lymphoma_burkitts(Raji)15.65
MedullaOblongata7.9
OccipitalLobe7.95
OlfactoryBulb7
Ovary7.45
Pancreas8.15
PancreaticIslet10
ParietalLobe11.2
Pituitary10.75
Placenta8.85
Pons9.55
PrefrontalCortex10.2
Prostate9.9
Salivarygland8
SkeletalMuscle20.4
Skin10.9
SmoothMuscle10
Spinalcord9.3
SubthalamicNucleus9.1
SuperiorCervicalGanglion17.5
TemporalLobe8.8
Testis7.65
TestisGermCell6.9
TestisIntersitial8.95
TestisLeydigCell10.05
TestisSeminiferousTubule7.95
Thalamus9.8
Thymus7.7
Thyroid10.25
Tongue12.4
Tonsil9.5
Trachea7.75
TrigeminalGanglion13.8
Uterus7.2
UterusCorpus23.15
WholeBlood15.35
Wholebrain7.85
colon13.05
pineal_day10.7
pineal_night10.6
retina10.6
small_intestine9.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P521994
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.09 ± 0.35
Basal Forebrain7.6 ± 0.11
Basal Part of Pons7.23 ± 0.28
Cerebellar Cortex7.69 ± 0.22
Cerebellar Nuclei7.54 ± 0.28
Claustrum7.2 ± 0.39
Epithalamus7.58 ± 0.33
Frontal Lobe7.42 ± 0.33
Globus Pallidus7.91 ± 0.39
Hypothalamus7.67 ± 0.28
Insula7.33 ± 0.21
Limbic Lobe7.17 ± 0.33
Mesencephalon7.58 ± 0.33
Myelencephalon7.48 ± 0.35
Occipital Lobe7.83 ± 0.27
Parietal Lobe7.52 ± 0.37
Pontine Tegmentum7.52 ± 0.34
Striatum7.4 ± 0.38
Subthalamus7.62 ± 0.41
Temporal Lobe7.27 ± 0.29
Thalamus7.67 ± 0.27
White Matter8.45 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl24CBCerebellum7.72
5.68
Klhl24CTXCerebral cortex8.89
5.45
Klhl24HIPHippocampal region37.1
16.42
Klhl24HPFHippocampal formation28.09
15.41
Klhl24HYHypothalamus4.52
2.9
Klhl24LSXLateral septal complex1.58
0.79
Klhl24MBMidbrain3.99
3
Klhl24MYMedulla8.02
5.83
Klhl24OLFOlfactory bulb18.23
11
Klhl24PPons6.99
4.4
Klhl24PALPallidum2.29
1.49
Klhl24RHPRetrohippocampal region16.69
13.63
Klhl24sAMYStriatum-like amygdalar nuclei4.14
2.93
Klhl24STRStriatum2.34
1.37
Klhl24STRdStriatum dorsal region1.13
0.66
Klhl24STRvStriatum ventral region6.25
3.17
Klhl24THThalamus6.56
3.8
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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